Neuro-Autonomic Drugs Flashcards
Which family of drugs contain acebutolol
Beta 1 blocker
Does edrophonium cross into the CNS
No
What is the location of target receptor for estrogens
Nuclear estrogen receptors
What is homatropine used to treat
Ophthalmology
What is Trihexyphenidyl used to treat
Movement disorders such as tremors and rigidity in Parkinson’s (M1 antagonist)
Which family of drugs contain tiotropium
Antimuscarinic
What is procyclidine used to treat
Movement disorders
Which family of drugs contain cyclopentolate
Antimuscarinic
Which family of drugs contain Acetylcholine
Direct acting Cholinomimetics
Which family of drugs contain dicyclomine
Antimuscarinic
Which family of GPCR ligands contains histamine
Biogenic amines
Which family of GPCR ligands contains prostacyclin
Lipids
Which family of drugs contain hyoscyamine
Antimuscarinic
What are the side affects of alpha blockers
Orthostatic hypotension
Reflex induced tachycardia
Which family of drugs contain dobutamine
Beta agonists
What is the target for spiralactone
Antagonist for aldosterone receptor
Which family of drugs contain ephedrine
Increased release and direct adrenergic receptor agonists
Which family of drugs contain nadolol
Beta 1 and 2 blockers
What is the target for succinylcholine
Antagonist at NMJ
Which family of GPCR ligands contains opioids
Peptides/proteins
What is the result of using etoposide
Causes DNA, activation of p53 and apoptosis
What type of receptor is used to transmit Leptin
JAKSTAT
What is the target for digoxin
Sodium/potassium pump
Which drug is used for cardiogenic shock
Dopamine
Dobutamine
What is solifenacin used to treat
Urinary disorders (selective M3 antagonist)
Which family of GPCR ligands contains ADP
Nucleotides
Which family of drugs contain procyclidine
Antimuscarinic
What conditions is bethanechol used to treat
Non obstructive GI issues
Non obstructive urinary issues
Which antimuscarinic drug is used for a longer time of action
Tiotropium (M3 antagonist)
Which family of drugs contain Trihexyphenidyl
Antimuscarinic
What type of receptor is used to transmit erythropoietin
JAKSTAT
Which family of drugs contain Physostigmine
Cholinesterase inhibitors
What is neostigmine used to treat
Myasthenia gravis
Reverse nondepolarizing NMJ agents (curare)
Urinary retention
What is the location of target receptor for progesterone
Nuclear progesterone receptors
Which family of drugs contain fesoterodine
Antimuscarinic
What is methacholine used for
An asthma challenge for pulmonary testing
Which family of drugs contain tolterodine
Antimuscarinic
Which family of drugs contain selegiline
Inhibators of MAO
What is the location of target receptor for glucocorticoid
Nuclear glucocorticoid receptors
What is ritodrine used to treat
Premature labor
Which family of drugs contain Atropine
Antimuscarinic
Which family of drugs contain isoproterenol
Beta agonist
Which family of drugs contain Scopolamine
Antimuscarinic
Which family of drugs contain methacholine
Direct acting cholinomimetics
Which family of drugs contain fenoldopam
Dopamine agonists
What is phyridostimgine used to treat
Long term treatment for myasthenia gravis
What is carbachol used to treat
Acute angle glaucoma
Which family of GPCR ligands contains norepinephrine
Biogenic amines
What is tropicamide used to treat
Ophthalmology
Which family of drugs contain penylephrine
Alpha antagonist (alpha 1)
Which family of drugs contain tropicamide
Antimuscarinic
Which family of drugs contain oxybutynin
Antimuscarinic
Which family of GPCR ligands contains Thromboxane A2
Lipids
What is the overall result of bethanechol
Increased secretion of gut and urinary tract
What type of receptor is used to transmit NGF
Tyrosine kinase
Which family of drugs contain darifenacin
Antimuscarinic
What is Dicyclomine used to treat
Gastrointestinal disorders
What type of receptor is used to transmit PDGF
Tyrosine kinase
Which family of drugs contain pilocarpine
Direct acting cholinomimetics
What class of drug is given for prevention of premature labor
Beta 2 agonist
What is varenicline used to treat
Cessation of smoking
Which family of drugs contain Pyridostigmine
Cholinesterase Inhibators
Which family of drugs contain norepinephrine
Alpha and Beta agonists
What type of receptor is used to transmit IGF-1
Tyrosine Kinase
Which family of GPCR ligands contains Epinephrine
Biogenic amines
Which class of drug is given for glaucoma
Alpha 2 agonist
What type of receptor is used to transmit EGF
Tyrosine kinase
What is phenylephrine used to treat
-nasal congestion
-ophthalmology
-
Which family of drugs contain Echothiophate
Cholinesterase Inhibitors
What is dobutamine used to treat
Beta 1 > beta 2
Increased heart rate, contractility, CO
What are the treatments for bronchial asthma
Beta-2 agonists
Albuterol
Terbutaline
What is tolterodine used to treat
Adult urinary incontinence (M2 antagonist)
Which family of drugs contain atenolol
Beta 1 blockers
What type of receptor is used to transmit interleukin 2-10,15
JAKSTAT
Which family of drugs contain betaxolol
Beta 1 blockers
Which family of drugs contain Pralidoxime
Cholinesterase regenerator
What is the mechanism of action of Prazosin
Alpha 1 Adrenergic receptor antagonist
Which drug should not be given for a depolarizing NMJ blocking agent
Acetylcholine esterase inhibitor
What type of drug class is propranolol
Beta blocker
What is the property of binding and target for phenoxybenzamine
Irreversible binding to alpha receptors
Which family of drugs contain phentolamine
Nonselective alpha 1 and 2 antagonist
Which family of GPCR ligands contains Acetylcholine
Biogenic amines
Which family of drugs contain Galantamine
Cholinesterase Inhibators
Which family of GPCR ligands contains Glutamate
Aminoacids
What is biperiden used to treat
Movement disorders
What type of receptor is used to transmit VEGF
Tyrosine kinase
What is orphenadrine used to treat
Movement disorders
What is the result of result of carbachol
Pupillary constriction
What is hyoscyamine used to treat
Gastrointestinal disorders
Which family of drugs contain pindolol
Beta 1 and 2 blockers
Which drug is used in long term treatment for hypertension
Alpha 2 agonist
What is the effect of phenylephrine administration
Slowed heart rate (baroreflex response)
Increased blood pressure
Mydriasis
Decreased nasal secretion
What is the effect on the level of ENaC and Na/K ATPase with the administration of spironolactone
Decreased expression of ENaC and sodium/potassium pump
What is the result of Prazosin
Anti hypertension drug
Which family of drugs contain cocaine
Inhibition of NE and DA reuptake
Which drug is used for chronic hypotension
Ephedrine
Which family of drugs contain homatropine
Antimuscarinic
What is the property of binding and target for phentolamine
Reversible binding to alpha receptors
What are the overall effects of pilocarpine
Increased salivation
Accommodation of lens
Increase aqueous humor outflow
Meiosis
What is terbutaline used to treat
Prevents premature labor
Which family of drugs contain bethanechol
Direct acting cholinomimetic
Which drug is used in hypertension emergencies
Fenoldopam (dopamine)
Which family of GPCR ligands contains Angiotensin
Peptides/protein
Which family of drugs contain penbutolol
Beta 1 and 2 blockers
What is atropine used to treat
Heart block (increased AV node conduction) (M2 antagonist) Cholinergic poisoning (organophosphates and AChE inhibators) (M1 anatgonist) Opthamalogy (M1)
Which family of drugs contain carbachol
Direct acting cholinomimetics
Patients on Varenicline need to be watched for which symptom
Depression and suicidal thoughts
What can edrophonium be used to test for
Given to see if its AChE inhibator poisoning or myasthenia gravis
What is the use of dobutamine
Short term use in acute heart failure
Which family of drugs contain Donapezil
Cholinesterase Inhibators
What drug is used in induction of mydriasis for eye examination
Phenylephrine (alpha 1 agonist)
Which family of GPCR ligands contains serotonin
Biogenic amines
Which eye related disorder is contraindicated with muscarinic antagonists
Glaucoma
What is physostigmine used to treat
Atropine overdose
What type of receptor is used to transmit growth hormone (somatostatin)
JAKSTAT
Which family of drugs contain methylphenidate
Increased DA and NE release, decreased reuptake
Which family of drugs contain Neostigmine
Cholinesterase Inhibitors
What is tiotropium used to treat
Respiratory disorders such as asthma and COPD (M3 antagonist)
Which family of drugs contain Endrophonium
Cholinesterase Inhibitors
What is the target of verapamil
L type calcium channel
Which family of GPCR ligands contains leukotrienes
Lipids
What is isoproterenol used to treat
Asthma and respiratory distress
Which family of drugs contain varenicline
Direct acting cholinomimetics
Which family of drugs contain albuterol
Beta agonist
Which family of drugs contain guanethidine
NE release inhibator
What is the drug given fro stress urinary incontinence
Ephedrine
What is the result of using spironolactone
Increase loss of salt and water, leading to decrease in blood volume and BP
What is glycopyrrolate used to treat
Gastrointestinal disorders
Which family of drugs contain biperiden
Antimuscarinic
What is the location of target receptor for mineralcorticoid receptors
Nuclear mineralcorticoid receptors
What is the result of verapamil
- Decreased arythmias
- decreased oxygen use and chest pain
- Decreased hypertension
- Constipation
Which family of drugs contain phenoxybenzamine
Non selective receptor antagonist
What is phentolamine used to treat
Cocaine toxicity
HTN crisis
Pheochromocytoma
Which family of drugs contain Ambenonium
Cholinesterase Inhibators
What is Donepezil used to treat
Treatment of Alzheimer’s
What is ipratropium used to treat
Respiratory disorders such as asthma and COPD (M3 antagonist)
What is the use of dopamine
Congestive severe heart failure with reduced renal perfusion
Which family of drugs contain Propranolol
Beta 1 and 2 bloackers
Which family of drugs contain amphetamines
INcreased release of DA and NE, Decreased reuptake
What type of receptor is used to transmit Interferons
JAKSTAT
Which family of drugs contain lacetalol
Mixed beta and alpha 1 blocker
What is rivastigmine used to treat
Alzheimer’s disease
What is Benztropine used to treat
Movement disorders such as tremors and rigidity in Parkison’s (M1 antagonist)
What is the location of the receptor for thyroid hormones
Nuclear receptors
What is scopolamine used to treat
Motion sickness (M1 antagonist) Ophthalmology
What is the target for dobutamine
Agonist for Beta 1 adrenergic receptors
What is the location of target receptor for Androgens
Nuclear androgen receptors
What is given for poisoning of organophosphates or other cholinesterase inhibitors
- Atropine (crosses into CNS and affects mAChR)
- Pralidoxime (affects n and mAChR to get rid of flaccid paralysis)
Which drug is used for Hypotensive emergencies
- Norepinephrine
- phenylephrine
Which family of drugs contain metyrosine
Tyorisine hydroxylase inhibator
What is cevimeline used to treat
Dry mouth associated with Sjegren’s
Which family of drugs contain Rivastigmine
Cholinesterase Inhibitors
What is the result of acetylcholinesterate inhibitor toxicity
DUMBBELS
-Flaccid paralysis
Which family of GPCR ligands contains aminoacids
GABA
What is pilocarpine used to treat
Acute angle glaucoma
Dry mouth associated with Sjogren’s
What is Oxybutynin used to treat
Urinary incontanence post surgery (Selective M3 antagonist)
Which family of drugs contain trospium
Antimuscarinic
Which family of GPCR ligands contains Adrenocorticotropin (ACTH)
Proteins/peptides
Which family of drugs contain Mecamylamine
Ganglion blockers
What is Galantamine used to treat
Alzheimer’s disease
Which family of drugs contain Tacrine
Cholinesterase inhibitors
What is trospium used to treat
Bladder incontinence (non selective antagonist)
Which family of GPCR ligands contains dopamine
Biogenic amines
Which family of drugs contain solifenacin
Antimuscarinic
What is the target of etoposide
Inhibits topoisomerase 2
What is cyclopentolate used to treat
Ophthalmology
What type of receptor is used to transmit insulin
Tyrosine kinase
Which family of drugs contain terbutaline
Beta agonist
What is endrophonium used to treat
Transiently used to treat myasthenia gravis
Which family of GPCR ligands contains Adenosine
Nucleotides
Which family of drugs contain cevimeline
Direct acting cholinomimetic
Which family of drugs contain organophosphate
Cholinesterase Inhibitor
Which family of GPCR ligands contains ATP
Nucleotides
Which drugs are given for complete AV block and cardiac arrrest
Epinephrine
Isoproterenol
Which family of drugs contain orphenadrine
Antimuscarinic
Which family of drugs contain metoprolol
Beta 1 blockers
What is the receptor stimulated by carachol
Muscarinic and nicotinic
Which family of GPCR ligands contains bradykinin
Peptides/proteins
Which family of drugs contain gycopyrrolate
Antimuscarinic
What drug is given for a nonpolarizing agent at the NMJ
Neostigmine
Which family of drugs contain benztropine
Antimuscarinic
What was tacrine used to treat
Dementia
Which family of drugs contain phenelzine
Inhibitors of MAO
Which family of drugs contain clonidine
Alpha agonist (alpha 2)
Which family of drugs contain Ipratropium
Antimuscarinic
Which family of drugs contain epinephrine
Alpha and Beta
