Neuro-Movment Disorder Drugs Flashcards
Which dopamine receptor is targeted for Pramipexole
D3
What class of drug is tolcapone
Catechol-O-methyltransferase
What is the origin/nature of amandtadine
Antiviral agent
What is zinc sulfate used to treat
Wilson disease
What is potassium disulfide used to treat
Wilson disease
What class of drug is benztropine
Anticholinergic
What class of drug is biperiden
Anticholinergic
What class of drug is procyclidine
Anticholinergic
What is the mechanism of action for Penicillamine
Cheating agent that forms a stable complex with copper and excreted via kidney
During administration of domaine receptor agonists, what side effects are seen in movement changes
Choreoathetosis (intermediate speed) of the face and distal extremities
MAO-B is responsible for metabolizing which compounds
Phenylethylamine and benzylamine
Where does apomorphine act
Dopamine (D2) receptors
What class of drug is entacapone
Catechol-O-methyltransferase inhibitor
Antiphycotic drugs can cause which side effects
Extrapyramidal syndromes, weight gain, sedation, irritability, and phobias
Which two beta blocking drugs can be given to someone with beta-1 tremors
- Metoprolol
- Propranolol
What are 2 drugs that can be used to treat Huntington disease
- reserpine
- tetrabenazine
Which patient sets is administration of dopamine agonists contraindicated
- psychotic illness
- MI
- peptic ulceration
- peripheral vascular disease
MAO-A is primarily responsible for the metabolism of which compound
NE and serotonin
What class of drug is apomorphine
Dopamine agonist
During administration of domaine receptor agonists, what side effects are seen in the GI
Anorexia, nausea, vomiting, constipation
What class of drug is selegiline
MOA inhibitor
What is the mechanism of action for trientine, zinc acetate, and zinc sulfate
Chetalating agent which increases the fecal excretion of copper by decreased GI absorption
What are treatments for restless leg syndrome
- Resolving iron deficiency
- dopamine agonists
What class of drug is pramipexole
Dopamine agonist
What is penicillamine used to treat
Wilson disease
What class of drug is ropinirole
Dopamine agonist
What class of drug is rasagiline
MOA inhibitor
Which serotonin receptor can be used for tremors
Topirimate
What class of drug is trihexyphenidyl
Anticholinergic
Which dopamine receptor is targeted for Bromocriptine
D2
Which dopamine receptor is targeted for ropinirole
D2
Clonidine and guanfacine can be used to alternatively treat which condition
Tics
What is Trientine used to treat
Wilson’s disease
What is the only drug that is known to increase the survival of ALS
Riluzole
What part of the body does entacapone affect
Peripheral only
What is the mechanism of action for potassium disulfide
Reduced intestinal absorption of copper
What is zinc acetate used to treat
Wilson disease
What condition can pimozide used to treat
Tics
What is the mechanism of action of reserpine and tetrabenzazine
Impairs dopamine transmission
What is the mechanism of action for Riluzole
Inhibits glutamate release and activation of sodium channels
What part of the body does tolcapone act in
Central and peripheral acting
During administration of domaine receptor agonists, what side effects are seen in the CV
Postural hypotension, digital spasms,peripheral edema and arrhythmias
What is the method that Selegiline works
Inhibits MAO-B, slowing the breakdown of dopamine
What is the method that Rasagiline works
Inhibition of MAO-B and works as a neuroprotective agent
What class of drug is orphenadrine
Anticholinergic
Which benzodiazepine can be used for tremors
Alprazolam
What class of drug is bromocriptine
Dopamine agonist
