Renal- Male GU Pharm Flashcards
What is the result of using alprostadil
Prostaglandin E1 that is injected into the penis
What class of drug is avanafil
PDE-5 Inhibitor
What is the specificity for alfuzosin
Non selective alpha 1
What is the specificity for silodosin
Alpha1A = Alpha1D >alpha 1 B
What class of drug is dutasteride
Steroid 5alpha reductase inhibitor
What are the adverse effects of terazosin
Postural hypotension, dizziness, fatigue
Which class of drug is doxazosin
Alpha 1 adrenergic receptor antagonist
What is the function of PDE-5
Decreases the amount of cAMP, which increases the amount of calcium and smooth muscle contraction, resulting in less of an erection
Which class of drug is alfuzosin
Alpha 1 adrenergic receptor antagonist
What is the fastest acting PDE-5 inhibitors
Avanafil
What is the time period of treatment for dutasteride
3-6 months
What class of drug is vardenafil
PDE-5 Inhibitor
What class of drug is tadalafil
PDE-5 inhibitor
Which class of drug is silodosin
Alpha 1 adrenergic receptor antagonist
Which class of drug is terazsin
Alpha 1 adrenergic receptor antagonist
What are the drug interactions for alfuzosin
PDE 5 inhibitors (Sildenafil, vardenafil)
Increased CYP3A4 substrates
What is the target for finasteride
Specific inhibitor of SAR2, which is a steroid 5 alpha reductase
What class of drug is tadalafil
PDE-5 Inhibitor
What is the uroselectivity of terazosin
None
What are the contraindications specific for sildenafil
Concurrent alpha blockers initiated at lowest recommended dose
What are the drug interactions of tamsulosin
PDE 5 inhibitors (Sildenafil, vardenafil)
Increased CYP3A4 substrates
What class of drug is sildenafil
PDE-5 Inhibitor
What conditions are tadalafil used for
BPH and ED
What is the time period for treatment in finasteride
3-6 months
What are the drug interactions for silodosin
PDE 5 inhibitors (Sildenafil, vardenafil)
Increased CYP3A4 substrates
Which patient conditions should be avoided with alfuzosin
Avoid hepatic impairment
What is the mechanism of action for alprostadil
-Acts lie PGE1, which increases the activity of adenylate cyclase. This will increases the amount of cAMP, decrease the amount of calcium, and increases the amount of muscle relaxation that results in erection
What are the adverse effects specific to tadalifil
Back pain, myalgia, limb pain
What is the location of SAR 1 and 2
SAR1 - serum
SAR2- Prostate
What class of drug is finasteride
Steroid 5 alpha reductase inhibitor
What is the result when the GU system is antagonized with alpha 1 antagonists
-Reduces spasms, promotes muscle relaxation and improved urine flow
What is the specificity for doxazosin
Alpha 1
What are the drug interactions for terazosin
PDE5 inhibitors (sildenafil, vardenafil)
What is the mechanism of action for steroid 5alpha reductase inhibitors
Prevents enlargement and shrinks the prostate by blocking 5 alpha reductase, which converts T to DHT
What is the metabolism mechanism for PDE-5 Inhibitor
CYP3A4
What are the drug interactions for doxazosin
PDE5 inhibitors (sildenafil, vardenafil)
What is the longest lasting PDE-5 Inhibitor
Tadalafil (36 hours)
What are the adverse effects of doxazosin
Postural hypotension, dizziness, fatigue
What is the adverse effects of silodosin
Reduced ejaculation, IFIS
What is the time period for effect with an alpha 1 adrenergic antagonist
Rapid relief of symptoms (days)
What is the overall result of GU system when alpha 1 receptors are agonized by NE
- Muscle contraction and bladder outlet obstruction
- Detrusor instability
What is the adverse effects of tamsulosin
Reduced ejaculation, IFIS
How is avanafil different from the other PDE-5 inhibitors with regards to timing
Can be taken high does 15 minutes before or normal dose 30 minutes before. All the others need an hour
What is the target for dutasteride
Nonspecific inhibitor of SAR 1 and 2, which are steroid alpha 5 reductases
What is the adrenergic receptors in the Spinal cord and what is the function
Alpha 1D, and gives control of urinary function
Which is the drug that will be effective in treating BPH and ED
Tadalafil
Which drug will result in a larger decreased in the amount of serum DHT
Dutasteride (dual inhibitor)
What are the adverse effects of alfuzosin
QT prolongation
What is the uroselectivity of silodosin
Specificity alpha a1A=a1D
What are the contraindications of vardenafil
Needs to be hemodynamically stable
What is the uroselectivity of tamsulosin
Specificity, alpha 1A=alpha AD
What is the adrenergic receptor in the prostate and what is the result
Alpha 1A which causes smooth muscle contraction
What is the overall serum levels as a result of steroid 5 alpha reductase inhibitors
-Decreased DHT
-Decreased PSA
Increased testosterone
Decreased DHT
What are the contraindications for tadalafil
When used for BPH, concurrent alpha 1 blockers not recommended
What is the adrenergic receptor in the detrusor muscle
Alpha 1D > alpha1A
What is the uroselectivity of doxazosin
None
What are the contraindications for PDE-5 Inhibitors
-Organic nitrates, leading to dangerous hypotension
What are the adverse effects of alprostadil
Prolonged erection (priapism) that leads to clogged blood, but can result in fibrosis and ED
What is the specificity for tamsulosin
Alpha1A = Alpha1D >alpha 1 B
Which class of drug is tamsulosin
Alpha 1 adrenergic receptor antagonist
What is the uroselectivity of alfuzosin
Very function and selective, as collects in the urine
What is the drug class of alprostadil
Prostaglandin E1
What is the common clinal side effects seen with PDE-5 Inhibitor
Blue/burred vision due to nonspecific binding to PDE-6
What is the specificity for terazosin
Alpha 1
