Anti-inflammatory Drugs Flashcards
1
Q
misoprostol
A
prostaglandin analogs
2
Q
illoprost
A
prostaglandin analogs
3
Q
latanoprost
A
prostaglandin analogs
4
Q
travaprost
A
prostaglandin analogs
5
Q
bimatoprost
A
prostaglandin analogs
6
Q
Aspirin
A
NSAIDS
7
Q
Celecoxib
A
NSAIDS
8
Q
diclofenac
A
NSAIDS
9
Q
diflunisal
A
NSAIDS
10
Q
etodolac
A
NSAIDS
11
Q
meclofenamate
A
NSAIDS
12
Q
fenoprofen
A
NSAIDS
13
Q
flurbiprofen
A
NSAIDS
14
Q
ibuprofen
A
NSAIDS
15
Q
indomethacin
A
NSAIDS
16
Q
ketorolac
A
NSAIDS
17
Q
meloxicam
A
NSAIDS
18
Q
nabumetone
A
NSAIDS
19
Q
naproxen
A
NSAIDS
20
Q
oxaprozin
A
NSAIDS
21
Q
piroxicam
A
NSAIDS
22
Q
sulindac
A
NSAIDS
23
Q
tolmetin
A
NSAIDS
24
Q
acetaminophen
A
other analgesics
25
adalimumab
drugs for arthritis
26
anakinra
drugs for arthritis
27
certozilumab
drugs for arthritis
28
chloroquine
drugs for arthritis
29
etanercept
drugs for arthritis
30
gold salts
drugs for arthritis
31
golimumab
drugs for arthritis
32
infliximab
drugs for arthritis
33
leflunomide
drugs for arthritis
34
methotrexate
drugs for arthritis
35
D penicillamine
drugs for arthritis
36
these drugs act by inhibiting the production of prostaglandins
NSAIDS
37
these drugs bind to cell membrane receptors and act as local signals to fine tune response of a specific cell type ; major role in modulating pain, inflammation, and fever
prostaglandins
38
this specific drug is a PGE1 analog; its used to protect the mucosal lining of the stomach during chronic NSAID treatment ; also used for labor induction
misoprostol
39
the MOA of this specific drug: interacts with prostaglandin receptors on parietal cells -> reduces gastric secretion and stimulates mucus and bicarbonate production
misoprostol
40
this specific Drug has AE : potential risk to induce abortion, SE of diarrhea, ab pain, and HA
misoprostol
41
this specific drug is an analog of prostacyclin; its a pulmonary vasodilator and is given via inhalation; MOA - activates prostacyclin receptors and increases production of cAMP
Iloprost
42
SE of this specific drug include dizziness, HA, and flushing
Iloprost
43
these three drugs MOA is they bind to prostaglandin FP receptors and increase uveoscleral outflow -> reduction of IOP;
latanoprost, travoprost, and bimatoprost
44
AE of these three drugs includes : blurred vision, increased iris pigmentation, increased number and pigment of eyelashes, eye redness, and irritation
latanoprost, travoprost, and bimatoprost
45
these drugs act by inhibiting cyclooxygenase enzymes -> leads to decrease prostaglandin synthesis
NSAIDS
46
this drug is a prototype of traditional NSAIDS; it irreversibly inactivates cyclooxygenase ; serves as an anti-inflammatory, and as an analgesic , serves as an antipyretic, increases alveolar ventilation, GI effects, and as a blood thinner
aspirin
47
some AE of this drug includes GI prob like nausea, GI bleeding; increased bleeding time, hypersensitivity to allergens ; can cause Reyes Syndrome; and has many drug interactions
aspirin
48
which drug is preferential for COX-2
meloxicam ( nonselective at high doses)
49
which NSAID is a potent analgesic commonly used after Cat Sx to reduce pain and macular edema
ketorolac
50
this drug is sig. more selective for COX2 and allows for better mgmt. of chronic pain
celecoxib
51
this drug is not an NSAID, it inhibits prostaglandin synthesis in the CNS ; good antipyretic and analgesic
acetaminophen
52
this drug is the drug of choice for children with viral infections or chickenpox; serves as a substitute for NSAID
acetaminophen
53
this drug doesn't have many side effects at normal doses; high doses can cause hepatic necrosis
acetaminophen
54
this specific drug is an immunosuppressant ; used for RA treatment
methotrexate
55
this specific drug is used for RA; it decreases pyrimidine synthesis in lymphocytes (causes cell arrest) ; AE of HA, diarrhea, and nausea, has flu like symptoms and is CI in pregnancy
leflunomide
56
this specific drug inhibits phospholipase A2; also anti- malarial and has ocular SE such as bulls eye maculopathy
hydroxychloroquine
57
this drug has MOA that's unclear; usually combined with hydroxychloroquine and methotrexate
sulfasalazine
58
this drug is a analog of cysteine; slows progression of bone destruction and RA; used in combo with NSAIDs or glucocorticoids ; short term Tx
D-peniciollamine
59
this drug is taken up by macrophages to suppress phagocytosis and lysosomal enzyme activity ; used infrequently due to severe SE
gold salts
60
this drug is metabolized to 6- Mercaptopurine in the liver ; has mutagenic potential and is CI in pregnancy or breast feeding
azathioprine
61
this drug is also an alkylating agent, it has cytotoxic effects on both B and T cells ; selectively suppresses B lymphocyte activity ; teratogenic activity
cyclophosphamide
62
these drugs antagonize the inflammatory effects of TNF and IL-1 cytokines ; they decrease symptoms of RA
TNF inhibitors
63
AE of these drugs includes : increased risk of infection, worsening of pre-existing heart failure, increased risk of lymphoma and other cancers
TNF inhibitors
64
this drug is a IL-1 Antagonist; it can be combined with other therapies except TNF inhibitors ; subcutaneous injection
IL-1 antagonist
65
these drugs are used in the Tx of RA; they slow the course of disease and induce remission
DMARDs
66
what is the oral formulation of Gold Salts
auranofin
67
which drugs are used to " bridge the time " until DMARDs are effective
glucocorticoids
68
what are the pro-inflammatory cytokines involved in RA
IL-1 and TNF alpha
69
this drug is an IL-1 antagonist and it can be combined with other therapies except TNF inhibitors; requires subcutaneous injections
anakinra
