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Pharmacology & Drugs > Neuro-Movment Disorder Drugs > Flashcards

Neuro-Movment Disorder Drugs Flashcards

1
Q

Which dopamine receptor is targeted for Pramipexole

A

D3

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2
Q

What class of drug is tolcapone

A

Catechol-O-methyltransferase

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3
Q

What is the origin/nature of amandtadine

A

Antiviral agent

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4
Q

What is zinc sulfate used to treat

A

Wilson disease

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5
Q

What is potassium disulfide used to treat

A

Wilson disease

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6
Q

What class of drug is benztropine

A

Anticholinergic

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7
Q

What class of drug is biperiden

A

Anticholinergic

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8
Q

What class of drug is procyclidine

A

Anticholinergic

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9
Q

What is the mechanism of action for Penicillamine

A

Cheating agent that forms a stable complex with copper and excreted via kidney

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10
Q

During administration of domaine receptor agonists, what side effects are seen in movement changes

A

Choreoathetosis (intermediate speed) of the face and distal extremities

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11
Q

MAO-B is responsible for metabolizing which compounds

A

Phenylethylamine and benzylamine

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12
Q

Where does apomorphine act

A

Dopamine (D2) receptors

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13
Q

What class of drug is entacapone

A

Catechol-O-methyltransferase inhibitor

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14
Q

Antiphycotic drugs can cause which side effects

A

Extrapyramidal syndromes, weight gain, sedation, irritability, and phobias

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15
Q

Which two beta blocking drugs can be given to someone with beta-1 tremors

A
  • Metoprolol

- Propranolol

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16
Q

What are 2 drugs that can be used to treat Huntington disease

A
  • reserpine

- tetrabenazine

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17
Q

Which patient sets is administration of dopamine agonists contraindicated

A
  • psychotic illness
  • MI
  • peptic ulceration
  • peripheral vascular disease
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18
Q

MAO-A is primarily responsible for the metabolism of which compound

A

NE and serotonin

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19
Q

What class of drug is apomorphine

A

Dopamine agonist

20
Q

During administration of domaine receptor agonists, what side effects are seen in the GI

A

Anorexia, nausea, vomiting, constipation

21
Q

What class of drug is selegiline

A

MOA inhibitor

22
Q

What is the mechanism of action for trientine, zinc acetate, and zinc sulfate

A

Chetalating agent which increases the fecal excretion of copper by decreased GI absorption

23
Q

What are treatments for restless leg syndrome

A
  • Resolving iron deficiency

- dopamine agonists

24
Q

What class of drug is pramipexole

A

Dopamine agonist

25
Q

What is penicillamine used to treat

A

Wilson disease

26
Q

What class of drug is ropinirole

A

Dopamine agonist

27
Q

What class of drug is rasagiline

A

MOA inhibitor

28
Q

Which serotonin receptor can be used for tremors

A

Topirimate

29
Q

What class of drug is trihexyphenidyl

A

Anticholinergic

30
Q

Which dopamine receptor is targeted for Bromocriptine

A

D2

31
Q

Which dopamine receptor is targeted for ropinirole

A

D2

32
Q

Clonidine and guanfacine can be used to alternatively treat which condition

A

Tics

33
Q

What is Trientine used to treat

A

Wilson’s disease

34
Q

What is the only drug that is known to increase the survival of ALS

A

Riluzole

35
Q

What part of the body does entacapone affect

A

Peripheral only

36
Q

What is the mechanism of action for potassium disulfide

A

Reduced intestinal absorption of copper

37
Q

What is zinc acetate used to treat

A

Wilson disease

38
Q

What condition can pimozide used to treat

A

Tics

39
Q

What is the mechanism of action of reserpine and tetrabenzazine

A

Impairs dopamine transmission

40
Q

What is the mechanism of action for Riluzole

A

Inhibits glutamate release and activation of sodium channels

41
Q

What part of the body does tolcapone act in

A

Central and peripheral acting

42
Q

During administration of domaine receptor agonists, what side effects are seen in the CV

A

Postural hypotension, digital spasms,peripheral edema and arrhythmias

43
Q

What is the method that Selegiline works

A

Inhibits MAO-B, slowing the breakdown of dopamine

44
Q

What is the method that Rasagiline works

A

Inhibition of MAO-B and works as a neuroprotective agent

45
Q

What class of drug is orphenadrine

A

Anticholinergic

46
Q

Which benzodiazepine can be used for tremors

A

Alprazolam

47
Q

What class of drug is bromocriptine

A

Dopamine agonist

Pharmacology & Drugs (43 decks)

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