Neuro-Metronidazole Flashcards
1
Q
What kind of drug is Metronidazole
A
Prodrug
2
Q
How is Mitronidazole and 5-Nitroimidazoles activated
A
Activation by the susceptible anaerobic pathogens
3
Q
What are the targets of mitronidazole and 5-nitromidazoles
A
Anaerobic bacteria and protozoan
4
Q
What is the mechanism of action for mitronidazole and 5-nitroimidazoles
A
An electron from the ETC is loaded onto the drug, which then creates a reactive ion that does DNA damage
5
Q
What is a mechanism of resistance against metronidazole and 5-nitroimidazoles
A
Increased production of O2 (competes with drug)
6
Q
What are the side effects of mitronidazole
A
- Metallic taste in mouth
- Disulfiram effect (vomiting if taken with alcohol)
