Reteplase

Question 1

Reteplase- Name

Answer 1

Retavase

Question 2

Reteplase- Class

Answer 2

Thrombolytic

Question 3

Reteplase- MoA

Answer 3

Plasminogen activator that catalyzes cleavage of endogenous plasminogen to generate plasmin, this degrades the thrombus matrix, causing thrombolysis.

Question 4

Reteplase- Indication

Answer 4

Acute Myocardial Infarction (AMI)

Occlusive stroke

Question 5

Reteplase- Contra

Answer 5

Active internal bleeding

Aneurysm

Brain tumor

History of hemorrhagic stroke

Severe uncontrolled hypertension

Recent surgery or trauma

Question 6

Reteplase- S/E

Answer 6

Cardiovascular: hemorrhage, embolism, CHF, ventricular fibrillation, cardiac arrest, cardiac tamponade

Question 7

Reteplase- Routes

Answer 7

IV, IO

Question 8

Reteplase- A. Dose

Answer 8

10 Units over 2 minutes with a single repeat in 30 minutes

Question 9

Reteplase- P. Dose

Answer 9

not recommended

Question 10

Reteplase- EXTRAS

Answer 10

Precautions: Lactation

Interactions: Use in combination with other anticoagulants may increase bleeding

Onset in 10-15 minutes and may last 30 minutes

Should anaphylaxis occur, stop administration and treat for reaction and any reperfusion dysrhythmias