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Pharmacology & Drugs > Gi-Nausea And Vomiting > Flashcards

Gi-Nausea And Vomiting Flashcards

1
Q

What adverse effects are common with histamine antagonists

A

Central anticholinergic properties

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2
Q

What are the drugs for vertigo

A

Meclizine or

Cyclizine

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3
Q

What are the drugs used to treat diabetic gastroparesis

A

Metroclopramide

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4
Q

What class of antiemetic agents are 5HT antagonists

A

Strong

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5
Q

What drug class is Dimenhydrinate

A

Histamine antagonist

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6
Q

What class of drug is Nabilone

A

Class 2 cannabinoid

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7
Q

What are some side effects of domamine antagonists

A

Anticholinergic side effects

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8
Q

What drug class is aprepitant

A

Neurokinin Antagonist

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9
Q

What drug class is dronabinol

A

Cannabinoid

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10
Q

What are the general pharmakenetics of 5HT antagonists and what are the exceptions

A

Short half life, except for:

  • Palonosetron
  • Granisetron
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11
Q

What is alosetron used to treat

A

IBS-D

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12
Q

What drug class is Diphenhydramine

A

Histamine antagonist

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13
Q

What drug class is perphanazine

A

Dopamine antagonist

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14
Q

What is the drug combination for medium emetogenic regimin

A

5HT antagonist

Corticosteroid

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15
Q

What drug class is Palonosetron

A

5 HT antagonist

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16
Q

What is the combination therapy for high emtogenic regimen

A
  • Neurokinin receptor antagonist
  • 5HT antagonist
  • Corticosteroid
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17
Q

What is the level of antimumetics are cannabinoid

A

Strong

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18
Q

What drug class is metoclorpradine

A

Dopamine antagonist (only one not a phenothiazine)

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19
Q

What are the complications of serotonin antagonists

A

Serotonin syndrome

  • Prolonged QT
  • Torsade’s
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20
Q

What level of anti-emetics are dopamine antagonists

A

Weak to moderate

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21
Q

What is the mechanism of action of the neurokinin antagonists

A

Blockage of receptors in the CTZ/VC

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22
Q

What is the treatment as a prophylaxis of post operative N/V (PONV)

A

Aprepitant (3 Hours before administration of anesthesia)

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23
Q

What are the therapy uses for neurokinin antagonists

A

Chemotherapy induced N/V (CINV)

24
Q

What are the side effects of scopolamine

A

Significant anticholinergic properties

25
Q

What drug class is cyclizine

A

Histamine antagonist

26
Q

What drug class is granisetron

A

5HT antagonist

27
Q

What level of Anti-emetic agent is Neurokinin antagonists

A

Moderate

28
Q

What is the use for cyclizine

A

Motion sickness/vertigo only

29
Q

What drug class is Fosnetupitant

A

Neurokinin antagonists

30
Q

What drug class is scopolamine

A

M1 antagonist

31
Q

What level of Anti-emetic are histamine antagonists

A

Weak

32
Q

What are the drugs for motion sickness

A
  • Scopolamine
  • Dimenhydrinate
  • Meclizine
33
Q

What drug class is nabilone

A

Cannabinoid agonist

34
Q

What class of drug is dronabinol

A

Class 3 cannabinoid

35
Q

What drug class is hydroxyzine

A

Histamine antagonist

36
Q

What drug class is netupitant

A

Neurokinin antagonist

37
Q

What is usually the effective combination therapy with neurokinin antagonists

A

Glucocorticoidsteroid

38
Q

What drug class is meclizine

A

Histamine antagonist

39
Q

What is the low emetogenic regimen

A
  • Corticosteroid or
  • 5HT antagonists or
  • Metoclopramie or
  • prochloroperazine
40
Q

What drug class is promethazine

A

Histamine antagonist

41
Q

What drug class is Fosaprepitant

A

Neurokinin antagonist

42
Q

What drug class is chloropromazine

A

Dopamine antagonist

43
Q

What is the use for meclizine

A

Motion sickness/vertigo only

44
Q

What drug class is phenothiazine’s

A

Dopamine antagonist

45
Q

Which of 5HT antagonists has the highest risks

A

Dolasetron

46
Q

What is scopolamine used to treat

A

Motion sickness (path worn for 72 hours)

47
Q

Which interactions must be monitored with cannabinoids

A

CNS depressants
CV drugs
Sympathomimetics

48
Q

What drug class is dolasetron

A

5HT receptor antagonist

49
Q

What histamine antagonists are for motion sickness/vertigo

A

Meclizine

Cyclizine

50
Q

What are the therapeutic uses

A

Chemotherapy N/V (CINV)
Radiation induced N/V (RINV)
Post operative N/V (PONV)
NV or Pregnacny (NVP)

51
Q

What drug class is Ondansetron

A

5HT antagonist

52
Q

What drug class is prochloroperazine

A

Dopamine antagonist

53
Q

What is a side effect of metoclopramide, but can also be used as a treatment

A

Stimulate the ACh action in the GI, leading to increased motility in the GI

54
Q

Which histamine receptor antagonist is given to pregnant patients

A

Doxylamine with pyridoxine (B6)

55
Q

What drug class is rolapitant

A

Neurokinin Antagonist

Pharmacology & Drugs (43 decks)

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