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Pharmacology II > Anti-inflammatory Drugs > Flashcards

Anti-inflammatory Drugs Flashcards

1
Q

misoprostol

A

prostaglandin analogs

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2
Q

illoprost

A

prostaglandin analogs

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3
Q

latanoprost

A

prostaglandin analogs

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4
Q

travaprost

A

prostaglandin analogs

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5
Q

bimatoprost

A

prostaglandin analogs

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6
Q

Aspirin

A

NSAIDS

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7
Q

Celecoxib

A

NSAIDS

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8
Q

diclofenac

A

NSAIDS

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9
Q

diflunisal

A

NSAIDS

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10
Q

etodolac

A

NSAIDS

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11
Q

meclofenamate

A

NSAIDS

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12
Q

fenoprofen

A

NSAIDS

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13
Q

flurbiprofen

A

NSAIDS

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14
Q

ibuprofen

A

NSAIDS

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15
Q

indomethacin

A

NSAIDS

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16
Q

ketorolac

A

NSAIDS

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17
Q

meloxicam

A

NSAIDS

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18
Q

nabumetone

A

NSAIDS

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19
Q

naproxen

A

NSAIDS

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20
Q

oxaprozin

A

NSAIDS

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21
Q

piroxicam

A

NSAIDS

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22
Q

sulindac

A

NSAIDS

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23
Q

tolmetin

A

NSAIDS

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24
Q

acetaminophen

A

other analgesics

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25
Q

adalimumab

A

drugs for arthritis

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26
Q

anakinra

A

drugs for arthritis

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27
Q

certozilumab

A

drugs for arthritis

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28
Q

chloroquine

A

drugs for arthritis

29
Q

etanercept

A

drugs for arthritis

30
Q

gold salts

A

drugs for arthritis

31
Q

golimumab

A

drugs for arthritis

32
Q

infliximab

A

drugs for arthritis

33
Q

leflunomide

A

drugs for arthritis

34
Q

methotrexate

A

drugs for arthritis

35
Q

D penicillamine

A

drugs for arthritis

36
Q

these drugs act by inhibiting the production of prostaglandins

A

NSAIDS

37
Q

these drugs bind to cell membrane receptors and act as local signals to fine tune response of a specific cell type ; major role in modulating pain, inflammation, and fever

A

prostaglandins

38
Q

this specific drug is a PGE1 analog; its used to protect the mucosal lining of the stomach during chronic NSAID treatment ; also used for labor induction

A

misoprostol

39
Q

the MOA of this specific drug: interacts with prostaglandin receptors on parietal cells -> reduces gastric secretion and stimulates mucus and bicarbonate production

A

misoprostol

40
Q

this specific Drug has AE : potential risk to induce abortion, SE of diarrhea, ab pain, and HA

A

misoprostol

41
Q

this specific drug is an analog of prostacyclin; its a pulmonary vasodilator and is given via inhalation; MOA - activates prostacyclin receptors and increases production of cAMP

A

Iloprost

42
Q

SE of this specific drug include dizziness, HA, and flushing

A

Iloprost

43
Q

these three drugs MOA is they bind to prostaglandin FP receptors and increase uveoscleral outflow -> reduction of IOP;

A

latanoprost, travoprost, and bimatoprost

44
Q

AE of these three drugs includes : blurred vision, increased iris pigmentation, increased number and pigment of eyelashes, eye redness, and irritation

A

latanoprost, travoprost, and bimatoprost

45
Q

these drugs act by inhibiting cyclooxygenase enzymes -> leads to decrease prostaglandin synthesis

A

NSAIDS

46
Q

this drug is a prototype of traditional NSAIDS; it irreversibly inactivates cyclooxygenase ; serves as an anti-inflammatory, and as an analgesic , serves as an antipyretic, increases alveolar ventilation, GI effects, and as a blood thinner

A

aspirin

47
Q

some AE of this drug includes GI prob like nausea, GI bleeding; increased bleeding time, hypersensitivity to allergens ; can cause Reyes Syndrome; and has many drug interactions

A

aspirin

48
Q

which drug is preferential for COX-2

A

meloxicam ( nonselective at high doses)

49
Q

which NSAID is a potent analgesic commonly used after Cat Sx to reduce pain and macular edema

A

ketorolac

50
Q

this drug is sig. more selective for COX2 and allows for better mgmt. of chronic pain

A

celecoxib

51
Q

this drug is not an NSAID, it inhibits prostaglandin synthesis in the CNS ; good antipyretic and analgesic

A

acetaminophen

52
Q

this drug is the drug of choice for children with viral infections or chickenpox; serves as a substitute for NSAID

A

acetaminophen

53
Q

this drug doesn’t have many side effects at normal doses; high doses can cause hepatic necrosis

A

acetaminophen

54
Q

this specific drug is an immunosuppressant ; used for RA treatment

A

methotrexate

55
Q

this specific drug is used for RA; it decreases pyrimidine synthesis in lymphocytes (causes cell arrest) ; AE of HA, diarrhea, and nausea, has flu like symptoms and is CI in pregnancy

A

leflunomide

56
Q

this specific drug inhibits phospholipase A2; also anti- malarial and has ocular SE such as bulls eye maculopathy

A

hydroxychloroquine

57
Q

this drug has MOA that’s unclear; usually combined with hydroxychloroquine and methotrexate

A

sulfasalazine

58
Q

this drug is a analog of cysteine; slows progression of bone destruction and RA; used in combo with NSAIDs or glucocorticoids ; short term Tx

A

D-peniciollamine

59
Q

this drug is taken up by macrophages to suppress phagocytosis and lysosomal enzyme activity ; used infrequently due to severe SE

A

gold salts

60
Q

this drug is metabolized to 6- Mercaptopurine in the liver ; has mutagenic potential and is CI in pregnancy or breast feeding

A

azathioprine

61
Q

this drug is also an alkylating agent, it has cytotoxic effects on both B and T cells ; selectively suppresses B lymphocyte activity ; teratogenic activity

A

cyclophosphamide

62
Q

these drugs antagonize the inflammatory effects of TNF and IL-1 cytokines ; they decrease symptoms of RA

A

TNF inhibitors

63
Q

AE of these drugs includes : increased risk of infection, worsening of pre-existing heart failure, increased risk of lymphoma and other cancers

A

TNF inhibitors

64
Q

this drug is a IL-1 Antagonist; it can be combined with other therapies except TNF inhibitors ; subcutaneous injection

A

IL-1 antagonist

65
Q

these drugs are used in the Tx of RA; they slow the course of disease and induce remission

A

DMARDs

66
Q

what is the oral formulation of Gold Salts

A

auranofin

67
Q

which drugs are used to “ bridge the time “ until DMARDs are effective

A

glucocorticoids

68
Q

what are the pro-inflammatory cytokines involved in RA

A

IL-1 and TNF alpha

69
Q

this drug is an IL-1 antagonist and it can be combined with other therapies except TNF inhibitors; requires subcutaneous injections

A

anakinra

Pharmacology II (31 decks)

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