Renal Phys Flashcards
urine flow rate
ICF = ___ of total body water
2/3
tubuloglomerular feedback
autoreg of kidney
increased perfusion pressure results in increased NaCl to macula densa, resultin in increased vascular resistance
impact on GFR
NE
Epi
endothelin
Angiotensin II
Edothelial NO
Prostaglandins
NE - decrease
Epi - decrease
endothelin - decrease
Angiotensin II - no change
Edothelial NO - increase
Prostaglandins increase
renal excretion
loop segment
reabsorbs Na
ADH water reabsorption
urea reabsorption
medullarly collecting duct
loop segment
impermeable to water
passive reabsorption of sodium, dilution of tubular fluid
permeable to urea > secreted
thin ascending loop
loop segment
reabosrption of water secondary to cortical medullary osmotic gradient
descending loop
ENaC channel found in
apical membrane of principal cells (late distal tubule and cortical collecting duct)
ANP works at
distal tubule and collecting duct
decreases Na reabsorption
thiazide diuretics act at
Na/Cl transporter of early distal tubule
renal clearance
PTH works at
proximal tubule: decrease PO4 reabsorption
Thick ascending and distal: increase Ca reabsorption
ADH works at
principal cells of late distal and collecting duct, inner medullary collecting duct
increases water reabsorption
_____ blocked by K sparing diuretics at
reabsoption of sodium and secretion of potassium blocked by K sparing diuretics at late distal tubule and cortical collecting duct
osolar clearance
loop diuretics act at
thick ascending loop NaK2Cl transport
(furosemide, ethacrynic acid, butmetanide)
loop segment
reabsorbs Na Cl Ca and Mg
not permeable to water
Thiazide sensitive
early distal tubule
aldosterone acts in
principal cells of late distal and collecting duct to increase Na reabsorption, increase K secretion
Free water clearance equation
average osmolarity
ECF
ICF
ECF = 280-300 mOsm/L
ICF = 280-300mOsm/L
angiotensin II acts at
primarily proximal tubule to increase Na and water reabsorption,
increase H secretion
loop segment
reabsorbs Na
secretes K
regulated by aldosterone
ADH action
Principal cells of late distal tubule and cortical collecting duct
myogenic mechanism
intrinsic prop of blood vessels
stretching from increased pressure results in contraction to maintain blood flow and GFR
loop segment
reabsoprs 25% of filtered Na by Na/K/2Cl transport
Lumen positive potential drives paracellular reabsorption of Na K Mg and Ca
impermeable to water, dilutes tubular fluid
thick ascending
