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Dental Pharmacology > Antidepressants > Flashcards

Antidepressants Flashcards

1
Q

First Gen drugs

A

tricyclics and MAO inhibitors

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2
Q

2nd and 3rd Gen drugs

A

tetracyclics and unicyclics; 5-HT2 antagonists; SSRI; SNRI

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3
Q

drugs that inhibit 5-HT reuptake w/ greater potency but not technically SSRIs

A

trazodone and venlafaxine

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4
Q

drug that inhibits NE reuptake w/ greater potency

A

maprotiline

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5
Q

drugs that have little effect on re-uptake of either 5-HT or NE

A

bupropion and mirtazapine

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6
Q

tricyclic dibenzazepine tertiary amine

A

imipramine

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7
Q

tricyclic dibenzazepine secondary amine

A

desipramine

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8
Q

tricyclic dibenzocycloheptadiene tertiary amine

A

amitriptyline

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9
Q

tricyclic dibenzocycloheptadiene secondary amine

A

protriptyline

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10
Q

tricyclic dibenzoxepine tertiary amine

A

doxepine

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11
Q

probably primary action of alleviation of depression of TCAs

A

blockage of NE reuptake

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12
Q

sedative effects of TCAs are enhanced by …

A

CNS depressants

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13
Q

co-administration of TCAs with … can lead to sever hyperpyrexia, hypertension, tremors, convulsions, coma or death

A

MAOIs

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14
Q

inhibitors of cytochrome P450 … will increase concentration of TCAs

A

erythromycin, clarithromycin, fluoxetine

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15
Q

inducer of cyp-450

A

carbamazepine

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16
Q

MAOIs of both MAO A and B

A

phenelzine and trancylcypromine

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17
Q

located in gut and peripheral tissues; preferentially oxidizes 5-HT, but not NE or dopamine

A

MAO-A

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18
Q

located in platelets; preferentially metabolizes dopamine

A

MAO-B

19
Q

MAOIs block metabolism of … and other amines found in aged cheese, beer and chianti, may escalate levels of monoamines

A

L-dopa

20
Q

if MAOIs are given with other anti depressants (esp. SSRIs) may cause …

A

malignant serotonin syndrome

21
Q

1st clinically available atypical; tetracyclic; used to treat psychoses and mood disorders; blocks NE greater than 5-HT; sedation and may cause seizures

A

maprotiline

22
Q

N-demethylated metabolite of antipsychotic drug loxapine; action resembles secondary amine TCAs but also blocks dopamine and 5-HT2a; anticholinergic and parkinsons like side effects

A

amoxapine

23
Q

triazole derivatives; inhibition of 5-HT2a; weak re uptake inhibition of serotonin and NE; short plasma half life; treatment of depression, insomnia of SSRIs, panic attacks; sedation, CV side effects, priapism of males

A

trazodone and nefodazone

24
Q

aminoketone; weak inhibitor of NE, 5-HT and DA re-uptake; depression; smoking cessation; seasonal affective disorder; agitation; insomnia, anorexia and weight loss, seizures

A

bupropion

25
Q

blocks presynaptic A2 receptors; increases amine release by removing feed back inhibition; no effect on serotonin re uptake; CV effects (serious), sedation, dry mouth, blurred vision, weight gain

A

mirtazapine

26
Q

SSRIs

A

fluoxetine, sertraline, paroxetine, citalopram, escitalopram

27
Q

half life and daily dose of fluoxetine

A

70 and 20-80

28
Q

half life and daily dose of sertraline

A

25 and 50-200

29
Q

half life and daily dose of paroxetine

A

20 and 10-50

30
Q

half life and daily dose of citalopram/escitalopram

A

35 and 20-40

31
Q

fluoxetine taken with lithium, TCAs, warfarin

A

increased action of 2nd drug

32
Q

fluvoxamine taken with alprazolam, theophylline, TCAs and warfarin

A

increased blood levels of 2nd drug

33
Q

MAOIs taken with SSRIs, food containing tyramine

A

hypertensive crisis, serotonin syndrome

34
Q

nefazodone taken with alprazolam, triazolam

A

increased blood levels of 2nd drug

35
Q

paroxetine, sertraline taken with warfarin, TCAs

A

increased blood levels of 2nd drug

36
Q

TCAs taken with sedative/hypnotics, ethanol

A

increased CNS depression

37
Q

highly sedating

A

amitriptyline, doxepin, trazadone, mirtazapine

38
Q

anti muscarinic effects

A

amitriptyline and doxepin

39
Q

SSRIs generally lack … and are safe in overdose

A

sedating activities

40
Q

main line drug of bipolar disorder

A

lithium salts

41
Q

diabetes insipidus

A

chronic toxicity of lithium salts

42
Q

plasma levels of lithium are elevated by

A

thiazide diuretics (chlorothiazide) and ACE inhibitors (catopril)

43
Q

NSAIDs decrease …

A

renal excretion

44
Q

alcohol and caffeine promote …

A

lithium excretion

Dental Pharmacology (30 decks)

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