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Renal/Resp > Renal Phys > Flashcards

Renal Phys Flashcards

1
Q

urine flow rate

A
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2
Q

ICF = ___ of total body water

A

2/3

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2
Q

tubuloglomerular feedback

A

autoreg of kidney

increased perfusion pressure results in increased NaCl to macula densa, resultin in increased vascular resistance

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2
Q

impact on GFR
NE

Epi

endothelin

Angiotensin II

Edothelial NO

Prostaglandins

A

NE - decrease

Epi - decrease

endothelin - decrease

Angiotensin II - no change

Edothelial NO - increase

Prostaglandins increase

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3
Q

renal excretion

A
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4
Q

loop segment

reabsorbs Na

ADH water reabsorption

urea reabsorption

A

medullarly collecting duct

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5
Q

loop segment

impermeable to water

passive reabsorption of sodium, dilution of tubular fluid

permeable to urea > secreted

A

thin ascending loop

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6
Q

loop segment

reabosrption of water secondary to cortical medullary osmotic gradient

A

descending loop

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6
Q

ENaC channel found in

A

apical membrane of principal cells (late distal tubule and cortical collecting duct)

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7
Q

ANP works at

A

distal tubule and collecting duct

decreases Na reabsorption

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8
Q

thiazide diuretics act at

A

Na/Cl transporter of early distal tubule

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9
Q

renal clearance

A
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11
Q

PTH works at

A

proximal tubule: decrease PO4 reabsorption

Thick ascending and distal: increase Ca reabsorption

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12
Q

ADH works at

A

principal cells of late distal and collecting duct, inner medullary collecting duct

increases water reabsorption

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13
Q

_____ blocked by K sparing diuretics at

A

reabsoption of sodium and secretion of potassium blocked by K sparing diuretics at late distal tubule and cortical collecting duct

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14
Q

osolar clearance

A
15
Q

loop diuretics act at

A

thick ascending loop NaK2Cl transport

(furosemide, ethacrynic acid, butmetanide)

16
Q

loop segment

reabsorbs Na Cl Ca and Mg

not permeable to water

Thiazide sensitive

A

early distal tubule

17
Q

aldosterone acts in

A

principal cells of late distal and collecting duct to increase Na reabsorption, increase K secretion

18
Q

Free water clearance equation

A
20
Q

average osmolarity

ECF

ICF

A

ECF = 280-300 mOsm/L

ICF = 280-300mOsm/L

21
Q

angiotensin II acts at

A

primarily proximal tubule to increase Na and water reabsorption,

increase H secretion

22
Q

loop segment

reabsorbs Na

secretes K

regulated by aldosterone

ADH action

A

Principal cells of late distal tubule and cortical collecting duct

23
Q

myogenic mechanism

A

intrinsic prop of blood vessels

stretching from increased pressure results in contraction to maintain blood flow and GFR

24
Q

loop segment

reabsoprs 25% of filtered Na by Na/K/2Cl transport

Lumen positive potential drives paracellular reabsorption of Na K Mg and Ca

impermeable to water, dilutes tubular fluid

A

thick ascending

Renal/Resp (43 decks)

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