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Pharmacology II > Blood Drugs to Know and MOA > Flashcards

Blood Drugs to Know and MOA Flashcards

1
Q

protamine

A

tx of bleeding

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2
Q

Abciximab

A

Platelet Inhibitors

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3
Q

dalteparin

A

low molecular weight heparins ( anticoagulant)

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4
Q

these are all competitive , reversible inhibitors of thrombin

A

thrombin inhibitors

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5
Q

this platelet aggregration inh drug is a chimeric monoclonal Ab; binds to GP receptor and blocks binding of fibrinogen; very expensive ; adverse effect of bleeding

A

abciximab

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6
Q

warfarin ( Coumadin)

A

other anticoagulants

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7
Q

this thrombin inhibitor drug binds to antithrombin III ; leads to rapid inactivation of thrombin and factor Xa; Low molecular weights/antithrombin III complex only inactivates factor Xa

A

thrombin inhibitors - heparin

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8
Q

this anti bleeding med inhibits plasminogen activation

A

aminocaproic acid

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9
Q

rivaroxaban

A

anticoagulant ( Factor Xa inhibitor)

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10
Q

dabigatran ( pradaxa)

A

anticoagulant ( direct thrombin inhibitor)

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11
Q

this platelet aggre. inh inhibits phosphodiesterase III ; prevents degradation of cAMP; adverse effects of HA and GI effects ; CI in pts with CHF

A

cilostazol

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12
Q

reteplase

A

thrombolytic agents

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13
Q

darbepoetin

A

tx of anemia

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14
Q

these drugs prevent the binding of fibrinogen to the GP receptors on platelet surfaces ; inhibit cyclooxygenase 1 or block GP or ADP receptors

A

platelet aggregation inhibitors

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15
Q

these drugs all act either directly or indirectly to convert plasminogen to plasmin; as clot dissolves It can attract free platelets and cause further thrombosis

A

thrombolytic drugs

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16
Q

this specific drug inhibits vitamin K epo-xide reductase ( enzyme that regenerates Vit K) ; takes hours to work and is reversible with Vit K admin

A

warfarin

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17
Q

Desirudin

A

anticoagulant ( direct thrombin inhibitor)

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18
Q

erythropoeitin

A

tx of anemia

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19
Q

these platelet aggreg. inh specific drugs also block the GP receptor ; IV only

A

Eptifibatide and Tirofiban

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20
Q

urokinase

A

thrombolytic agents

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21
Q

eptifibatide

A

Platelet Inhibitors

22
Q

bivalirudin

A

anticoagulant ( direct thrombin inhibitor)

23
Q

lepirudin

A

anticoagulant ( direct thrombin inhibitor)

24
Q

tenecteplase

A

thrombolytic agents

25
Q

argatroban

A

anticoagulant ( direct thrombin inhibitor)

26
Q

this thrombolytic drug forms active complex with plasminogen ; used within 4 hours of MI ; bleeding disorders common and is a foreign protein

A

streptokinase

27
Q

this anti bleeding med antagonizes agents that interfere with vitamin K

A

vitamin K

28
Q

enoxaparin

A

low molecular weight heparins

29
Q

aminocaproic acid

A

tx of bleeding

30
Q

ticagrelor

A

Platelet Inhibitors

31
Q

tirofiban

A

Platelet Inhibitors

32
Q

this platelet aggre. inh drug is a coronary vasodilator; it increases cAMP levels ; good in combo with other meds

A

dipyridamole

33
Q

these drugs either inhibit the action of coagulation factors or interfere with the synthesis of the coagulation factors

A

anticoagulants

34
Q

pentoxifylline

A

tx of sickle cell

35
Q

prasugrel

A

Platelet Inhibitors

36
Q

this thrombolytic drug binds to fibrin and converts tissue plasminogen to plasmin

A

tenecteplase

37
Q

this drug inhibits COX-1 ( impedes platelet aggregation) ;

A

aspirin

38
Q

hydroxyurea

A

tx of sickle cell

39
Q

dipyridamole

A

Platelet Inhibitors

40
Q

streptokinase

A

thrombolytic agents

41
Q

ticlopidine

A

Platelet Inhibitors

42
Q

clopidogrel ( Plavix)

A

Platelet Inhibitors

43
Q

this thromboylytic drug is a product of recombinant tech; it rapidly activates plasminogen that is bound to fibrin in a thrombus; bleeding complications can occur; improved outcome if admin,. within three hours of ischemic stroke

A

alteplase

44
Q

These drugs block ADP 2Y receptors ; inhibits expression of GP IIB/IIa receptors for fibrinogen

A

platelet aggregration inhibitors ( ticlopidine, Clopidogrel, Prasugrel, and Ticagrelor)

45
Q

Aspirin

A

Platelet Inhibitors

46
Q

alteplase

A

thrombolytic agents

47
Q

fondaparinux

A

anticoagulant ( Factor Xa inhibitor)

48
Q

this thrombolytic drug is produced by the kidneys; It directly cleaves the arginine- valine bond of plasminogen to yield plasmin; approved for lysis of pulmonary emboli

A

urokinase

49
Q

heparin

A

other anticoagulants

50
Q

this anti bleeding med antagonizes heparin

A

protamine

Pharmacology II (31 decks)

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