Drugs Targeting Central Noradrenergic and Serotonergic and MOA

Question 1

Escitalopram ( Lexapro)

Answer 1

Selective Serotonin Reuptake Inhibitor

Question 2

Nefazodone

Answer 2

Atypical Antidepressants

Question 3

Clomipramine

Answer 3

Tricyclic Antidepressant

Question 4

this specific atypical antidepressant drug enhances serotonin and NE neurotransmission> blocks presynaptic alpha 2 receptors ; potent antihistamine activity

Answer 4

mirtazapine

Question 5

Imipramine

Answer 5

Tricyclic Antidepressant

Question 6

Selegiline

Answer 6

Monoamine Oxidase Inhibitors

Question 7

Paroxetine ( Paxil)

Answer 7

Selective Serotonin Reuptake Inhibitor

Question 8

Amitriptyline

Answer 8

Tricyclic Antidepressant

Question 9

adverse effects of these drugs antagonize muscarinic, histamine, and adrenergic receptors; this leads to dry mouth, confusion, weight gain, blurred vision, increased IOP, sedation, and sexual dysfunction

Answer 9

Tricyclic antidepressants

Question 10

Sertraline ( Zoloft)

Answer 10

Selective Serotonin Reuptake Inhibitor

Question 11

Desipramine

Answer 11

Tricyclic Antidepressant

Question 12

Doxepin

Answer 12

Tricyclic Antidepressant

Question 13

Citalopram ( Celexa)

Answer 13

Selective Serotonin Reuptake Inhibitor

Question 14

Venlafaxine ( Effexor)

Answer 14

Serotonin /NE Reuptake Inhibitors

Question 15

Phenelzine

Answer 15

Monoamine Oxidase Inhibitors

Question 16

Fluoxetine ( Prozac)

Answer 16

Selective Serotonin Reuptake Inhibitor

Question 17

Mirtazapine

Answer 17

Atypical Antidepressants

Question 18

this class of drugs blocks the reuptake of NE and 5HT ( serotonin) ( inhibit transporter protein); differing selectivity; blocks other serotonergic, alpha adrenergic, histaminic and muscarinic receptors

Answer 18

Tricyclic Antidepressants

Question 19

Duloxetine ( Cymbalta)

Answer 19

Serotonin /NE Reuptake Inhibitors

Question 20

Tranylcypromine

Answer 20

Monoamine Oxidase Inhibitors

Question 21

this class of drugs inhibits the metabolism of NE, 5HT ( serotonin), and dopamine ; non specific; increases the effectiveness of synaptic transmission by increasing the amt of transmitter released per action potential

Answer 21

MAO inhibitors

Question 22

Nortriptyline

Answer 22

Tricyclic Antidepressant

Question 23

Trazodone

Answer 23

Atypical Antidepressants

Question 24

Protriptyline

Answer 24

Tricyclic Antidepressant

Question 25

Bupropion ( Wellbutrin, Zyban)

Answer 25

Atypical Antidepressants

Question 26

adverse effects of these drugs are less severe; dry mouth, GI distress, agitation, insomnia, sexual dysfunction

Answer 26

Serotonin Selective Reuptake Inhibitors

Question 27

these drugs block the reuptake of NE and 5HT

Answer 27

Serotonin/NE reuptake inhibitors

Question 28

adverse effects of this class of drugs includes orthostatic hypotension, serotonin syndrome, sleep disturbances, weight gain, blurred vision, dry mouth, and sexual dysfunction

Answer 28

MAO inhibitors

Question 29

this class of drugs blocks reuptake of serotonin (5HT) highly selective

Answer 29

Serotonin Selective Reuptake Inhibitors

Question 30

this specific atypical antidepressant drug is a weak dopamine and NE reuptake inhibitor; also assists in decreasing the craving and attenuating the withdrawal symptoms for nicotine; adverse effects include dry mouth, sweating, nervousness/tremor, increased risk for seizure

Answer 30

bupropion

Question 31

this specific atypical antidepressant drug are weak inhibitors of serotonin reuptake ; potent antihistamine activity ( sedative ); adverse effects are risk of hepatotoxicity , orthostasis, and dizziness

Answer 31

Trazodone and Nefadozone