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Pharmacology & Drugs > Respiratory Drugs- HIV > Flashcards

Respiratory Drugs- HIV Flashcards

1
Q

Enfuvirtide

A

Fusion inhibitor

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2
Q

Fosamprenavir

A

Protease inhibitor

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3
Q

Tipranavir

A

Protease inhibitor

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4
Q

Metabolism of etravirine

A

Inducer of 3A4

Inhibitor of 2C9 and 2C19

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5
Q

Adverse effects of Zidovudine

A

Blood issues as macrocytic anemia and neutropenia

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6
Q

Adverse effects of efavirenz

A

CNS issues such as drowsiness and dizziness

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7
Q

Darunavir

A

Protease inhibitor

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8
Q

Adverse effects of darunavir

A

Sulfa allergies

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9
Q

What is required with elvitegravir

A

Booster with cobicistat

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10
Q

Zanamivir

A

Anti-influenza

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11
Q

Nevirapine

A

non-NRTI in pregnant mothers and to the neonate

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12
Q

What must darunavir be coadministered with

A

Ritonavir or cobicistat

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13
Q

Protease inhibitor for pregnant women

A

Atazanavir

Darunavir

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14
Q

MOA of entry inhibitors

A

Binds to CCR5 to prevent the entry

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15
Q

Metabolism of elvitegravir

A

CYP3A4

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16
Q

Delaviridine

A

non-NRTI

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17
Q

When is lopinavir used

A

Combinationn with ritonavir as a booster

-In pregnant women

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18
Q

Peramivir

A

Anti-influenza

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19
Q

Benfits of enfuvirtide

A

None drug drug interactions

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20
Q

Efavirenz

A

non-NRTI

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21
Q

Adverse effects of Fosamprenavir

A

Sulfa allergies

headache, neausea, diarrhea

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22
Q

Oseltamivir

A

Anti-influenza

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23
Q

Fosamprenavir

A

Protease inhibitor

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24
Q

MOA or protease inhibitors

A

Blocks protease that allows mature vision

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25
Q

Etravirine

A

Diarylpyrimidine non-NRTI

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26
Q

Didanosine

A

Deoxyadenoxine NRTIs

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27
Q

Adverse effects and resistant mechanism of al NRTIs

A

Mito toxicity

Point mutations in RT

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28
Q

MOA for Peranivir

A

Inhibits neuromenidase

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29
Q

What are the boosting agents and how do they work

A

Ritonavir
• Cobicistat

Affect CYP3A4

30
Q

Maraviroc

A

Entry inhibitors

31
Q

When is dolutegravir used

A

Treatment of naive pts with:
1- tenofovir/emtricitabine or
2-abacavir/lamivudine

32
Q

Metabosism of protease inhibitors

A

CYP3A4

33
Q

Metabolism of Efavirenz

A

CYP3A4 and 2B6

34
Q

Metabolism of delavirdine

A

CYP3A4 and 2D6

35
Q

Atazanavir

A

Protease inhibitor

36
Q

Nelfinavir

A

Protease inhibitor

37
Q

What is commonly used as a booster with Saqyunavir

A

Ritonavir to reduce toxicities

38
Q

MOA of non-NRTI

A

Binds directly to RT resulting in allosteric inhibiton

39
Q

MOA of integrase strand transfer inhibitor

A

Prevents integration into the host DNA

40
Q

Ritonavir

A

Protease inhibitor

41
Q

MOA for oseltamivir

A

Inhibits neuormenidase

42
Q

Stavudine

A

Thymidine NRTIs

43
Q

Zidovudine

A

Deoxythymidine NRTIs

44
Q

Adverse affects of delavirdine

A

Skin rash and pregnancy effects

45
Q

Adverse effects of protease inhibitors

A

GI intolerance

-lipid changes such as hyperglycemia, hyperlipidemia, fat redistribution, cushing like symptoms

46
Q

What other condition is treated with emtricitabine and lamivudine

A

HBV

47
Q

Rilpivirine

A

Diarylpyrimidine non-NRTI in pregnanct women

48
Q

Lopinavir

A

Protease inhibitor

49
Q

Adverse effects of Nelfinavir

A

Gas

50
Q

MOA for Zanamivir

A

Inhibits neuromenidase

51
Q

Indinavir

A

Protease inhibitor

52
Q

Adverse effects of tiranavir

A

Sulfa allergy
Maculopapular rash
D/N/V

53
Q

Adverse effects of stavudine

A

Sensory neuropathy especially in immunosuppression pt

54
Q

Emtricitabine

A

Fluoridated version of lamivudine NRTIs

55
Q

Dolutegravir

A

Integrase strand transfer inhibitor

56
Q

Adverse effects of Indinavir

A

Unconjugated hyperbilirubinemia and nephrolithisasis (must drung water to prevent)

57
Q

What mutation would grant resistance against maraviroc

A

V3 loop of gp120

58
Q

Abacavir

A

Guanosine NRTIs

59
Q

Adverse effects of emtricitabine

A

Hyperpigmentation if palms and soles

60
Q

MOA of fusion inhibitors

A

Binds to gp41 and prevents binding and fusion with cell membrane

61
Q

Saquinavir

A

Protease inhibitor

62
Q

When is ritonavir used

A

As a booster due to its inhibition of 3A4 and GI issues

63
Q

Tenofovir

A

Acyclic adenosine NRTIs

64
Q

Lamivudine

A

Cytosine NRTIs

65
Q

When is raltegravir recommended

A

Naive persions with HAART and Pregnancy

66
Q

Elvitegravir

A

Integratse strand transfer inhibitor

67
Q

Pharmokinetics and adverse effects of enfuvirtide

A

SubQ bid, reactions at injection site

68
Q

Raltegravir

A

Integrase strand transfer inhibitor

69
Q

When is Tiranavir

A

When resistance to other Protease inhibitors

70
Q

Adverse effects of didanosine

A

Pancreatitis (especially with alcohol abuse, hyperTAGs)

Retinal changes and optic neuritis

Pharmacology & Drugs (43 decks)

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