final exam part 3

Question 1

clarithromycin and calcium channel blockers

Answer 1

cause severe kidney injury

Question 2

antibiotics that increase risk for aortic aneurysm, especially in elderly and CV disease

Answer 2

fluoroquinolone

Question 3

serious side effect of fluoroquinolone

Answer 3

decreased blood sugar

mental health side effects

Question 4

safety with MAOIs

Answer 4

avoid foods with tyramine (fermented, cheese, wine)

wash out period of two weeks before starting another antidepressant

Question 5

Safety with TCAs (amitriptyline)

Answer 5

anticholinergic

Avoid with CV - risk of cardiac toxicity, dysrhythmias

Question 6

BBW for Prozac (and other SSRIs)

Answer 6

Suicidal ideation in children and teens

Question 7

BBW for 2nd generation antipsychotics

olanzapine, aripirazole

Answer 7

Agranulocytosis

myocarditis

Question 8

safe antidepressant for pregnancy

Answer 8

Prozac

Question 9

CNS drugs contraindicated in pregnancy

Answer 9

benzos
rozerem
phenytoin
depatkote (succinimide)

Question 10

safety with 1st generation antipsychotics

Haldol

Answer 10

EPS side effects

prolong QT interval

Question 11

BBW for Tegretol

carbamazepine

Answer 11

May cause SJS, TEN, agranulocytosis

Question 12

Safety and BBW with Tegretol (carbamezapine)

Answer 12

Bone marrow suppression
SJS, TEN
Aplastic anemia
agranulocytosis
Many D2D interactions - especially OC and folic acid

Question 13

BBW for phenytoin (dilantin)

Answer 13

Rapid IV administration can cause severe hypotension and cardiac dysrhythmias

Question 14

BBW for Depakote, lamictal (succinimide)

Answer 14

Liver failure, pancreatitis, teratogenic

Question 15

cholinesterase inhibitor that can prolong QT

Answer 15

Aricept (donepezil)

Question 16

anti-seizure meds to add calcium and Vitamin D due to calcium loss and increased risk for fracture

Answer 16

carbamazepine, phenytoin, valproate

Question 17

Risk of causing severe GI bleed with this combination

Answer 17

SSRI and NSAIDs

Question 18

BBW for inhaled insulin

Answer 18

bronchospasm in patients with asthma and COPD

Question 19

BBW for metformin

Answer 19

lactic acidosis

Hold 48 hours before and after contrast dye

Question 20

serious D2D interaction with metformin

Answer 20

cimetidine (tagamet) causes increased metformin increasing risk for lactic acidosis

Question 21

sulfonylureas safety

glipizide

Answer 21

NO pregnancy

stimulate insulin secretion - can cause hypoglycemia

Question 22

antidiabetics safe in pregnancy

Answer 22

insulin

metformin

Question 23

BBW for Saxenda

Answer 23

thyroid CA

Question 24

BBW for levothyroxine

Answer 24

Do not use for weight loss, risk of toxicity

Question 25

warfarin and levothyroxin

Answer 25

reduce warfarin dose if starting thyroid replacement

Question 26

levothyroxine with insulin or digoxin

Answer 26

increase doses of insulin and digoxin if starting thyroid replacement

Question 27

Testosterone BBW

Answer 27

secondary exposure to children

Increase risk of CV events, microembolism

Question 28

BBW for Selective estrogen receptor modulators (SERMs)/Evista

Answer 28

Thromboembolic events

Question 29

BBW for DMARDs

Answer 29

serious infections and malignancy

Question 30

other safety for DMARDs

methotrexate, infliximab, hydroxychloroquine

Answer 30

screen for Hepatitis B and C
screen for TB
May cause active TB

Question 31

BBW for Byetta (GLP-1 receptor agonist)

Answer 31

thyroid tumors in rats

Question 32

BBW for tretinoins

Answer 32

Teratogenic, increased risk for spontaneous abortion

Question 33

antifungal that prolongs QT

Answer 33

fluconazole