GI - unit C

Question 1

Abdominal pain and altered bowel habits in the absence of specific and unique organic pathology

Answer 1

IBS (irritable bowel syndrome)

Question 2

Nonspecific Drugs for treatment of IBS

Answer 2

Bulk-Forming agents
peppermint oil
antibiotics
Tricyclic antidepressants
SSRIs

Question 3

Indicated for treating women with severe IBS-D

Answer 3

Alosetron (Lotronex)

Question 4

How does Alosetron (Lotronex) work?

Answer 4

Blocks 5-HT receptors - decreased Abdominal pain, increase colon transit time, reduces intestinal secretions, increases water resorption

Question 5

BBW for Lotronex

Answer 5

Ischemic colitis

Question 6

Used for IBS-D in men and women

Answer 6

Eluxadoline (Viberzil)

Question 7

How does Eluxadoline (Viberzil) work?

Answer 7

Mu- and kappa receptor agonist - decreases motility of the bowel

Question 8

Used for IBS-C in women

Answer 8

Lubiprostone (Amitiza)

Question 9

MOA for Lubiprostone (Amitiza)

Answer 9

Selectively activates chloride channels increasing motility of colon

Question 10

Effective to reduce ABD, distention, flatulence in patients with IBS

Answer 10

Peppermint oil

Question 11

MOA of peppermint oil

Answer 11

antispasmodic effect on intestinal smooth muscles.

Question 12

Drug classes used to treat IBD

Answer 12

5-aminosalicylates
glucocorticoids
immunosuppressants
immunomodulators
antibiotics

Question 13

Severe adverse effect of sulfasalazine (5-aminosalicylate)

Answer 13

hematologic problems

less severe - nausea, fever, rash, arthralgia

Question 14

Antibiotics used for IBD

Answer 14

Flagyl

Cipro

Question 15

Immunosuppressants for IBD

Answer 15

thiopurines
cyclosporin
methotrexate

Question 16

Immunomodulator for IBD

Answer 16

Infliximab (remicade)

Question 17

Target specific parts of the immune system

Answer 17

Biologics

Question 18

example of immunosuppressant

Answer 18

thiopurines - azathioprine mercaptopurine
cyclosporine
methotrexate

Question 19

example of 5-aminosalicylate

Answer 19

Sulfasalazine

Question 20

example of immunomodulator

Answer 20

Infliximab (remicade)

Question 21

monoclonal antibody designed to neutralize TNF-a

Answer 21

Remicade (Infliximab)