CHF Flashcards
ACE Is
captopril; enalapril; fosinopril
ARBs
losartan; valsartan; candesartan; irbesartan
B blockers approved for CHF
metoprolol, carvedilol, bisoprolol
a b blocker that potentiates NO in vasculature, is approved for hypertension but not CHF
nebivolol
aldosterone antagonists
spironolactone, eplerenone
MoA of which drug: increased intracellular availability of Ca for contractile apparatus via inhibition of Na/K ATPase
digoxin
Quinidine … plasma digoxin levels
increases
Amiodarone … digoxin levels by decreasing elimination
increases
… can cause slowing of heart rate and digoxin toxicity
veapamil
… with digoxin increase potential for arrhythmias due to hypokalemia
diuretics
… is a vasodilator that acts directly on the arterial s.m.
hydralazine
nitrates
nitroglycerin and nitroprusside
B agonist; B1>B2; also A1 agonist; positive inotrope; vasodilator; short term IV “bridge” or intermittant therapy
dobutamine
IV inotropic agent; phosphodiesterase inhibitors
milrinone
long term oral use of … in CHF increases mortality
PDE inhibitors