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Pharmacology & Drugs > Renal- Male GU Pharm > Flashcards

Renal- Male GU Pharm Flashcards

1
Q

What is the result of using alprostadil

A

Prostaglandin E1 that is injected into the penis

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2
Q

What class of drug is avanafil

A

PDE-5 Inhibitor

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3
Q

What is the specificity for alfuzosin

A

Non selective alpha 1

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4
Q

What is the specificity for silodosin

A

Alpha1A = Alpha1D >alpha 1 B

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5
Q

What class of drug is dutasteride

A

Steroid 5alpha reductase inhibitor

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6
Q

What are the adverse effects of terazosin

A

Postural hypotension, dizziness, fatigue

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7
Q

Which class of drug is doxazosin

A

Alpha 1 adrenergic receptor antagonist

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8
Q

What is the function of PDE-5

A

Decreases the amount of cAMP, which increases the amount of calcium and smooth muscle contraction, resulting in less of an erection

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9
Q

Which class of drug is alfuzosin

A

Alpha 1 adrenergic receptor antagonist

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10
Q

What is the fastest acting PDE-5 inhibitors

A

Avanafil

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11
Q

What is the time period of treatment for dutasteride

A

3-6 months

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12
Q

What class of drug is vardenafil

A

PDE-5 Inhibitor

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13
Q

What class of drug is tadalafil

A

PDE-5 inhibitor

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14
Q

Which class of drug is silodosin

A

Alpha 1 adrenergic receptor antagonist

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15
Q

Which class of drug is terazsin

A

Alpha 1 adrenergic receptor antagonist

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16
Q

What are the drug interactions for alfuzosin

A

PDE 5 inhibitors (Sildenafil, vardenafil)

Increased CYP3A4 substrates

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17
Q

What is the target for finasteride

A

Specific inhibitor of SAR2, which is a steroid 5 alpha reductase

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18
Q

What class of drug is tadalafil

A

PDE-5 Inhibitor

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19
Q

What is the uroselectivity of terazosin

A

None

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20
Q

What are the contraindications specific for sildenafil

A

Concurrent alpha blockers initiated at lowest recommended dose

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21
Q

What are the drug interactions of tamsulosin

A

PDE 5 inhibitors (Sildenafil, vardenafil)

Increased CYP3A4 substrates

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22
Q

What class of drug is sildenafil

A

PDE-5 Inhibitor

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23
Q

What conditions are tadalafil used for

A

BPH and ED

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24
Q

What is the time period for treatment in finasteride

A

3-6 months

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25
Q

What are the drug interactions for silodosin

A

PDE 5 inhibitors (Sildenafil, vardenafil)

Increased CYP3A4 substrates

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26
Q

Which patient conditions should be avoided with alfuzosin

A

Avoid hepatic impairment

27
Q

What is the mechanism of action for alprostadil

A

-Acts lie PGE1, which increases the activity of adenylate cyclase. This will increases the amount of cAMP, decrease the amount of calcium, and increases the amount of muscle relaxation that results in erection

28
Q

What are the adverse effects specific to tadalifil

A

Back pain, myalgia, limb pain

29
Q

What is the location of SAR 1 and 2

A

SAR1 - serum

SAR2- Prostate

30
Q

What class of drug is finasteride

A

Steroid 5 alpha reductase inhibitor

31
Q

What is the result when the GU system is antagonized with alpha 1 antagonists

A

-Reduces spasms, promotes muscle relaxation and improved urine flow

32
Q

What is the specificity for doxazosin

A

Alpha 1

33
Q

What are the drug interactions for terazosin

A

PDE5 inhibitors (sildenafil, vardenafil)

34
Q

What is the mechanism of action for steroid 5alpha reductase inhibitors

A

Prevents enlargement and shrinks the prostate by blocking 5 alpha reductase, which converts T to DHT

35
Q

What is the metabolism mechanism for PDE-5 Inhibitor

A

CYP3A4

36
Q

What are the drug interactions for doxazosin

A

PDE5 inhibitors (sildenafil, vardenafil)

37
Q

What is the longest lasting PDE-5 Inhibitor

A

Tadalafil (36 hours)

38
Q

What are the adverse effects of doxazosin

A

Postural hypotension, dizziness, fatigue

39
Q

What is the adverse effects of silodosin

A

Reduced ejaculation, IFIS

40
Q

What is the time period for effect with an alpha 1 adrenergic antagonist

A

Rapid relief of symptoms (days)

41
Q

What is the overall result of GU system when alpha 1 receptors are agonized by NE

A
  • Muscle contraction and bladder outlet obstruction

- Detrusor instability

42
Q

What is the adverse effects of tamsulosin

A

Reduced ejaculation, IFIS

43
Q

How is avanafil different from the other PDE-5 inhibitors with regards to timing

A

Can be taken high does 15 minutes before or normal dose 30 minutes before. All the others need an hour

44
Q

What is the target for dutasteride

A

Nonspecific inhibitor of SAR 1 and 2, which are steroid alpha 5 reductases

45
Q

What is the adrenergic receptors in the Spinal cord and what is the function

A

Alpha 1D, and gives control of urinary function

46
Q

Which is the drug that will be effective in treating BPH and ED

A

Tadalafil

47
Q

Which drug will result in a larger decreased in the amount of serum DHT

A

Dutasteride (dual inhibitor)

48
Q

What are the adverse effects of alfuzosin

A

QT prolongation

49
Q

What is the uroselectivity of silodosin

A

Specificity alpha a1A=a1D

50
Q

What are the contraindications of vardenafil

A

Needs to be hemodynamically stable

51
Q

What is the uroselectivity of tamsulosin

A

Specificity, alpha 1A=alpha AD

52
Q

What is the adrenergic receptor in the prostate and what is the result

A

Alpha 1A which causes smooth muscle contraction

53
Q

What is the overall serum levels as a result of steroid 5 alpha reductase inhibitors

A

-Decreased DHT
-Decreased PSA
Increased testosterone
Decreased DHT

54
Q

What are the contraindications for tadalafil

A

When used for BPH, concurrent alpha 1 blockers not recommended

55
Q

What is the adrenergic receptor in the detrusor muscle

A

Alpha 1D > alpha1A

56
Q

What is the uroselectivity of doxazosin

A

None

57
Q

What are the contraindications for PDE-5 Inhibitors

A

-Organic nitrates, leading to dangerous hypotension

58
Q

What are the adverse effects of alprostadil

A

Prolonged erection (priapism) that leads to clogged blood, but can result in fibrosis and ED

59
Q

What is the specificity for tamsulosin

A

Alpha1A = Alpha1D >alpha 1 B

60
Q

Which class of drug is tamsulosin

A

Alpha 1 adrenergic receptor antagonist

61
Q

What is the uroselectivity of alfuzosin

A

Very function and selective, as collects in the urine

62
Q

What is the drug class of alprostadil

A

Prostaglandin E1

63
Q

What is the common clinal side effects seen with PDE-5 Inhibitor

A

Blue/burred vision due to nonspecific binding to PDE-6

64
Q

What is the specificity for terazosin

A

Alpha 1

Pharmacology & Drugs (43 decks)

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