Module 4 Unit C

Question 1

MOA of warfarin

Answer 1

Inhibits enzyme needed to convert vitamin K into active form, resulting in decreased production of factors VII, IX, X and prothrombin ultimately decreased fibrin formation.

Question 2

heparin and other anticoagulants BBW

Answer 2

Risk for spinal or epidural hematoma

Question 3

Low-molecular weight heparin

Answer 3

Lovenox (enoxaparin)

Fragmin (dalteparin)

Question 4

Direct oral anticoagulant

Answer 4

Dabigatran (Pradaxa)

Question 5

Indicated for prevention of stroke/embolism after surgery

Answer 5

Anticoagulants:
Direct thrombin inhibitor (Pradaxa)
Direct factor Xa inhibitor (Xarelto, Eliquis, Bevyxxa, Savaysa)

Question 6

MOA of Heparin and its derivatives

Answer 6

Activate antithrombin causing a reduction in fibrin and clotting

Question 7

what do we need to monitor with heparin use?

Answer 7

activated partial thromboplastin time (aPTT)

Question 8

Antidote for Lovenox

Answer 8

Protamine sulfate

Question 9

Monitor for _____ with Lovenox

Answer 9

hyperkalemia

thrombocytopenia

Question 10

what is HIT

Answer 10

heparin-induced thrombocytopenia (antibody-mediated coagulopathy leading to increased thrombus events)

Question 11

Herbal interactions with warfarin

Answer 11

“G” herbs - garlic, ginger, ginkgo, ginseng, green tea, fish oil

Question 12

Drugs that increase warfarin’s effect

Answer 12

Amiodarone, antiplatelets, NSAIDs, Macrolides, thyroid, sulfa, tetracyclines

Question 13

drugs that decrease warfarin’s effect

Answer 13

Rifampin, Isoniazid

Question 14

when to start warfarin at a lower dose

Answer 14

elderly
Heart Failure
malnourished
Liver disease
certain drugs.....and more