Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Renal/Resp > Renal Pharm > Flashcards

Renal Pharm Flashcards

1
Q

pharmacokinetics+ therapuetic effect colchincine

A

oral

6-12 hour admin

pain relief at 18hr, max at 48

Reduces inflammation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

____ favors ionization while ____ disfavors ionization

___ percipitates tetany and laryngospasm in Ca deficiency

A

acidosis favors ionization while alkalosis disfavors ionization

hyperventilation percipitates tetany and laryngospasm in Ca deficiency

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

factors underlying increased PTH in secondary hyperparathyroidism

A

decreased calcitriol production (vit D3)

decreased serum Ca

increased serum phos

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

pharmocokinetics Epoetin

A

IV or subq (better response)

half life 4-6 hours

2-3times/week

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

emerging antiapoptotic drugs

A

caspase inhibitors

minocycline (antibiotic)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

signs of 1,25 hydroxy Vita D def in CKD

A

fractures (esp elderly)

hyperparathyroidism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

first generation bisphosphate (simpler side change)

second gen (amino or ntirogenous side chain)

third gen

A

eidronate+tiludronate

2: Pamidronate, aldedronate, ibadronate

3 - Risedronate, Zoledronate

(ET PAI RZ)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

mechanism bisphosphates

A

pyrophosphate analogs

bind hydroxyapatite crystals in bone matrix > inhbit resorption

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

important consideration of calcitriol analogs in kidney disease

A

ergocaliferol, alfacalcidol or calcitriol must be activated in kidney via 1-a activation

must used active form

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

side effects Bisphosphates

A

GI, abdmonial pain

osteonecrosis of jaw (IV)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

drug interactions xanthine oxidase inhibitors allopurinol febuxostat

A

inhibit metabolism of azathioprine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

emerging vasodilators

A

fenoldompam (dopamine)

ANP

(prior to event (thoracic surgery))

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

benefits of renin-angiotensn inhbitors in CKD

A

reduced progression of albuminuria

reduced progression of GFR decline

reduced risk of ESRD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

indications, bisphosphates

A

hypercalcemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

side effects of calcitriol+vitamin D analogs

A

excessive dosing > hypercalcemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

bisphosphate that can supress bone absorption for up to a year (all other have weekly admin)

A

Zoldondrate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

xanthine oxidase inhibitors for gout

A

Allopurinol (purine)

Febuxostat (non-purine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

emerging anti inflammatory drugs

A

adensoine - a2a agonist

phosphatidyserine binding protein

15
Q

mechanism ruasburicase, indication

A

recombinate version of urate oxidase

primarily used as prophylaxis in chemo, also for CKD

16
Q

emerging growth factor drugs

A

recombinant EPO

17
Q

therapeutic effect of EET analogs

A

protect kidney from HTN

18
Q

drug classes to minimize proteinuria in diabetic nephropathy

A

ACEi and ARB

20
Q

therapeutic mechanism Calcitriol and Vitamin D analogs

A

increase synth of Ca channels+calbindin carrier protein

bind cytoplasmic VitD receptor > promotes endocytoic capture of calcium and transport across duodenal mucosa

also

enhances renal tubular reab of Ca

enhances recruitment+dif of osteoclast preccursors for remodeling

21
Q

side effects phosphate binders

A

GI

hypercalcemia

22
Q

due to high PTH levels in CKD, transplant patients may experience

A

hypercalcemia

23
Q

reduced Ca and increased phosphate in kidney disease lead to

A

secondary parathyroidism

(metabolic bone disease, soft tissue calcifications)

24
Q

symptoms of enemia

A

fatigue

decreased cognition

25
Q

half life of intra-musc or SubQ injection of calcitonin

A

20 minutes

(but since hormone, lasting effects)

25
Q

side effects colchincine

A

GI toxicity

rash

27
Q

kidney failure leads to decreased renal excretion of phosphate and diminished production of

A

calitriol

28
Q

impact on Ca levels of hypoalbuminemia

A

no decrease in Ca concentration

30
Q

normal plasma Ca

A

9-11mg/dl

31
Q

side effects Rasburicase

A

Fever

Hypersensitivity

hemolysis (due to hydrogen peroide as by proudct of allantoin)

32
Q

emerging anti sepsis drugs

A

insulin

34
Q

calcitonin produced by

A

parafollicular cells of thyroid

35
Q

calcitriol and vitamin D analogs

A

ergocaliferol

alafacalcidol

paricalcitol

36
Q

side effects Calcitonin

A

facial flushing

headache/dizziness

GI

Taste disturbance

37
Q

side effects EPO

A

headache

flu like symptoms early in treatment

HTN

thrombosis and ateriovenous shunts

pure red cell abx rxn in subQ use

39
Q

phosphate binders

A

calcium carbonate

calcium acetate

lanthanum carbonate

sevelamer (aluminum free)

40
Q

hormones regulating plasma calcium

A

parathormone

calcitonin

calcitriol (active vit D)

41
Q

% of filtered uric acid load that is excreted

A

8-12%

42
Q

side effect xanthine oxidase inhibitors allorpurinol

febuxostat

A

GI

acute gout

hypersensitivity (esp in renal disease pt)

43
Q

halmark of secondary hyperparathyroidism

A

increased PTH

Renal/Resp (43 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions