CHF

Question 1

ACE Is

Answer 1

captopril; enalapril; fosinopril

Question 2

ARBs

Answer 2

losartan; valsartan; candesartan; irbesartan

Question 3

B blockers approved for CHF

Answer 3

metoprolol, carvedilol, bisoprolol

Question 4

a b blocker that potentiates NO in vasculature, is approved for hypertension but not CHF

Answer 4

nebivolol

Question 5

aldosterone antagonists

Answer 5

spironolactone, eplerenone

Question 6

MoA of which drug: increased intracellular availability of Ca for contractile apparatus via inhibition of Na/K ATPase

Answer 6

digoxin

Question 7

Quinidine … plasma digoxin levels

Answer 7

increases

Question 8

Amiodarone … digoxin levels by decreasing elimination

Answer 8

increases

Question 9

… can cause slowing of heart rate and digoxin toxicity

Answer 9

veapamil

Question 10

… with digoxin increase potential for arrhythmias due to hypokalemia

Answer 10

diuretics

Question 11

… is a vasodilator that acts directly on the arterial s.m.

Answer 11

hydralazine

Question 12

nitrates

Answer 12

nitroglycerin and nitroprusside

Question 13

B agonist; B1>B2; also A1 agonist; positive inotrope; vasodilator; short term IV “bridge” or intermittant therapy

Answer 13

dobutamine

Question 14

IV inotropic agent; phosphodiesterase inhibitors

Answer 14

milrinone

Question 15

long term oral use of … in CHF increases mortality

Answer 15

PDE inhibitors

Question 16

B-type natriuretic peptide

Answer 16

nesiritide

Question 17

… oppose vasoconstrictors in CHF

Answer 17

natriuretic peptides