Psychotic drugs and abuse

Question 1

CNS stimulants

Answer 1

methylxanthine derivatives (caffeine, theophylline), nicotine, amphetamine related drugs

Question 2

amphetamine related drugs

Answer 2

amphetamine, phentermine, methamphetamine, phenfluramine, methylphenidate, cocaine

Question 3

CNS depressants

Answer 3

opioids, marijuana, ethanol, barbiturates/benzodiazepines

Question 4

other psychoactive drugs and hallucinogens

Answer 4

LSD, mescaline, PCP

Question 5

caffeine blocks … receptors which increased dopamine transmission

Answer 5

adenosine

Question 6

caffeine inhibits … resulting in increased cAMP; mobilizes intracellular Ca

Answer 6

phosphodiesterase

Question 7

caffeine has … ionotropic and chronotropic effects at high doses (both harmful in some heart conditions)

Answer 7

positive

Question 8

activates cholinergic-nicotinic receptors in CNS and periphery, euphoria, arousal, improved memory and concentration, appetite suppression, inhibits MAO, highly addictive

Answer 8

nicotine

Question 9

nicotine … vessels; neg. effects on blood vessels

Answer 9

constricts

Question 10

drugs of choice for ADHD

Answer 10

amphetamine; methylphenidate

Question 11

used in weight reduction

Answer 11

phentermine; fenfluramine; diethylpropion; phendimetrazine

Question 12

treatment for narcolepsy

Answer 12

D-amphetamine and methylphenidate

Question 13

potent local anesthetic; vasoconstriction; powerful psychostimulant; dependence; activates sympathetic; increased alertness/motor activity; tachycardia/hypertension; pupillary dilation; potent dopamine agonist; euphoria; increased sex drive

Answer 13

cocaine

Question 14

direct activation of the endogenous reward system (dopamine); micro-strokes; withdrawal from depletion of NE and DA

Answer 14

cocaine

Question 15

most commonly abused opioids by general population

Answer 15

heroin; oxycodone; morphine

Question 16

most commonly abused opioid by health professionals

Answer 16

meperidine and fentanyl

Question 17

meperidine induces … pupils in tolerant individuals

Answer 17

dilated

Question 18

opioid overdose reversal

Answer 18

naloxone

Question 19

opioid dependence maintenance therapy

Answer 19

methadone

Question 20

THC

Answer 20

marijuana

Question 21

the endogenous ligand of cannabinoid receptor located in cerebellum, hippocampus and basal ganglia

Answer 21

anandomide

Question 22

anticholinergic-hallucinogenic drug of abuse

Answer 22

scopolamine (night shade plant)

Question 23

catecholamine like-hallucinogenic drugs of abuse

Answer 23

MDMA (ecstasy) and mescaline (Peyote)

Question 24

serotonin like-hallucinogenic drugs of abuse

Answer 24

LSD and psilocybin (mushroom)

Question 25

glutaminergic NMDA antagonists (hallucinogenic drugs of abuse)

Answer 25

PCP and ketamine

Question 26

pharmacologic treatment of amphetamine intoxication

Answer 26

lorazepam for agitation and haloperidol for psychosis

Question 27

pharmacologic treatment for BZDs

Answer 27

flumazenil

Question 28

pharmacologic treatment for cocaine

Answer 28

lorazepam for agitation or seizures

Question 29

pharmacologic treatment for hallucinogens

Answer 29

lorazepam for agitation

Question 30

pharmacologic treatment for marijuana

Answer 30

lorazepam for agitation

Question 31

pharmacologic treatment for opioids

Answer 31

naloxone

Question 32

pharmacologic treatment for PCP

Answer 32

lorazepam for agitation and haloperidol for psychosis