Amyl Nitrite

Question 1

AMYL NITRITE- Name

Answer 1

Vaporole

Question 2

AMYL NITRITE- Class

Answer 2

Nitrate vasodilator

Antidote

Question 3

AMYL NITRITE- MoA

Answer 3

Relaxes vascular smooth muscle, decreasing vascular resistance (decreases preload and afterload)

Converts hemoglobin to methemoglobin, which then binds with cyanide to form non-toxic cyanomethemoglobin that can be excreted

Question 4

AMYL NITRITE- Indication

Answer 4

Angina Hypertension

Cyanide poisoning

Question 5

AMYL NITRITE- Contra

Answer 5

Hypotension

Erectile Dysfunction (PDE 5 inhibitors) medications within the last 36 hours

No contraindications when being used to treat cyanide poisoning

Question 6

AMYL NITRITE- S/E

Answer 6

Cardiovascular: hypotension, tachycardia, palpitations, cardiovascular collapse

CNS: headache, dizziness, weakness

Respiratory: respiratory depression

Question 7

AMYL NITRITE- Routes

Answer 7

Inhalation

Question 8

AMYL NITRITE- A. Dose

Answer 8

1-2 ampules (0.3 ml),

crushed and inhaled over 30 seconds

May repeat every 1-2 minutes

Question 9

AMYL NITRITE- P. Dose

Answer 9

1 ampule (0.3 ml),

crushed and inhaled for 15-30 seconds

May repeat every 1-2 minutes

Question 10

AMYL NITRITE- EXTRAS

Answer 10

Precautions:

Pregnancy

Shock

Tendency for abuse

Interactions:

Hypotensive effects will be potentiated with other vasodilators such as ACE-inhibitors, beta blockers, narcotics, certain phenothiazines and other nitrates

Onset in 10-30 seconds and may last 3-5 minutes

Notes: High flow oxygen should be administered in between doses