Renal Phys Correlations

Question 1

intracellular water vs extracellular water (total, normal)

Answer 1

27 L intraceullar

15L extracellular

Question 2

endocrine functions of kidney

Answer 2

Renin > converts angiotensinogen> angI

EPO

1,25dihydroxyvitamin D production in proximal tubule cells (Ca and phosphate balance)

Question 3

normal urine output

Answer 3

1-1.5/day

Question 3

nitrogen waste product of protein metabolism

less acurate indicator of GFR than creatine

Answer 3

Blood Urea Nitrogen

Question 4

because ____, creatine clearance overestimates GFR

Answer 4

creatine is also secreted in nephron

Question 4

increased PTH >

Answer 4

Increased renal Ca abs

increase Ca from bone

increased Vit D3 activation

Question 4

Chronic kidney disease > ___ and ___ > secondary hyperparathyroidism

Answer 4

decreased calcitriol porduction, decreased Ca abs

and

Phos retention

Question 5

GFR ~

Answer 5

GFR~100/serum creatine

Question 6

presentation hyponatremia

Answer 6

Nausea/vomiting

weakness

headache

lethargy

seizures

Resp depression

Death

Question 8

direct tubular effects on tubular Na reabsorption

Answer 8

renal symp nerves

Angiotensin II - increase activity of proximal tubule Na/H countertransporter

Question 9

Na osmolarity regulated by

Answer 9

amount of ECW

Question 10

2% of filtered load of Na has its excretion dependent on

Answer 10

aldosterone increasing luminal Na channels and BL Na/K-ATPases

Question 11

estimating GFR from serum creatine Cockcroft-Gault equation

Answer 11

Cr clearance (ml/min) =

(140-age)weight kg / (Serum Crx72)

if female x 0.85

Question 12

systemic response to decreased ECF volume

Answer 12

baroreceptor and sympathetic activation

Renin/AngII/Aldosterone system

ADH

Question 13

impact of increased PO4 in kidney disease on calcium

Answer 13

decreased Ca

Question 15

normal [Na]

Answer 15

intracellular 10mEq/L

extracellular 140mEq/L

Question 16

osmolarity =

Answer 16

total solute / ECF volume

Question 17

normal [K]

Answer 17

intracellular 140mE/L

Extracellular 4mEq/L

Question 18

Innapropriate secretion of ADH in

Answer 18

Cancer (esp Small cell lung)

CNS disease

Pulmonary disease

Drugs (narcotics, antiemetics, SSRIs)

SRIs

Question 19

normal GFR

Answer 19

90-125 ml/min