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Pharmacology & Drugs > Neuro-Narcotic Analgesics > Flashcards

Neuro-Narcotic Analgesics Flashcards

1
Q

What is the classification for the opioid oxymorphone

A

Semisynthetic full agonist

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2
Q

What are some of the acute affects of opioid use

A

-Respiratory depression, urticaria (skin rash), pruritus (urge to scratch), myoclonus and seizures

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3
Q

What is the classification for the opioid buprenorphine

A

Partial mu-R agonist

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4
Q

What are effects of long term chronic opioid use

A

Hypogonadism, immunosupression, increased feeding and GH secretion, hyperalgesia

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5
Q

What is the only opiod with a low efficacy

A

Codeine

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6
Q

What are the general trends seen in administration of opioids in the altered physiological state of infants

A

Prolonged effect (immature renal function and decreased conjugating ability)

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7
Q

What are the general trends seen in administration of opioids in the altered physiological state of obesity

A

Overdosage (Vd is not represented by the body weight)

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8
Q

What is the mechansim of action for Tapentadol

A

NET inhibator and moderate Mu-R agonist

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9
Q

What are the general trends seen in administration of opioids in the altered physiological state of renal failure

A 
Morphine toxicity (accumulation of M6P)
Pethidine toxicity (accumulation of norpethidine)
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10
Q

What is the classification for the opioid hydromorphone

A

Semisynthetic full agonist

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11
Q

What is the mechanism of action for post synaptic mu receptors

A

Increases potassium efflux and subsequent hyperpolarization

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12
Q

What is nalmefene used to treat

A

Alcohol addiction by antagonist of Mu-R and partial agonist of Kappa

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13
Q

What is the classification for the opioid codeine

A

Natural full agonist

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14
Q

What is the classification for the opioid alfentanil

A

Synthetic full agonist

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15
Q

Which opioids can be used as an antitissive

A
  • Codeine
  • Dextropethorphan
  • Levopropoxyphene
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16
Q

What is the mechanism of tramadol

A

Strong SERT inhibitor, weak NET inhibitor

17
Q

What is the classification for the opioid pethidine

A

Synthetic full agonist

18
Q

What are the general trends seen in administration of opioids in the altered physiological state of hepatic failure.

A

Increased sensitivity (altered BBB if with encephalopathy, along with increased half life due to decreased detoxifying ability

19
Q

What are the 4 opioid mixed receptor agonist antagonists

A
  • Pentazocine
  • Nalbuphine
  • Buprenorphine
  • Butorphanol
20
Q

What is the classification for the opioid methadone

A

Synthetic full agonist

21
Q

What are the contraindications for used of opioids

A
  • Respiratory depression
  • Renal Failure
  • biliary colic
  • blood toxicity
  • Raised intracranial pressure
22
Q

What is the classification for the opioid fentanyl

A

Synthetic full agonist

23
Q

What is the classification for the opioid Morphine

A

Natural full agonist

24
Q

What is methadone used to treat and what is the mechanism

A

Opioid addictions via agonist of Mu-R

25
Q

What are the MOA for Buprenorphine

A

Partial mu agonist and kappa antagonist

26
Q

What is the MOA for Nalbuphine

A

Kappa agonist and mu antagonist

27
Q

What is the classification for the opioid tramadol

A

Synthetic full agonist

28
Q

Which of the opioids are influenced by the first pass system

A
  • Morphine
  • Methadone
  • Fentanyl
29
Q

What are the medium strength opioids

A
  • Nalbuphine
  • Pentazocine
  • Buprenorphine
30
Q

What is the classification for the opioid remifentanil

A

Synthetic full agonist

31
Q

What are the general trends seen in administration of opioids in the altered physiological state of elderly

A

INcreaed sensitivity and prolonged effect (increase fat mass and detoxifying ability)

32
Q

What is the mechanism of action for opioids in the Presynaptic mu receptor

A

Inhibits calcium influx and decreased NT release

33
Q

What is naltrexone used to treat

A

Alcohol and opioid addiction via antagonist of Mu-R and partial agonist of kappa

34
Q

What is the classification for the opioid pentazocine

A

Agonist-antagonist

35
Q

What is the classification for the opioid Naltrexone

A

Mu-R antagonist

36
Q

What is buprenorphine used to treat

A

Opioid addiction via partial agonist of all three receptors

Pharmacology & Drugs (43 decks)

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