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pharmacology > respiratory unit B > Flashcards

respiratory unit B Flashcards

1
Q

Short Acting Beta 2-agonists

A

Albuterol
Levalbuterol
Xopenex
Ventolin

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2
Q

Long-acting Beta 2 agonists

A

Formoterol (can be both long and short)
Perforomist
Serevent
Almeterol

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3
Q

MOA of beta 2- agonists

A

Activation of beta adrenergic receptors leads to relaxation of smooth muscle in the lung, and dilation and opening of the airways.

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4
Q

Inhaled Corticosteroids

A

Flovent (fluticasone propionate)
Budesonide
Arnuity (fluticasone furoate)

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5
Q

MOA of inhaled corticosteroids

A

Inhibits multiple inflammatory cytokines, produces multiple glucocorticoid and mineralocorticoid effects

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6
Q

Common combination inhaler for asthma

A

Advair (salmeterol/fluticasone)

LABA/Corticosteroid

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7
Q

Mast Cell Stabilizer

A

Cromolyn

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8
Q

Is cromolyn used for acute symptoms?

A

No. It is used for prophylaxis in asthma

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9
Q

Leukotriene Receptor Antagonists

A

Accolate (Zafirlukast)

Singulair (montelukast)

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10
Q

Leukotrine inhibitor

A

Zileuton

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11
Q

Contraindications of Zileuton

A

Acute liver disease

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12
Q

D2D interactions with Zileuton

A

Do not use with propranolol, theophylline, or warfarin

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13
Q

Inhaled LAMA approved for asthma in patients older than 6

A

tiotropium bromide

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14
Q

Three-drug inhaler for use in COPD and Asthma

A

Trelegy Ellipta
(Fluticasone furoate/umeclidinum/vilanterol)
ICS/LAMA/LABA

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15
Q

what inhaler cannot be used alone when treating asthma?

A

LABA - salmeterol - (Serevent)

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16
Q

Can you use LABAs alone when treating COPD

A

Yes

17
Q

MOA of Xolair (omalizumab)

A

Subq injection - Inhibits IgE binding to IgE receptors on mast cells and basophils

18
Q

BBW for Omalizumab (Xolair)

A

Anaphylaxis and bronchospasm

19
Q

IL-5 Receptor antagonist

A

Reslizumab (Cinqair)

decreases production of eosinophils

20
Q

Used as an add-on agent for asthma due to eosinophila

A

Cinqair (reslizumab)

21
Q

Can lead to immunogenicity and anaphylaxis

A

IL-5 Receptor antagonists (Cinquair)

BBW - anaphylaxis

22
Q

Examples of monoclonal antibodies used for asthma

A

Anti-IgE antibody (Xolair omalizumab)
IL-5 receptor antagonists (Cinqair reslizumab)
IL-4 Receptor Alpha Antagonists (Dupixent dupilumab)

pharmacology (26 decks)

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