Labetalol Flashcards
Labetalol- Name
Normodyne
Trandate
Labetalol- Class
Alpha and Beta Adrenergic Blocking Agent
Labetalol- MoA
Combines selective alpha and non selective beta adrenergic blocking actions. Both activities serve to reduce blood pressure.
- Alpha Blockade leads to: vasodilation, decreased peripheral resistance, and orthostatic hypotension.
- Beta Blockade leads to: effects on SA, AV nodes, and ventricular muscle that leads to bradycardia, delay in AV conduction and depression of cardiac contractility.
Labetalol- Indications
Alone or in combination with other drugs to control Hypertension
Hypertensive Emergencies
Labetalol- Contra
23BBCC
2nd or 3rd degree heart block
bradycardia
bronchial asthma
Cardiogenic shock
cardiac failure
Labetalol- S/E
Cardiovascular: postural hypotension, angina, palpitations, bradycardia, syncope, CHF
CNS: Dizziness, vertigo, numbness, somnolence, Tingling of the scalp or skin
Respiratory: Dyspnea, bronchospasm
Miscellaneous: flushing, sweating,
Labetalol- Routes
IVPB, IV, IO (can also be seen in PO form for home medication)
Labetalol- A. Dose
20 mg slow IV push
with 40-80 mg every 10 minutes,
to a max dose of 300 mg total
OR
2 mg/min continuous IVPB,
to a total max dose of 300 mg
Labetalol- P. Dose
Safety in children has not been established – not recommended.
Labetalol- EXTRAS
Precautions: Use with caution during lactation, in impaired renal or hepatic function, in chronic bronchitis and emphysema, and in diabetes (may block signs of hypoglycemia), efficacy and safety in children has not been established.
Interactions:
beta-adrenergic bronchodilators ( i.e. Albuterol) – Labetalol decreases the bronchodilator effect of these drugs
Cimetidine (i.e. Tagamet): increases circulating labetalol levels
Tricyclic Antidepressants (i.e. Elavil, Tofranil) – increased risk of tremors
Do NOT use with IV calcium channel blockers.
Onset and Duration of Action: PO: 2-4 hrs, peak at 2-4 hrs, lasting 8-12 hours. IV: 5 minutes, lasting 90 minutes to 4 hours.
Notes: Monitor patient position changes, especially ambulating and upright positions, as labetalol often causes postural hypotension.