Module 4 Unit B Flashcards
Target of HMG-CoA Reductase Inhibitors (Statins)
Lower the low-density lipoprotein (LDL) levels
Contraindicated statin use
Pregnancy, lactation, active liver disease, large alcohol use, CYP3A4 inhibitors like clarithromycin.
People at risk for rhabdomyoloysis
Renal impairment Hypothyroidism colchicine use Vitamin D deficiency Coenzyme-Q deficiencies Older than 65
Drug with highest risk of rhabdomyolysis
simvastatin
Statin with lowest risk of rhabdomyolysis
fluvastatin (Lescol)
pravastatin (Pravachol)
What labs need to be monitored with statin therapy? And when?
Start monitoring labs 4-12 weeks into therapy. Check liver enzymes, creatine kinase
Down side to Bile Acid Sequestrants
They can elevate triglyceride levels
Side effects of bile acid sequestrants
flatulence, bloating, heartburn, constipation
Must be taken with meals because they block cholesterol reabsorption from food
Bile acid sequestrants
take one hour before or 4 hours after other meds
Bile acid sequestrants
May decrease absorption of fat-soluble vitamins
Bile acid sequestrants
Inhibitor of low density lipoprotein levels. Must be given subcutaneously every two weeks
PCSK9 inhibitors
Example of PCSK9 inhibitor
Allrocumab (proluent)
Evolocumab (repatha)
Example of bile acid sequestrants
Colesevelam (Welchol)
Fibric Acid Derivative
Gemfibrozil (Lopid)
Fenofibrate (Tricor)
