Blood Drugs to Know and MOA

Question 1

protamine

Answer 1

tx of bleeding

Question 2

Abciximab

Answer 2

Platelet Inhibitors

Question 3

dalteparin

Answer 3

low molecular weight heparins ( anticoagulant)

Question 4

these are all competitive , reversible inhibitors of thrombin

Answer 4

thrombin inhibitors

Question 5

this platelet aggregration inh drug is a chimeric monoclonal Ab; binds to GP receptor and blocks binding of fibrinogen; very expensive ; adverse effect of bleeding

Answer 5

abciximab

Question 6

warfarin ( Coumadin)

Answer 6

other anticoagulants

Question 7

this thrombin inhibitor drug binds to antithrombin III ; leads to rapid inactivation of thrombin and factor Xa; Low molecular weights/antithrombin III complex only inactivates factor Xa

Answer 7

thrombin inhibitors - heparin

Question 8

this anti bleeding med inhibits plasminogen activation

Answer 8

aminocaproic acid

Question 9

rivaroxaban

Answer 9

anticoagulant ( Factor Xa inhibitor)

Question 10

dabigatran ( pradaxa)

Answer 10

anticoagulant ( direct thrombin inhibitor)

Question 11

this platelet aggre. inh inhibits phosphodiesterase III ; prevents degradation of cAMP; adverse effects of HA and GI effects ; CI in pts with CHF

Answer 11

cilostazol

Question 12

reteplase

Answer 12

thrombolytic agents

Question 13

darbepoetin

Answer 13

tx of anemia

Question 14

these drugs prevent the binding of fibrinogen to the GP receptors on platelet surfaces ; inhibit cyclooxygenase 1 or block GP or ADP receptors

Answer 14

platelet aggregation inhibitors

Question 15

these drugs all act either directly or indirectly to convert plasminogen to plasmin; as clot dissolves It can attract free platelets and cause further thrombosis

Answer 15

thrombolytic drugs

Question 16

this specific drug inhibits vitamin K epo-xide reductase ( enzyme that regenerates Vit K) ; takes hours to work and is reversible with Vit K admin

Answer 16

warfarin

Question 17

Desirudin

Answer 17

anticoagulant ( direct thrombin inhibitor)

Question 18

erythropoeitin

Answer 18

tx of anemia

Question 19

these platelet aggreg. inh specific drugs also block the GP receptor ; IV only

Answer 19

Eptifibatide and Tirofiban

Question 20

urokinase

Answer 20

thrombolytic agents

Question 21

eptifibatide

Answer 21

Platelet Inhibitors

Question 22

bivalirudin

Answer 22

anticoagulant ( direct thrombin inhibitor)

Question 23

lepirudin

Answer 23

anticoagulant ( direct thrombin inhibitor)

Question 24

tenecteplase

Answer 24

thrombolytic agents

Question 25

argatroban

Answer 25

anticoagulant ( direct thrombin inhibitor)

Question 26

this thrombolytic drug forms active complex with plasminogen ; used within 4 hours of MI ; bleeding disorders common and is a foreign protein

Answer 26

streptokinase

Question 27

this anti bleeding med antagonizes agents that interfere with vitamin K

Answer 27

vitamin K

Question 28

enoxaparin

Answer 28

low molecular weight heparins

Question 29

aminocaproic acid

Answer 29

tx of bleeding

Question 30

ticagrelor

Answer 30

Platelet Inhibitors

Question 31

tirofiban

Answer 31

Platelet Inhibitors

Question 32

this platelet aggre. inh drug is a coronary vasodilator; it increases cAMP levels ; good in combo with other meds

Answer 32

dipyridamole

Question 33

these drugs either inhibit the action of coagulation factors or interfere with the synthesis of the coagulation factors

Answer 33

anticoagulants

Question 34

pentoxifylline

Answer 34

tx of sickle cell

Question 35

prasugrel

Answer 35

Platelet Inhibitors

Question 36

this thrombolytic drug binds to fibrin and converts tissue plasminogen to plasmin

Answer 36

tenecteplase

Question 37

this drug inhibits COX-1 ( impedes platelet aggregation) ;

Answer 37

aspirin

Question 38

hydroxyurea

Answer 38

tx of sickle cell

Question 39

dipyridamole

Answer 39

Platelet Inhibitors

Question 40

streptokinase

Answer 40

thrombolytic agents

Question 41

ticlopidine

Answer 41

Platelet Inhibitors

Question 42

clopidogrel ( Plavix)

Answer 42

Platelet Inhibitors

Question 43

this thromboylytic drug is a product of recombinant tech; it rapidly activates plasminogen that is bound to fibrin in a thrombus; bleeding complications can occur; improved outcome if admin,. within three hours of ischemic stroke

Answer 43

alteplase

Question 44

These drugs block ADP 2Y receptors ; inhibits expression of GP IIB/IIa receptors for fibrinogen

Answer 44

platelet aggregration inhibitors ( ticlopidine, Clopidogrel, Prasugrel, and Ticagrelor)

Question 45

Aspirin

Answer 45

Platelet Inhibitors

Question 46

alteplase

Answer 46

thrombolytic agents

Question 47

fondaparinux

Answer 47

anticoagulant ( Factor Xa inhibitor)

Question 48

this thrombolytic drug is produced by the kidneys; It directly cleaves the arginine- valine bond of plasminogen to yield plasmin; approved for lysis of pulmonary emboli

Answer 48

urokinase

Question 49

heparin

Answer 49

other anticoagulants

Question 50

this anti bleeding med antagonizes heparin

Answer 50

protamine