Module 8 Unit A Diabetes 2

Question 1

diabetic drug to drug interactions

Answer 1

Other diabetic meds
Hyperglycemic agents (steroids, epinephrine, etc.)
beta-adrenergic blockers

Question 2

BBW for metformin (biguanide)

Answer 2

Lactic acidosis

Question 3

safety with metformin

Answer 3

hold metformin for 48 hours after any IV contrast to reduce stress on kidneys and void metformin build up.

Question 4

Monitoring for metformin

Answer 4

check GFR at least annually

Question 5

side effects of metformin

Answer 5

GI: Nausea, vomiting, diarrhea. Metalic taste in mouth

Question 6

drug to drug interactions with metformin

Answer 6

tegretol (cimetidine) results in increased metformin levels

Question 7

MOA of sulfonylureas

Answer 7

Increase insulin sensitivity

stimulate insulin secretion

Question 8

advantages of metformin

Answer 8

does not cause weight gain

does not lead to hypoglycemia

Question 9

BBW of metformin

Answer 9

lactic acidosis

Question 10

sulfonylureas

Answer 10

glipizide

glimeperide

Question 11

Main concern with sulfonylureas

Answer 11

hypoglycemia (especially in long-acting ones in the elderly)

Question 12

side effects of sulonylureas

Answer 12

nausea, skin reactions, abnormal LFTs, weight gain

Question 13

MOA of thiazolidinediones

Answer 13

Redistribute fat from the visceral compartment to the subcutaneous compartment .

Question 14

BBW for thiazolidinediones (Actos/Avandia)

Answer 14

May cause or exacerbate heart failure

Question 15

MOA of meglitinides (Repaglinide/Prandin)

Answer 15

Stimulate insulin release from beta cells.

Question 16

Sodium/glucose cotransporter 2 (SGLT2)

Answer 16

“gliflozins”

Question 17

Benefit of SGLT2

Answer 17

Used in patients with atherosclerotic CV risk factors, CHF, or diabetic kidney disease Safe on heart and kidneys