Asthma and COPD

Question 1

antiinflammatory drugs: inhaled steroids

Answer 1

budesonide; beclomethasone; fluticasone; mometasone; (ciclesonide)

Question 2

antiinflammatory drug: modulator of mast cell degranulation; mast cell stabilizer

Answer 2

cromolyn

Question 3

antiinflammatory drug: modulator of mast cell degranulation; anti-IgE

Answer 3

omalizumab

Question 4

leukotriene modifiers: leukotriene receptor antagonists

Answer 4

montelukast; (zafirlukast)

Question 5

leukotriene modifier: 5-LO (lipoxygenase) inhibitor

Answer 5

zileuton

Question 6

bronchodilators: short acting B2 agonists

Answer 6

albuterol; (levalbuterol); (pirbuterol)

Question 7

bronchodilators: long acting B2 agonists

Answer 7

salmeterol; formoterol; indacaterol

Question 8

bronchodilators: methylxanthines

Answer 8

theophylline; aminophylline

Question 9

bronchodilators: muscarinic receptor antagonists

Answer 9

ipratropium; tiotropium

Question 10

bronchodilator: PDE-4 inhibitor

Answer 10

roflumilast

Question 11

which bronchodilator should always be in your dental emergency kit?

Answer 11

albuterol

Question 12

Which receptors?: located in large bronchioles; vagal innervation

Answer 12

cholinergic (M2) receptors

Question 13

which receptors?: located in small bronchioles; no direct innervation

Answer 13

B2 receptors

Question 14

anticholinergic: inhaler: response varies: increased broncho-selectivity by poor mucosal and CNS uptake

Answer 14

ipratropium bromide

Question 15

anticholinergic: long duration of action: approved for COPD

Answer 15

tiotropium bromide

Question 16

2 x daily dosing long acting B2 agonists

Answer 16

salmeterol; formoterol

Question 17

1 x daily dosing long acting B2 agonist

Answer 17

indacaterol

Question 18

theophylline and diethylamine

Answer 18

aminophylline

Question 19

useful for allergic asthma; non-specific stabilizer of mast cell; inhibit cough by their action on airway nerves

Answer 19

cromolyn sodium

Question 20

oral corticosteriods

Answer 20

methylprednisolone, prednisolone

Question 21

“soft steroid”

Answer 21

ciclesonide

Question 22

the most effective agents for acute attacks unresponsive to bronchodilators; restores B receptor therapy

Answer 22

oral or parenteral glucocorticoids

Question 23

systemic effects of what?: decreased bone density in premenopausal women and decreased rate of growth in children

Answer 23

inhaled glucocorticoids

Question 24

CYP2CP and 3A4 inhibited by …

Answer 24

zafirlukast

Question 25

receptor blockers?

Answer 25

“kasts”

Question 26

synthesis blockers; inhibits leukotriene formation

Answer 26

zileuton

Question 27

prophylaxis of moderate to severe aeroallergen associated asthma; prevents binding of IgE to a variety of cells (mast cells) associated with allergic response; SC injection

Answer 27

omalizumab

Question 28

PDE4 inhibitor

Answer 28

roflumilast