Respiratory Drugs-antifungals

Question 1

What is the treatment for Aspergillus

Answer 1

Voriconazole

Question 2

What form is posaconazole available for

Answer 2

Liquid oral

Question 3

Which fungi targeted with intraconazole

Answer 3

Dimorphic such as histo, blasto, sporothrix

Question 4

Adverse effect of ketoconazole

Answer 4

Interacts with human P450

Question 5

What is the permeability if fluconazole into CSF

Answer 5

Good penetration

Question 6

Elimination of azoles are where

Answer 6

All hepatic except fluconazole which is renal

Question 7

Adverse affects of flucytosine

Answer 7

Blood based issues (anemia, leukopenia, thrombocytopenia

Question 8

Site of action for amp B

Answer 8

Membrane function

Question 9

What is the permeability of intraconazole

Answer 9

Poor penetration into CSF

Question 10

Drug for esophageal candidiasis or candidemia

Answer 10

Anidulafungin

Question 11

MOA of echinocandins

Answer 11

Inhibits glucan synthase

Question 12

MOA for flucytosine

Answer 12

Converted to product that inhibits RNA and DNA synthesis

Question 13

What is the treatment for mucormycosis

Answer 13

Posaconazole

Question 14

Site of action for azoles

Answer 14

Ergosterol synthesis

Question 15

What are the adverse effects of voriconazole

Answer 15

Inhibits CYP3A4

Visual disturbances

Question 16

Site of action for echinocandins

Answer 16

Cell wall synthesis

Question 17

Administration form of echinocandins

Answer 17

IV only

Question 18

What is posaconazole used for

Answer 18

• Salvage of invasive aspergillosis
• prophylaxis in chemo for leukemia
• allogenic bone marrow transplants with graft versus host