IV Anesthetics Flashcards
induction agents?
thiopental, etomidate, propofol, methohexital
Which tends to produce depressing effects in specific areas?
ketamine
which tends to produce global depressing effects?
thiopental
affect GABA system?
barbiturates, benzodiazepines, etomidate
affects glutamate system?
ketamine
bifunctional activity: GABA and glutamate?
propofol
which class prolongs binding of GABA to receptor?
barbiturates
which class causes an allosteric change in GABA receptor activity?
benzodiazepines
which drug is the exception and increases CBF, ICP, MAP, CO?
ketamine
which drug neither stimulates nor inhibits the cardiovascular system?
etomidate
a barbiturate so increased cytrochrome P450 activity (increase metabolic activity; enzyme induction); porphyria?
thiopental
anitemitic qualities (induce vomiting)?
propofol
inhibition of steroidogenesis; not used in ICU?
etomidate
analgesic; IM route; intact pharyngeal and laryngeal reflexes; bronchodilator for refractory asthma; hallucinations (may require w/ benzodiazepine)?
ketamine
dissociative agent: eyes open but unconscious and pain free?
ketamine
which class of drug: anticonvulsant; amnesia; wide safety margin; minimal CV and respiratory depression; useful where no analgesia required?
benzodiazepines
specific antagonist of benzodiazepines?
flumazenil
3 benzodiazipines?
diazepam; lorazepam; midazolam
half life of diazepam?
20-40
half life of lorazepam?
10-20
half life of midazolam?
2-4
opioid antagonists?
naloxone; nalmefene
opioid overdose triad?
pinpoint pupils; decreased respiration; coma
a new opioid class w/ potent analgesic activity, rapid onset, short half life; non cumulative effects; rapid recovery?
remifentanil
long lasting opioid?
morphine
opioid: more lipid soluble; peak effect in 2-3 min; nausea and vomiting rare?
fentanyl
in malignant hyperthermia, which receptor is affected by the drug to cause dramatic release of calcium
ryanodine receptor
antidote to malignant hyperthermia?
dantrium
