Gi-Nausea And Vomiting Flashcards
What adverse effects are common with histamine antagonists
Central anticholinergic properties
What are the drugs for vertigo
Meclizine or
Cyclizine
What are the drugs used to treat diabetic gastroparesis
Metroclopramide
What class of antiemetic agents are 5HT antagonists
Strong
What drug class is Dimenhydrinate
Histamine antagonist
What class of drug is Nabilone
Class 2 cannabinoid
What are some side effects of domamine antagonists
Anticholinergic side effects
What drug class is aprepitant
Neurokinin Antagonist
What drug class is dronabinol
Cannabinoid
What are the general pharmakenetics of 5HT antagonists and what are the exceptions
Short half life, except for:
- Palonosetron
- Granisetron
What is alosetron used to treat
IBS-D
What drug class is Diphenhydramine
Histamine antagonist
What drug class is perphanazine
Dopamine antagonist
What is the drug combination for medium emetogenic regimin
5HT antagonist
Corticosteroid
What drug class is Palonosetron
5 HT antagonist
What is the combination therapy for high emtogenic regimen
- Neurokinin receptor antagonist
- 5HT antagonist
- Corticosteroid
What is the level of antimumetics are cannabinoid
Strong
What drug class is metoclorpradine
Dopamine antagonist (only one not a phenothiazine)
What are the complications of serotonin antagonists
Serotonin syndrome
- Prolonged QT
- Torsade’s
What level of anti-emetics are dopamine antagonists
Weak to moderate
What is the mechanism of action of the neurokinin antagonists
Blockage of receptors in the CTZ/VC
What is the treatment as a prophylaxis of post operative N/V (PONV)
Aprepitant (3 Hours before administration of anesthesia)
What are the therapy uses for neurokinin antagonists
Chemotherapy induced N/V (CINV)
What are the side effects of scopolamine
Significant anticholinergic properties
What drug class is cyclizine
Histamine antagonist
What drug class is granisetron
5HT antagonist
What level of Anti-emetic agent is Neurokinin antagonists
Moderate
What is the use for cyclizine
Motion sickness/vertigo only
What drug class is Fosnetupitant
Neurokinin antagonists
What drug class is scopolamine
M1 antagonist
What level of Anti-emetic are histamine antagonists
Weak
What are the drugs for motion sickness
- Scopolamine
- Dimenhydrinate
- Meclizine
What drug class is nabilone
Cannabinoid agonist
What class of drug is dronabinol
Class 3 cannabinoid
What drug class is hydroxyzine
Histamine antagonist
What drug class is netupitant
Neurokinin antagonist
What is usually the effective combination therapy with neurokinin antagonists
Glucocorticoidsteroid
What drug class is meclizine
Histamine antagonist
What is the low emetogenic regimen
- Corticosteroid or
- 5HT antagonists or
- Metoclopramie or
- prochloroperazine
What drug class is promethazine
Histamine antagonist
What drug class is Fosaprepitant
Neurokinin antagonist
What drug class is chloropromazine
Dopamine antagonist
What is the use for meclizine
Motion sickness/vertigo only
What drug class is phenothiazine’s
Dopamine antagonist
Which of 5HT antagonists has the highest risks
Dolasetron
What is scopolamine used to treat
Motion sickness (path worn for 72 hours)
Which interactions must be monitored with cannabinoids
CNS depressants
CV drugs
Sympathomimetics
What drug class is dolasetron
5HT receptor antagonist
What histamine antagonists are for motion sickness/vertigo
Meclizine
Cyclizine
What are the therapeutic uses
Chemotherapy N/V (CINV)
Radiation induced N/V (RINV)
Post operative N/V (PONV)
NV or Pregnacny (NVP)
What drug class is Ondansetron
5HT antagonist
What drug class is prochloroperazine
Dopamine antagonist
What is a side effect of metoclopramide, but can also be used as a treatment
Stimulate the ACh action in the GI, leading to increased motility in the GI
Which histamine receptor antagonist is given to pregnant patients
Doxylamine with pyridoxine (B6)
What drug class is rolapitant
Neurokinin Antagonist
