Respiratory Drugs- COPD and asthma Flashcards
Mometasone
Inhaled corticosteroids
interactions with fluticasone
Strong inhibitor of 3A4
May increase chances of systemic corticosteroid effects
Albuterol
Short Acting Beta Agonist
Uses for triamcinolone
Prophylactic for asthma, can also be used to weene off systemic corticosteroids
Zafirlukast
Leukotriene inhibitor
Salmeterol
Long Acting Beta Agonist
Tiotropium
Anticholinergic
Use of budesonide
Maintenice of asthma in >6
MOA of Zafirlukast
Antagonist of D4 and E4, components of slow reacting anaphylaxis
What are the drug drug interactions of Zileuton
Increases theophylline levels, warfarin levels, propranolol levels and beta blocker activity
Uses for pirbuterol
Prevention and reversal of bronhcospasms in patients >12
Acilinium
Anticholinergic
When is terbutaline used
Prophylaxis for ages >12
Uses of olodaterol
Once daily for COPD
Uses for fluticasone
Prophylactic for younger than 4 years old
Uses for metaproterenolol
Bronchodilation for asthma or COPD
Use of Zafirlukast
Prophylaxis and chronic treatment of asthma in adults and children >5
Beclomethasone
Inhaled corticosteroids
What is the method of administration for terbutaline
IV
Metabolism of salmeterol
3A4
What is the adverse effect with beclomethasone
Care when transferring from systemic corticosteroids due to death from adrenal insufficiency. It takes time for the axis to recover
Ipratropium
Anticholinergic
Uses of indacaterol
COPD`
What are the adverse effects of Zafirlukast
Hepatotoxicity
Pirbuterol
Beta agonist
MOA for Monelukast
Selectively binds to CysLT1 receptor, inhibiting D4 without any agonist activity.
Olodaterol
Long Acting Beta Agonist
Ciclesonide
Inhaled corticosteroids
Adverse effects of Fomoterol
Asthma related deaths and hospitalizations if not already on a long term controller of asthma
What is a risk for all long Acting Beta Agonist
Increased risk for asthma related deaths and hospitalizations
Use for Monelukast
Allergies and prevention of asthma attacks
Cautions of budesonide
Milk allergies or where primary treatment of status asthmaticus or acute episodes where intenstive measures are needed
Fluticasone
Inhaled corticosteroid
Use of salmeterol
Asthma in pts >4, exercise induced asthma, maintenence of COPD
Adverse effects of metaproterenolol
CV negative effects
Theophylline
Methylxanthines
Fomoterol
Long Acting Beta Agonist
Indacaterol
Long Acting Beta Agonist
Uses for mometasone
Asthma prophylactic in patients >4
Triamcinolone
Inhaled corticosteroid
Metabolism of budesonide
CYP3A4
Budesonide
Inhaled corticosteroids
MOA of Zileuton
Inhibitor of 5-lipoxygenase, so all of B4,C4,D4,E4
Use for levalbuterol
Prevention or treatment of bronhcospasms in pt >4
Flunosolide
Inhaled corticosteroids
Omalizumab
Monoclonal antibody to IgE
Use for fomoterol
Treatment of asthma >5 yrs old, as an add on to long term corticosteroids, prevention of excersice induced asthma, treatment of COPD
What is the drug interactionwith zafirlukast
Coadministration with Warfarin will increase the prothrombin time
Montelukast
Leukotriene antagonist
Uses for Omalizumab
Severe asthma in pts older than 6, chonic idiopathic urticaria
3 methods of bronchodilation
- B2 agonsts
- Anticholinergic
- Methlyxanthines
Adverse effects of salmeterol
Severe allergies to milk
Patients must be on concurrent use of inhaled corticosteroid
Terbutaline
Beta Agonist
Levalbuterol
Beta agonist
Zileuton
Leukotriene antagonist
What conditions are contraindicated for theophylline
Active Peptic ulcer disease
seizure diseases
cardiac arrhythmias
What are the adverse effects of tiotropium
- Not for acute use or rescue medication
- Immediate hypersentitivity risk, especialy with milk protieins
Use for ciclesonide
Prophalayxis for >12 yrs old
Effects of methylxanthines
Broncho dilation
suppression of the airway responses
Uses for flunosolide
Maintenance of asthma in >6 years old, and in those trying to weene off of oral corticosteroids
Adverse effects of Zileuton
Pharynolaryngeal pain, elevation of hepatic enzymes
Metaoroterenol
Beta agonist
