respiratory unit B Flashcards
Short Acting Beta 2-agonists
Albuterol
Levalbuterol
Xopenex
Ventolin
Long-acting Beta 2 agonists
Formoterol (can be both long and short)
Perforomist
Serevent
Almeterol
MOA of beta 2- agonists
Activation of beta adrenergic receptors leads to relaxation of smooth muscle in the lung, and dilation and opening of the airways.
Inhaled Corticosteroids
Flovent (fluticasone propionate)
Budesonide
Arnuity (fluticasone furoate)
MOA of inhaled corticosteroids
Inhibits multiple inflammatory cytokines, produces multiple glucocorticoid and mineralocorticoid effects
Common combination inhaler for asthma
Advair (salmeterol/fluticasone)
LABA/Corticosteroid
Mast Cell Stabilizer
Cromolyn
Is cromolyn used for acute symptoms?
No. It is used for prophylaxis in asthma
Leukotriene Receptor Antagonists
Accolate (Zafirlukast)
Singulair (montelukast)
Leukotrine inhibitor
Zileuton
Contraindications of Zileuton
Acute liver disease
D2D interactions with Zileuton
Do not use with propranolol, theophylline, or warfarin
Inhaled LAMA approved for asthma in patients older than 6
tiotropium bromide
Three-drug inhaler for use in COPD and Asthma
Trelegy Ellipta
(Fluticasone furoate/umeclidinum/vilanterol)
ICS/LAMA/LABA
what inhaler cannot be used alone when treating asthma?
LABA - salmeterol - (Serevent)
Can you use LABAs alone when treating COPD
Yes
MOA of Xolair (omalizumab)
Subq injection - Inhibits IgE binding to IgE receptors on mast cells and basophils
BBW for Omalizumab (Xolair)
Anaphylaxis and bronchospasm
IL-5 Receptor antagonist
Reslizumab (Cinqair)
decreases production of eosinophils
Used as an add-on agent for asthma due to eosinophila
Cinqair (reslizumab)
Can lead to immunogenicity and anaphylaxis
IL-5 Receptor antagonists (Cinquair)
BBW - anaphylaxis
Examples of monoclonal antibodies used for asthma
Anti-IgE antibody (Xolair omalizumab)
IL-5 receptor antagonists (Cinqair reslizumab)
IL-4 Receptor Alpha Antagonists (Dupixent dupilumab)
