GI-Diarrhea And Abdominal Pain Flashcards
What drug class is diphenoxylate
Opioid agonists
What is a severe side effect of alosetron and what is the sign that it may occur
Ischemic colitis is a severe complication, and is indicated by a patient developing constipation (especially since the drug was given to a pt with diarrhea)
What drug class is lubiprostone
Selective chloride channel activator
What drug class is bisacodyl
Stimulant laxitive
What drug class is crofelemer
Chloride channel inhibitors
What conditions are treated with lubiprostone
- IBS-C
- chronic idiopathic constipation (CIC)
- Opioid induced constipation (OIC)
What is castor oil hydrolized to
Ricinoleic acid
What drug class is alosetron
5 HT antagonists
What drug class is naloxegol
Opioid antagonist
What is the mechanism of action for guanylate cyclase G agonist
Increases cGMP leading so secretion of chloride and bicarbonate
Which patients need extra monitoring when on eluxadoline
Those without gallbladders at risk for pancreatitis
What drug class is glycerin
Stimulant laxitve
What drug class is dicylomine
Antimuscarinic
What drug class is chlordiazepoxide
Antimuscarinic
What is guanylate cyclase C agonists used to treat
Constipation
What is the drug class opioid agonists used to treat
Diarrhea
Which conditions are treated with Linaclotide
IBS- constipation
Chronic idiopathic constipation
What is the drug class 5HT antagonists used to treat
Diarrhea
What drug class is alvimopan
Opioid antagonists
What drug class is hyoscyamine
Antimuscarinic
What is the indication for eluxadoline
IBS-diarrheal subtype (IBS-D)
What drug class is methylnaltrexone
Opioid antagonist
What drug class is senna
Stimulant laxitive
What drug class is loperamide
Opioid agonists
What is the source of crofelemer
Sap from croton lechleri
What is sodium picosulfate used for
Precolonoscopy
What is the drug class prostaglandin inhibators used to treat
Diarrhea
What is the mechanism of action of stimulants
Aka irritants and actually aggregate the lining to increase motility
What drug class is Eluxadoine
Opioid agonists
What is the complication seen with alvimopan
Risk of MI
What are the contraindications for eluxadoline
- Biliary tract infection and bile issues
- Panceratic issues
- liver failure
- alcoholism
What are selective Chloride channel activators used to treat
Constipation
What drug class is castor oil
Stimulant laxitive
What are the side effects of treatment of antimuscarinic in IBS patients
Anticholinergic effects (DUMBBELLS)
What drug class is bismuth
Prostaglandin inhibators
What is the drug class chloride channel inhibitors used to treat
Diarrhea
When is alosetron used
Chronic sever, IBS-diarrheal is not responsive to other therapies (especially in women)
What drug class is clidinium
Antimuscarinic
What is the mechanism of action for lubiprostone
Increases the secretion by activating chloride channels CIC-2 in luminal epithelium
Which patients are given crofelemer
Non-infectious Diarrhea in HIV and AIDs patients with anti-retroviral therapy
When is Alvimopan used
Accelerating time in GI recovery following bowel surgery and prevention of ileus
What are the antimuscarinic agents given for
Abdominal pain/IBS
What drug class is linaclotide
Guanylate Cyclase C agonists
What must be given with diphenooxylate and what is the reasoning
Class 5 drug opiate, given with atropine for abuse potential
What drug class is calcium polycarbophil
Bulk forming cathartic
