Cardio - Heart Failure Flashcards
1
Q
What is the qualification for left ventricular reduced EF
A
LVEF < 50%
2
Q
Systolic failure results in which changes
A
- Loss of inotropy (Decreased ESPVR slope) (Decreased SV and EF
- Ventricular remodeling and dilation (Increased ESV and EDV)
3
Q
What does the pressure volume curve look like in systolic failure
A
Moves to the right
4
Q
What are the changes seen in diastolic failure
A
Decreased compliance:
- Increased EDPVR slope
- Increased ED pressure
- Decreased EDV
5
Q
What does the pressure pressure volume curve look like in diastolic failure
A
Moved to the left
6
Q
What is the resulting EDV following an MI
A
Increased in the LVEDV
7
Q
What is the metabolism of captopril
A
Substrate for CYP2D6
8
Q
What is the substrate for losartan
A
CYP 2C9 and 3A4
9
Q
What is the relation of aldosterone to damage heart vasculature
A
Damaged heart vasculature produces aldosterone after an MI, and induced fibrosis
