Resp Viruses Flashcards

1
Q

responsible for summer “cold and flu” resp infections and undifferentiated fevers

A

enteroviruses

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1
Q

___ complications of parainfluenza virus infections common in young,

may progess to ___

A

lower respiratory conplications

Croup

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2
Q

basic clinical features influenza

A

self-limited 3-7 days

secondary bacterial infections cause of death:

strep pneumo

staph a.

haemophilus influenzae

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2
Q

subacure scleorising panencephalits in measels infection

A

CNS - personality

behavior

memory changes

myclonic jerks

spasticity

blindness

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3
Q

(drugs)inhibit uncoating by blocking M2 proteins

A

amantadine

rimantidine

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4
Q

temperature sensitivity rhinovirus

A

grows better at 33 than 37

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4
Q

pharyngocojunctival fever in adenovirus infection

A

red eyes

sore throat

febrile

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5
Q

vaccine adenovirus

A

not for public (type 4 and 7 in works)

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5
Q

virus morphology picorna

A

+RNA non-enveloped

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7
Q

pathogenesis influenza

A

infects ciliated epithial cells

replication destroys resp epithelium

cytotoxic T cell - mediated damage

(viremia does NOT play a major role)

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7
Q

vaccine respiratory syncytial virus

A

natural infection does not prevent re-infection

re-infection especially risky in elderly

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7
Q

emerging resp viruses isolated to bats > pigs > humans in australia and Asia

A

hendra virus

nipah virus

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9
Q

dates and transmission H5N1

A

2003-Junly 2014

does not transmit easily among people

household poultry or contaminated environment

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10
Q

adenovirus disease sequale

A

acute resp disease

pneumonia

pharyngoconjunctival fever

conjunctivitis

GI

hemorrhagic cystitis (bladder inflam)

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11
Q

treatment for respiratory syncytial virus

healthy infant

premature/immunocompromised infant

premature infants

A

healthy - supportive O2, fluids, nebulized cold steam

**premature or immunocomp: **aerosolized ribavirin

**premature infants: **passive immunisation with anti-RSV Ig and humanized monoclonal abx

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11
Q

vaccines metapneumovirus

A

none (or therapies)

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12
Q

virus morphology orthomyxo and paramyxo viruses

A

-RNA,

enveloped

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13
Q

influenza A, B C, virus morphology and family

A

orthomyxoviridae

segmented -RNA

enveloped

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14
Q

atypical measels presentatoin

A

intense rash

vesicles, petechiae, prupura, or urticaria

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15
Q

vaccines Rhinovirus

A

none

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16
Q

antibodies against future influenza infections are specific for

A

epitopes on hemagglutinin

neuraminidase proteins

17
Q

most common cause of death in children with measles

A

pneumonia

19
Q

symptomology MERS-CoV

A

severe pneumonia and renal failure

still birth

nosocomial infections possible

19
Q

post measles encepahlitis

A

headache

confusion

vomitng

coma after rashi disapates

20
Q

metapneumovirus vs RSV

A

RSV milder, severe disease only in infants, elderly, immunocompromised

21
Q

parainfluena virus serotypes most likely to cause Croup

A

Type 1 an d 2

21
Q

infects everyone by age 2

A

respiratoy syncytial virus

22
Q

metapneumovirus ID’d via

A

RT-PCR

23
Q

virus morphology corona virus

A

+RNA

enveloped

25
Q

vaccine Coronavirus SARS

A

none

26
Q

influenza (drugs) inhibit release of progeny influenza virus (neuraminidase inhibitors)

A

Zanamivir

Oseltamivir

27
Q

SARS viral class

A

coronavirus

28
Q

influenza ___ only undergoes minor antigenic changes (drift)

A

B

30
Q

rare complications of influenza

A

myositis and cardiac involvement

guillain Barre

encephalitis

reye syndrome

31
Q

symptoms EV-D68 enterovirus

A

severe resp infection

wheezing (higher risk in asthatmatic)

difficulty breathing

(otherwise ill-defined)

32
Q

coronaviruses limited to

A

upper RT (invects epithelial cells)

34
Q

infection time for parainfluenza viruses

A

fall and winter

34
Q

disease states parainfleunza viruses

type 1-4

A

type 1 Croup

type 2 Croup

type 3 bronchiolitis in small infants

type 4 - mild disease

35
Q

location in RT MERS-CoV

A

lower resp tract (victims with higher viral loads)

36
Q

clinical consequences of respiratory syncytial viral infection

Children < 1

Children

Adults+older children

A

bronchitis, pneumoia, fever cough dypsnea and cyanosis

**children: **febriel rhinitis and pharngitis

**adults+older children: ** common cold

38
Q

ideal temperature coronaviruses

A

33-35

39
Q

disease state resp syncytial virus

A

localized RT infection - no systmemic sprea

airway blockage in infants virused induced CPE includes syncitia (giant cells,) induction of cytonkines

40
Q

respiratory syncytial virus mechanism of airway blockade in infants,

A

virus induced CPE includes syncitia (multinucleated giant cells)

induction of inflammtory cytokines

41
Q

transmission route SARS coronavirus

source

A

face-to-face

source: bats, asian animal markets

43
Q

Rhinovirus ___ resistant to uncoating prevention drug mechanisms

A

rhinovirus C

44
Q

diseases caused by coronaviruses

A

common colds

45
Q

dates and transmission H7N9

october 2 2014

A

does not transmit easily among people

47
Q

all children infected by age 5

A

metapneumovirus

49
Q

vaccine for parainfluenza viruses

A

none

50
Q

clincical conseuquneces of measels infections

A

cough

conjunctivitis

coryza

complications - otitis media, croup, penumonia

(maculopapular rash, photophobia, koplic spots)

51
Q

treatment for severe adenovirus infections in immunocompromised

A

cidofovir

52
Q

infects humans, bats, camels

does not transfer person-to-person readily

A

MERS-CoV