Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Dental Pharmacology > Opioid Analgesics and Antagonists > Flashcards

Opioid Analgesics and Antagonists Flashcards

1
Q

Strong agonists?

A

fentanyl, sufentanil, hydromorphone, meperidine, morphine, methadone, buprenorphrine, oxymorphone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Moderate agonists?

A

codeine, oxycodone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Weak agonists?

A

propoxyphene, tramadol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Mixed agonists/antagonists?

A

pentazocine, nalbuphine, butorphanol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Antagonists?

A

naloxone, naltrexone, nalmefene

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Antitussives?

A

codeine, dextromethorphan, levopropoxyphene

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

opium resin contains 3 major alkaloids?

A

morphine, codeine, thebaine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

a 30 amino acid long peptide released from a precursor called POMC protein?

A

B-endorphin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

2 pentapeptides (enkephalins)?

A

Met-enkephalin and Leu-enkephalin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

dynorphin A and dynorhpin B are produced from pro-dynorphin in ….?

A

the pituitary, hypothalamus, midbrain and striatum

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

opioid bind to ….?

A

mu, delta and kappa receptors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

morphine and other pure agonists have greater affinity for … and lower affinity for …?

A

mu

kappa and delta

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

neospinothalamic?

A

fast Adelta fibers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

paleospinothalamic?

A

slow C fibers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

CNS distribution of mu and kappa receptors?

A

cerebral cortex, striatum, hippocampus, dorsal horn, midbrain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

How is CNS distribution of delta receptor different?

A

amygdala instead of midbrain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

pharmacologic functions of mu receptors?

A

analgesia, sedation, miosis, euphoria, constipation, respiratory depression, pruritus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

pharmacologic functions of kappa receptors?

A

analgesia, sedation, miosis, dysphoria, micturition, diuresis, hallucinations

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

pharmacologic functions of delta receptors?

A

analgesia, emotion/reward, seizures (?)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

prototypic ligands of mu receptors?

A

morphine, methadone, endorphin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

prototypic ligands of kappa receptors?

A

dynorphin A and ethylketocyclazocine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

prototypic ligands of delta receptors?

A

enkephalins and deltorphin II

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

effects of morphine binding at mu?

A

agonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

effects of morphine binding at kappa?

A

agonist (weak)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

effects of buprenorphine binding at mu?

A

mixed agonist/antagonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

effects of buprenorphine binding at kappa?

A

antagonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

effects of buprenorphine binding at delta?

A

antagonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

effects of pentazocine binding at mu?

A

antagonist (weak)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

effects of pentazocine binding at kappa?

A

agonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

effects of nalbuphine binding at mu?

A

antagonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

effects of nalbuphine binding at kappa?

A

agonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

effects of nalaxone binding at mu?

A

antagonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

effects of nalaxone binding at kappa?

A

antagonist

34
Q

effects of nalaxone binding at delta?

A

antagonist (weak)

35
Q

which semi synthetic opioid drug is 40x more potent than morphine?

A

buprenorphine

36
Q

which synthetic opioid drug can be given to those who need pain managed for awhile?

37
Q

codeine is only … as potent as morphine?

38
Q

CNS depression of Morphine is enhanced by …

A

sedative-hypnotics, antipsychotic drugs, antidepressants

39
Q

… may interfere with opioid induced analgesia?

A

sedative-hypnotics

40
Q

opioids (esp. meperidine) are contraindicated with …

A

MAOI antidepressants

41
Q

CNS effect of morphine?

A

analgesia, euphoria, stupor or tupor

42
Q

morphine: respiratory center depression or excitation?

A

depression

43
Q

True or False: cough reflex center is depressed by morphine

44
Q

True or false: miosis by morphine

45
Q

1/10 potency of morphine; cough suppression; mild to moderate pain?

46
Q

1/2 the potency of morphine; mild to moderate pain and antitussive?

A

hydorcodone/dihydrocodone

47
Q

moderate to severe pain; 2x potency of morphine; high abuse potential; bioavailability 80%?

48
Q

combo of oxycodone w/ acetaminophen?

49
Q

severe pain relief (acute pain); high potency (7-10x ) at Mu receptor sites?

A

hydromorphone

50
Q

severe pain relief; 7x more potent than morphine?

A

oxymorphone

51
Q

first fully synthetic; 1/10 potency of morphine; respiratory depression in neonates?

A

meperidine

52
Q

nor-meperidine is …?

A

neurotoxic

53
Q

moderate to severe pain relief (traditional use); opiate dependence treatment?

A

buprenorphine

54
Q

buprenorphine and naloxone?

55
Q

severe pain relief; fully synthetic; most potent opioid?

56
Q

moderate to severe pain; mainstay of opiate dependence treatment; fully synthetic?

57
Q

moderate to severe pain; fully synthetic; atypical opioid; partially blocked by naloxone; inhibits reuptake of NE and 5-HT?

58
Q

opioid receptor antagonist; short duration of action; only injectable?

59
Q

opioid receptor antagonist; long duration of action?

60
Q

opioid receptor antagonist; long duration of action; long duration of action; reduces craving?

A

naltrexone

61
Q

routes of admin of fentanyl?

A

IM, IV, transdermal

62
Q

duration of action of fentanyl?

63
Q

elimination half life of fentanyl?

64
Q

does fentanyl have active metabolite?

65
Q

routes of admin of methadone?

A

oral and parenteral

66
Q

duration of action of methadone?

67
Q

elimination half life of methadone?

68
Q

does methadone have active metabolite?

69
Q

route of admin of propoxyphene?

70
Q

duration of action of propoxyphene?

71
Q

elimination half life of propoxyphene?

72
Q

does propoxyphene have active metabolite?

73
Q

route of admin of naloxone?

A

parenteral

74
Q

duration of action of naloxone?

75
Q

elimination half life of naloxone?

76
Q

does naloxone have active metabolite?

77
Q

route of admins of naltrexone?

78
Q

duration of action of naltrexone?

79
Q

elimination half life of naltrexone?

80
Q

does naltrexone have active metabolite?

81
Q

two opioid receptor agonists with no analgesic effects and used mainly as antidiarrheal?

A

diphenoxylate and loperamide

Dental Pharmacology (30 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions