Module 9 Dermatology Unit A

Question 1

virus responsible for venereal warts

Answer 1

HPV: HPV-6 and HPV-11 are most common

Question 2

acyclovir MOA

Answer 2

inhibits viral replication by suppressing viral DNA

Question 3

Podophyllin MOA

Answer 3

inhibits DNA synthesis and mitosis leading to cellular death and erosion of the wart

Question 4

Must be applied by health care providder

Answer 4

Podophyllin
Bichloroacetic acid (BCA)
Trichloroacetic acid (TCA)

Question 5

Adverse effects of podphyllin

Answer 5

highly caustic and can lead to systemic absorption leading to toxicity.

Question 6

MOA of TCA and BCA

Answer 6

Destroys warts by chemical coagulation

Question 7

Intensifies the immune response by stimulating production of interferon alpha, TNF, and interleukins

Answer 7

Imiquimod (Aldara)

Question 8

systemic effects are not a concern with this topical ointment used for venereal warts

Answer 8

Imiquimod

Question 9

ointments that can be used at home to treat venereal warts

Answer 9

Imiquimod (Aldara, Zyclara)
Podofilox (Conylox)
Kunecatechins (sinecatechins/Veregen)

Question 10

Treatment for Acne Rosacea

Answer 10

Metronidazole (Flagyl)

Question 11

Avoid alcohol to avoid disulfiram-like reaction

Answer 11

Metronidazole

Question 12

How does spironolactone help treat acne

Answer 12

It blocks androgen production inhibiting sebaceous gland activity

Question 13

Baseline labs before starting spironolactone

Answer 13

potassium, CBC, CMP

Question 14

BBW for Retin-A and Accutane (tretinoins)

Answer 14

Teratogenic - structural and cognitive defects in fetus, increased risk for spontaneous abortion

Question 15

topical antibiotics

Answer 15

bacitracin

erythromycin

Question 16

Treatment for urticaria (hives)

Answer 16

Start with oral antihistamine like Zyrtec, then move on to oral steroid if needed

Question 17

length of treatment for topical corticosteroids

Answer 17

Adults: 2 weeks
Children: 1 week

Question 18

Prolongs QT interval

Answer 18

Fluconazole

Question 19

MOA of fluconazole

Answer 19

Impair synthesis of ergosterol allowing for increased permeability and leakage of cellular components resulting in cell death

Question 20

Drug to drug interactions with “azoles” fluconazole

Answer 20

inhibits CYP450, so will increase the effects of warfarin, theophylline, macrolides, statins, etc…

Question 21

Treatment for tinea capitis

Answer 21

griseofulvin

Question 22

Monitor liver function

Answer 22

griseofulvin

Question 23

oral agents for tinea unguium

Answer 23

“azoles” - monitor liver function - takes up to 6 months for toenails and 3 months for fingernails

Question 24

Most common treatment for second-degree burns

Answer 24

Silver sulfadiazine

Question 25

Other treatments for burns

Answer 25

Cooling and hydration

any antibacterial cream such as Polymix B or bacitracin