Sedative Drugs Flashcards
barbiturates with long duration of action?
phenobarbital and mephobarbital
barbiturate with ultra short duration of action and used as anesthesia?
thiopental
barbiturates induce which enzymes?
cytochrome p450 enzymes
barbiturates bind to which receptors?
GABA
barbiturates increase … of Cl ion channel and hyperpolarization of neurons?
duration of opening
barbiturates exacerbate … ?
porphyria
benzodiazepines utilize the same receptors as …. ?
ethanol
full benzodiazepine agonist; conscious sedation; pre-medication for dental or minor surgery?
midazolam
structurally not related to BZD; partial agonist of 5-HT receptors; affinity for D2 receptors?
buspirone
what can block the effect of buspirone?
flumazenil
a competitive antagonist at BZD binding site on the GABA receptor; short acting?
flumazenil
short acting BZD used for sleep disorders?
triazolam
intermediate acting BZD hypnotics?
temazepam and estazolam
long acting BZD hypnotic?
flurazepam
non BZD hypnotics for sleep disorders?
zolpidem, zaleplon, eszopiclone