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Pharmacology & Drugs > Neuro-Autonomic Drugs > Flashcards

Neuro-Autonomic Drugs Flashcards

1
Q

Which family of drugs contain acebutolol

A

Beta 1 blocker

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2
Q

Does edrophonium cross into the CNS

A

No

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3
Q

What is the location of target receptor for estrogens

A

Nuclear estrogen receptors

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4
Q

What is homatropine used to treat

A

Ophthalmology

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5
Q

What is Trihexyphenidyl used to treat

A

Movement disorders such as tremors and rigidity in Parkinson’s (M1 antagonist)

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6
Q

Which family of drugs contain tiotropium

A

Antimuscarinic

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7
Q

What is procyclidine used to treat

A

Movement disorders

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8
Q

Which family of drugs contain cyclopentolate

A

Antimuscarinic

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9
Q

Which family of drugs contain Acetylcholine

A

Direct acting Cholinomimetics

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10
Q

Which family of drugs contain dicyclomine

A

Antimuscarinic

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11
Q

Which family of GPCR ligands contains histamine

A

Biogenic amines

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12
Q

Which family of GPCR ligands contains prostacyclin

A

Lipids

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13
Q

Which family of drugs contain hyoscyamine

A

Antimuscarinic

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14
Q

What are the side affects of alpha blockers

A

Orthostatic hypotension

Reflex induced tachycardia

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15
Q

Which family of drugs contain dobutamine

A

Beta agonists

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16
Q

What is the target for spiralactone

A

Antagonist for aldosterone receptor

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17
Q

Which family of drugs contain ephedrine

A

Increased release and direct adrenergic receptor agonists

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18
Q

Which family of drugs contain nadolol

A

Beta 1 and 2 blockers

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19
Q

What is the target for succinylcholine

A

Antagonist at NMJ

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20
Q

Which family of GPCR ligands contains opioids

A

Peptides/proteins

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21
Q

What is the result of using etoposide

A

Causes DNA, activation of p53 and apoptosis

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22
Q

What type of receptor is used to transmit Leptin

A

JAKSTAT

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23
Q

What is the target for digoxin

A

Sodium/potassium pump

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24
Q

Which drug is used for cardiogenic shock

A

Dopamine

Dobutamine

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25
Q

What is solifenacin used to treat

A

Urinary disorders (selective M3 antagonist)

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26
Q

Which family of GPCR ligands contains ADP

A

Nucleotides

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27
Q

Which family of drugs contain procyclidine

A

Antimuscarinic

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28
Q

What conditions is bethanechol used to treat

A

Non obstructive GI issues

Non obstructive urinary issues

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29
Q

Which antimuscarinic drug is used for a longer time of action

A

Tiotropium (M3 antagonist)

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30
Q

Which family of drugs contain Trihexyphenidyl

A

Antimuscarinic

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31
Q

What type of receptor is used to transmit erythropoietin

A

JAKSTAT

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32
Q

Which family of drugs contain Physostigmine

A

Cholinesterase inhibitors

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33
Q

What is neostigmine used to treat

A

Myasthenia gravis
Reverse nondepolarizing NMJ agents (curare)
Urinary retention

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34
Q

What is the location of target receptor for progesterone

A

Nuclear progesterone receptors

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35
Q

Which family of drugs contain fesoterodine

A

Antimuscarinic

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36
Q

What is methacholine used for

A

An asthma challenge for pulmonary testing

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37
Q

Which family of drugs contain tolterodine

A

Antimuscarinic

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38
Q

Which family of drugs contain selegiline

A

Inhibators of MAO

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39
Q

What is the location of target receptor for glucocorticoid

A

Nuclear glucocorticoid receptors

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40
Q

What is ritodrine used to treat

A

Premature labor

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41
Q

Which family of drugs contain Atropine

A

Antimuscarinic

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42
Q

Which family of drugs contain isoproterenol

A

Beta agonist

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43
Q

Which family of drugs contain Scopolamine

A

Antimuscarinic

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44
Q

Which family of drugs contain methacholine

A

Direct acting cholinomimetics

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45
Q

Which family of drugs contain fenoldopam

A

Dopamine agonists

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46
Q

What is phyridostimgine used to treat

A

Long term treatment for myasthenia gravis

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47
Q

What is carbachol used to treat

A

Acute angle glaucoma

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48
Q

Which family of GPCR ligands contains norepinephrine

A

Biogenic amines

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49
Q

What is tropicamide used to treat

A

Ophthalmology

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50
Q

Which family of drugs contain penylephrine

A

Alpha antagonist (alpha 1)

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51
Q

Which family of drugs contain tropicamide

A

Antimuscarinic

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52
Q

Which family of drugs contain oxybutynin

A

Antimuscarinic

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53
Q

Which family of GPCR ligands contains Thromboxane A2

A

Lipids

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54
Q

What is the overall result of bethanechol

A

Increased secretion of gut and urinary tract

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55
Q

What type of receptor is used to transmit NGF

A

Tyrosine kinase

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56
Q

Which family of drugs contain darifenacin

A

Antimuscarinic

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57
Q

What is Dicyclomine used to treat

A

Gastrointestinal disorders

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58
Q

What type of receptor is used to transmit PDGF

A

Tyrosine kinase

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59
Q

Which family of drugs contain pilocarpine

A

Direct acting cholinomimetics

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60
Q

What class of drug is given for prevention of premature labor

A

Beta 2 agonist

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61
Q

What is varenicline used to treat

A

Cessation of smoking

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62
Q

Which family of drugs contain Pyridostigmine

A

Cholinesterase Inhibators

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63
Q

Which family of drugs contain norepinephrine

A

Alpha and Beta agonists

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64
Q

What type of receptor is used to transmit IGF-1

A

Tyrosine Kinase

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65
Q

Which family of GPCR ligands contains Epinephrine

A

Biogenic amines

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66
Q

Which class of drug is given for glaucoma

A

Alpha 2 agonist

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67
Q

What type of receptor is used to transmit EGF

A

Tyrosine kinase

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68
Q

What is phenylephrine used to treat

A

-nasal congestion
-ophthalmology
-

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69
Q

Which family of drugs contain Echothiophate

A

Cholinesterase Inhibitors

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70
Q

What is dobutamine used to treat

A

Beta 1 > beta 2

Increased heart rate, contractility, CO

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71
Q

What are the treatments for bronchial asthma

A

Beta-2 agonists
Albuterol
Terbutaline

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72
Q

What is tolterodine used to treat

A

Adult urinary incontinence (M2 antagonist)

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73
Q

Which family of drugs contain atenolol

A

Beta 1 blockers

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74
Q

What type of receptor is used to transmit interleukin 2-10,15

A

JAKSTAT

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75
Q

Which family of drugs contain betaxolol

A

Beta 1 blockers

76
Q

Which family of drugs contain Pralidoxime

A

Cholinesterase regenerator

77
Q

What is the mechanism of action of Prazosin

A

Alpha 1 Adrenergic receptor antagonist

78
Q

Which drug should not be given for a depolarizing NMJ blocking agent

A

Acetylcholine esterase inhibitor

79
Q

What type of drug class is propranolol

A

Beta blocker

80
Q

What is the property of binding and target for phenoxybenzamine

A

Irreversible binding to alpha receptors

81
Q

Which family of drugs contain phentolamine

A

Nonselective alpha 1 and 2 antagonist

82
Q

Which family of GPCR ligands contains Acetylcholine

A

Biogenic amines

83
Q

Which family of drugs contain Galantamine

A

Cholinesterase Inhibators

84
Q

Which family of GPCR ligands contains Glutamate

A

Aminoacids

85
Q

What is biperiden used to treat

A

Movement disorders

86
Q

What type of receptor is used to transmit VEGF

A

Tyrosine kinase

87
Q

What is orphenadrine used to treat

A

Movement disorders

88
Q

What is the result of result of carbachol

A

Pupillary constriction

89
Q

What is hyoscyamine used to treat

A

Gastrointestinal disorders

90
Q

Which family of drugs contain pindolol

A

Beta 1 and 2 blockers

91
Q

Which drug is used in long term treatment for hypertension

A

Alpha 2 agonist

92
Q

What is the effect of phenylephrine administration

A

Slowed heart rate (baroreflex response)
Increased blood pressure
Mydriasis
Decreased nasal secretion

93
Q

What is the effect on the level of ENaC and Na/K ATPase with the administration of spironolactone

A

Decreased expression of ENaC and sodium/potassium pump

94
Q

What is the result of Prazosin

A

Anti hypertension drug

95
Q

Which family of drugs contain cocaine

A

Inhibition of NE and DA reuptake

96
Q

Which drug is used for chronic hypotension

A

Ephedrine

97
Q

Which family of drugs contain homatropine

A

Antimuscarinic

98
Q

What is the property of binding and target for phentolamine

A

Reversible binding to alpha receptors

99
Q

What are the overall effects of pilocarpine

A

Increased salivation
Accommodation of lens
Increase aqueous humor outflow
Meiosis

100
Q

What is terbutaline used to treat

A

Prevents premature labor

101
Q

Which family of drugs contain bethanechol

A

Direct acting cholinomimetic

102
Q

Which drug is used in hypertension emergencies

A

Fenoldopam (dopamine)

103
Q

Which family of GPCR ligands contains Angiotensin

A

Peptides/protein

104
Q

Which family of drugs contain penbutolol

A

Beta 1 and 2 blockers

105
Q

What is atropine used to treat

A 
Heart block (increased AV node conduction) (M2 antagonist)
Cholinergic poisoning (organophosphates and AChE inhibators) (M1 anatgonist)
Opthamalogy (M1)
106
Q

Which family of drugs contain carbachol

A

Direct acting cholinomimetics

107
Q

Patients on Varenicline need to be watched for which symptom

A

Depression and suicidal thoughts

108
Q

What can edrophonium be used to test for

A

Given to see if its AChE inhibator poisoning or myasthenia gravis

109
Q

What is the use of dobutamine

A

Short term use in acute heart failure

110
Q

Which family of drugs contain Donapezil

A

Cholinesterase Inhibators

111
Q

What drug is used in induction of mydriasis for eye examination

A

Phenylephrine (alpha 1 agonist)

112
Q

Which family of GPCR ligands contains serotonin

A

Biogenic amines

113
Q

Which eye related disorder is contraindicated with muscarinic antagonists

A

Glaucoma

114
Q

What is physostigmine used to treat

A

Atropine overdose

115
Q

What type of receptor is used to transmit growth hormone (somatostatin)

A

JAKSTAT

116
Q

Which family of drugs contain methylphenidate

A

Increased DA and NE release, decreased reuptake

117
Q

Which family of drugs contain Neostigmine

A

Cholinesterase Inhibitors

118
Q

What is tiotropium used to treat

A

Respiratory disorders such as asthma and COPD (M3 antagonist)

119
Q

Which family of drugs contain Endrophonium

A

Cholinesterase Inhibitors

120
Q

What is the target of verapamil

A

L type calcium channel

121
Q

Which family of GPCR ligands contains leukotrienes

A

Lipids

122
Q

What is isoproterenol used to treat

A

Asthma and respiratory distress

123
Q

Which family of drugs contain varenicline

A

Direct acting cholinomimetics

124
Q

Which family of drugs contain albuterol

A

Beta agonist

125
Q

Which family of drugs contain guanethidine

A

NE release inhibator

126
Q

What is the drug given fro stress urinary incontinence

A

Ephedrine

127
Q

What is the result of using spironolactone

A

Increase loss of salt and water, leading to decrease in blood volume and BP

128
Q

What is glycopyrrolate used to treat

A

Gastrointestinal disorders

129
Q

Which family of drugs contain biperiden

A

Antimuscarinic

130
Q

What is the location of target receptor for mineralcorticoid receptors

A

Nuclear mineralcorticoid receptors

131
Q

What is the result of verapamil

A
  • Decreased arythmias
  • decreased oxygen use and chest pain
  • Decreased hypertension
  • Constipation
132
Q

Which family of drugs contain phenoxybenzamine

A

Non selective receptor antagonist

133
Q

What is phentolamine used to treat

A

Cocaine toxicity
HTN crisis
Pheochromocytoma

134
Q

Which family of drugs contain Ambenonium

A

Cholinesterase Inhibators

135
Q

What is Donepezil used to treat

A

Treatment of Alzheimer’s

136
Q

What is ipratropium used to treat

A

Respiratory disorders such as asthma and COPD (M3 antagonist)

137
Q

What is the use of dopamine

A

Congestive severe heart failure with reduced renal perfusion

138
Q

Which family of drugs contain Propranolol

A

Beta 1 and 2 bloackers

139
Q

Which family of drugs contain amphetamines

A

INcreased release of DA and NE, Decreased reuptake

140
Q

What type of receptor is used to transmit Interferons

A

JAKSTAT

141
Q

Which family of drugs contain lacetalol

A

Mixed beta and alpha 1 blocker

142
Q

What is rivastigmine used to treat

A

Alzheimer’s disease

143
Q

What is Benztropine used to treat

A

Movement disorders such as tremors and rigidity in Parkison’s (M1 antagonist)

144
Q

What is the location of the receptor for thyroid hormones

A

Nuclear receptors

145
Q

What is scopolamine used to treat

A 
Motion sickness (M1 antagonist)
Ophthalmology
146
Q

What is the target for dobutamine

A

Agonist for Beta 1 adrenergic receptors

147
Q

What is the location of target receptor for Androgens

A

Nuclear androgen receptors

148
Q

What is given for poisoning of organophosphates or other cholinesterase inhibitors

A
  • Atropine (crosses into CNS and affects mAChR)

- Pralidoxime (affects n and mAChR to get rid of flaccid paralysis)

149
Q

Which drug is used for Hypotensive emergencies

A
  • Norepinephrine

- phenylephrine

150
Q

Which family of drugs contain metyrosine

A

Tyorisine hydroxylase inhibator

151
Q

What is cevimeline used to treat

A

Dry mouth associated with Sjegren’s

152
Q

Which family of drugs contain Rivastigmine

A

Cholinesterase Inhibitors

153
Q

What is the result of acetylcholinesterate inhibitor toxicity

A

DUMBBELS

-Flaccid paralysis

154
Q

Which family of GPCR ligands contains aminoacids

A

GABA

155
Q

What is pilocarpine used to treat

A

Acute angle glaucoma

Dry mouth associated with Sjogren’s

156
Q

What is Oxybutynin used to treat

A

Urinary incontanence post surgery (Selective M3 antagonist)

157
Q

Which family of drugs contain trospium

A

Antimuscarinic

158
Q

Which family of GPCR ligands contains Adrenocorticotropin (ACTH)

A

Proteins/peptides

159
Q

Which family of drugs contain Mecamylamine

A

Ganglion blockers

160
Q

What is Galantamine used to treat

A

Alzheimer’s disease

161
Q

Which family of drugs contain Tacrine

A

Cholinesterase inhibitors

162
Q

What is trospium used to treat

A

Bladder incontinence (non selective antagonist)

163
Q

Which family of GPCR ligands contains dopamine

A

Biogenic amines

164
Q

Which family of drugs contain solifenacin

A

Antimuscarinic

165
Q

What is the target of etoposide

A

Inhibits topoisomerase 2

166
Q

What is cyclopentolate used to treat

A

Ophthalmology

167
Q

What type of receptor is used to transmit insulin

A

Tyrosine kinase

168
Q

Which family of drugs contain terbutaline

A

Beta agonist

169
Q

What is endrophonium used to treat

A

Transiently used to treat myasthenia gravis

170
Q

Which family of GPCR ligands contains Adenosine

A

Nucleotides

171
Q

Which family of drugs contain cevimeline

A

Direct acting cholinomimetic

172
Q

Which family of drugs contain organophosphate

A

Cholinesterase Inhibitor

173
Q

Which family of GPCR ligands contains ATP

A

Nucleotides

174
Q

Which drugs are given for complete AV block and cardiac arrrest

A

Epinephrine

Isoproterenol

175
Q

Which family of drugs contain orphenadrine

A

Antimuscarinic

176
Q

Which family of drugs contain metoprolol

A

Beta 1 blockers

177
Q

What is the receptor stimulated by carachol

A

Muscarinic and nicotinic

178
Q

Which family of GPCR ligands contains bradykinin

A

Peptides/proteins

179
Q

Which family of drugs contain gycopyrrolate

A

Antimuscarinic

180
Q

What drug is given for a nonpolarizing agent at the NMJ

A

Neostigmine

181
Q

Which family of drugs contain benztropine

A

Antimuscarinic

182
Q

What was tacrine used to treat

A

Dementia

183
Q

Which family of drugs contain phenelzine

A

Inhibitors of MAO

184
Q

Which family of drugs contain clonidine

A

Alpha agonist (alpha 2)

185
Q

Which family of drugs contain Ipratropium

A

Antimuscarinic

186
Q

Which family of drugs contain epinephrine

A

Alpha and Beta

Pharmacology & Drugs (43 decks)

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