Rocuronium Bromide Flashcards
ROCURONIUM BROMIDE- Name
Zemeron
ROCURONIUM BROMIDE- Class
nondepolarizing neuromuscular blockade
ROCURONIUM BROMIDE- MoA
prevents acetylcholine from binding to receptors on the motor end plate, thus blocking action potential transmission, and muscle contraction.
ROCURONIUM BROMIDE- Indication
Rapid sequence intubation
pharmacologically assisted intubation.
ROCURONIUM BROMIDE- Contra
No absolute contraindications
ROCURONIUM BROMIDE- S/E
Cardiovascular: tachycardia, abnormal ECG, transient hypotension, edema
Respiratory: apnea, respiratory insufficiency, asthma, hiccups
GI: nausea, vomiting
Other: rash, injection site edema
ROCURONIUM BROMIDE- Routes
IV, IO
ROCURONIUM BROMIDE- A. Dose
0.6mg/kg to 1.2 mg/kg
Maintenance dose to maintain paralysis:
0.1-0.2 mg/kg
ROCURONIUM BROMIDE- P. Dose
0.6 mg/kg
Maintenance dose to maintain paralysis:
.075-0.125 mg/kg
ROCURONIUM BROMIDE- EXTRAS
Precautions: Use with caution in patients with hepatic disease, severe obesity, electrolyte disturbances, neuromuscular disease, and an altered circulation time caused by cardiovascular disease.
Interactions: Succinylcholine, tetracyclines, verapamil, anticonvulsants, beta-blockers, ketamine may enhance neuromuscular blockade, increasing skeletal muscle relaxation and potentiating the effects Carbamazepine and phenytoin may decrease the effect of rocuronium, may need to increase the dose.
In most patients, tracheal intubation may be performed within 2 minutes; muscle paralysis should last for about 31 minutes.
Note for pediatric patients: tracheal intubation can be performed in about 1 minute and paralysis can last as long as 41 minutes.
Notes: Please ensure adequate support of the airway when giving this drug, both during the administration and for the 30-40 minutes that the paralysis may remain.
