Amiodarone

Question 1

Amio- names

Answer 1

Cordarone, Pacerone

Question 2

Amio- class

Answer 2

Antidysrhythmic

Question 3

Amio- MoA

Answer 3

Prolongs duration of action potential and refractory period without significantly effecting the resting potential

Relaxes smooth muscles causing vasodilation (especially in the coronary arteries)

Raises the threshold for VFIB

Question 4

Amio- Indications

Answer 4

Monomorphic VTAC (wide and fat)

Pulseless VTAC/VFIB refractory to defibrillation attempts

Symptomatic PVC’s

Question 5

Amio- Contra

Answer 5

C.B.S.

Cardiogenic shock

Bradycardia

Sick Sinus Syndrom

Question 6

Amio- S/E

Answer 6

Cardiovascular: cardiogenic shock, hypotension, bradycardia, CHF

Neuro: muscle weakness, tingling/numbness, dizziness, headache

Resp: pulmonary toxicity

Question 7

Amio- Routes

Answer 7

IV, IO, IVPB

Question 8

Amio- A. Dose

Answer 8

**Arrest: **300 mg IVP/IO followed by 10-20 ml NS flush 150 mg IVP/IO followed by 10-20 ml NS flush in 3-5 minutes if no conversion

Wide-complex Tachycardia/symptomatic PVC’s: 150 mg slow IVP/IO over 10 minutes (max dose 450 mg)

Maintenance Infusion (IVPB): 0.5 mg per minute for post conversion (540 mg over 18 hours)

Question 9

Amio- P. Dose

Answer 9

VTAC/ VFIB Arrest: 5 mg/kg IVP/IO followed by 10 ml NS flush, max dose is 15 mg/kg

Tachydysrhythmias: 5 mg/kg IVP/IO over 20-60 minutes max dose 15 mg/kg

Question 10

Amio- EXTRAs

Answer 10

Precautions: Hypersensitivity to iodine Incompatible with Sodium Bicarbonate, Heparin and Aminophylline

Significantly increases digoxin levels and phenytoin (Dilantin®㋿) levels

Has long elimination half-life – remains in circulation commonly for 40-55 days or more.