Anti-inflammatory Drugs Flashcards
misoprostol
prostaglandin analogs
illoprost
prostaglandin analogs
latanoprost
prostaglandin analogs
travaprost
prostaglandin analogs
bimatoprost
prostaglandin analogs
Aspirin
NSAIDS
Celecoxib
NSAIDS
diclofenac
NSAIDS
diflunisal
NSAIDS
etodolac
NSAIDS
meclofenamate
NSAIDS
fenoprofen
NSAIDS
flurbiprofen
NSAIDS
ibuprofen
NSAIDS
indomethacin
NSAIDS
ketorolac
NSAIDS
meloxicam
NSAIDS
nabumetone
NSAIDS
naproxen
NSAIDS
oxaprozin
NSAIDS
piroxicam
NSAIDS
sulindac
NSAIDS
tolmetin
NSAIDS
acetaminophen
other analgesics
adalimumab
drugs for arthritis
anakinra
drugs for arthritis
certozilumab
drugs for arthritis
chloroquine
drugs for arthritis
etanercept
drugs for arthritis
gold salts
drugs for arthritis
golimumab
drugs for arthritis
infliximab
drugs for arthritis
leflunomide
drugs for arthritis
methotrexate
drugs for arthritis
D penicillamine
drugs for arthritis
these drugs act by inhibiting the production of prostaglandins
NSAIDS
these drugs bind to cell membrane receptors and act as local signals to fine tune response of a specific cell type ; major role in modulating pain, inflammation, and fever
prostaglandins
this specific drug is a PGE1 analog; its used to protect the mucosal lining of the stomach during chronic NSAID treatment ; also used for labor induction
misoprostol
the MOA of this specific drug: interacts with prostaglandin receptors on parietal cells -> reduces gastric secretion and stimulates mucus and bicarbonate production
misoprostol
this specific Drug has AE : potential risk to induce abortion, SE of diarrhea, ab pain, and HA
misoprostol
this specific drug is an analog of prostacyclin; its a pulmonary vasodilator and is given via inhalation; MOA - activates prostacyclin receptors and increases production of cAMP
Iloprost
SE of this specific drug include dizziness, HA, and flushing
Iloprost
these three drugs MOA is they bind to prostaglandin FP receptors and increase uveoscleral outflow -> reduction of IOP;
latanoprost, travoprost, and bimatoprost
AE of these three drugs includes : blurred vision, increased iris pigmentation, increased number and pigment of eyelashes, eye redness, and irritation
latanoprost, travoprost, and bimatoprost
these drugs act by inhibiting cyclooxygenase enzymes -> leads to decrease prostaglandin synthesis
NSAIDS
this drug is a prototype of traditional NSAIDS; it irreversibly inactivates cyclooxygenase ; serves as an anti-inflammatory, and as an analgesic , serves as an antipyretic, increases alveolar ventilation, GI effects, and as a blood thinner
aspirin
some AE of this drug includes GI prob like nausea, GI bleeding; increased bleeding time, hypersensitivity to allergens ; can cause Reyes Syndrome; and has many drug interactions
aspirin
which drug is preferential for COX-2
meloxicam ( nonselective at high doses)
which NSAID is a potent analgesic commonly used after Cat Sx to reduce pain and macular edema
ketorolac
this drug is sig. more selective for COX2 and allows for better mgmt. of chronic pain
celecoxib
this drug is not an NSAID, it inhibits prostaglandin synthesis in the CNS ; good antipyretic and analgesic
acetaminophen
this drug is the drug of choice for children with viral infections or chickenpox; serves as a substitute for NSAID
acetaminophen
this drug doesn’t have many side effects at normal doses; high doses can cause hepatic necrosis
acetaminophen
this specific drug is an immunosuppressant ; used for RA treatment
methotrexate
this specific drug is used for RA; it decreases pyrimidine synthesis in lymphocytes (causes cell arrest) ; AE of HA, diarrhea, and nausea, has flu like symptoms and is CI in pregnancy
leflunomide
this specific drug inhibits phospholipase A2; also anti- malarial and has ocular SE such as bulls eye maculopathy
hydroxychloroquine
this drug has MOA that’s unclear; usually combined with hydroxychloroquine and methotrexate
sulfasalazine
this drug is a analog of cysteine; slows progression of bone destruction and RA; used in combo with NSAIDs or glucocorticoids ; short term Tx
D-peniciollamine
this drug is taken up by macrophages to suppress phagocytosis and lysosomal enzyme activity ; used infrequently due to severe SE
gold salts
this drug is metabolized to 6- Mercaptopurine in the liver ; has mutagenic potential and is CI in pregnancy or breast feeding
azathioprine
this drug is also an alkylating agent, it has cytotoxic effects on both B and T cells ; selectively suppresses B lymphocyte activity ; teratogenic activity
cyclophosphamide
these drugs antagonize the inflammatory effects of TNF and IL-1 cytokines ; they decrease symptoms of RA
TNF inhibitors
AE of these drugs includes : increased risk of infection, worsening of pre-existing heart failure, increased risk of lymphoma and other cancers
TNF inhibitors
this drug is a IL-1 Antagonist; it can be combined with other therapies except TNF inhibitors ; subcutaneous injection
IL-1 antagonist
these drugs are used in the Tx of RA; they slow the course of disease and induce remission
DMARDs
what is the oral formulation of Gold Salts
auranofin
which drugs are used to “ bridge the time “ until DMARDs are effective
glucocorticoids
what are the pro-inflammatory cytokines involved in RA
IL-1 and TNF alpha
this drug is an IL-1 antagonist and it can be combined with other therapies except TNF inhibitors; requires subcutaneous injections
anakinra
