Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Systemic Path > Resp 2 > Flashcards

Resp 2 Flashcards

1
Q

What are type I pneumocytes

A

extremely thin squamous (flattened) cells that line 95% of the total
alveolar surface. They are specialized for GAS EXCHANGE and are INCAPABLE OF CELL DIVISION

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are type II pneumocytes

A

are cuboidal cells interspersed among type I cells. They are as numerous as type I, but cover only 5% of the alveolar air surface. they secrete SURFACTANT and are PROGENITOR CELLS FOR TYPE I PNEUMOCYTES

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

what two things are important about type I pneumocytes

A

gas exchange and can’t divide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

what two things are important about type II pneumocytes

A

secrete surfactant and are progenitor cells for type I pneumocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what does type II pneumocyte hyperplasia indicate

A

alveolar injury in the lungs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What are the 6 things that compose the blood-air barrier?

A
  1. Alveolar surfactant
  2. Type I pneumocytes
  3. Basal lamina of type I pneumocytes (the “stuff” the cells sit on)
  4. Interstitial connective tissue*
  5. Basal lamina of capillary endothelial cell
  6. Capillary endothelial cell

** = not always present

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

The blood-air barrier consists of (This time only 3 things for some reason the notes say it twice & in different ways) :

A
  1. Type I pneumocytes cytoplasm
  2. A dual basal lamina – formed by the fusion of the basement membranes of both the endothelial cell and the type 1 pneumocyte.
  3. Cytoplasm of endothelial cell
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

where are club cells found

A

Club cells are found in bronchioles. BE CAREFUL! Do not confuse club cells with
Type 2 pneumocytes, which are found in the alveoli.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

are club cells equivalent to type II pneumocytes

A

no way !!!! club cells = in bronchioles, type II pneumocytes = alveoli

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Atelectasis

A

incomplete distension (or inflation or expansion) of alveoli. Atelectatic portions of the lung are sunken and darker in color. (Think solid, jersey mild chocolate bar instead of aero bar)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is congenital atelectasis

A

Congenital or neonatal atelectasis occurs because the lungs are not inflated with air at birth. This can occur because of aspiration of amniotic fluid, meconium and/or squamous
epithelial cells which can cause obstruction of small bronchi and bronchioles at the time
of birth. In some cases (for example premature births), there may be a surfactant problem (either
not enough produced, or poor quality), which means alveolar septa stick together and
can’t stay open.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is acquired atelectasis

A

collapse of the lung after inflation has already taken place. Two types: Compressive or obstructive

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what is compressive atelectasis

A

the lungs are compressed by something outside the lungs but within the thoracic cavity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

what is obstructive atelectasis

A

something has blocked an airway (within the lung itslef) preventing airflow and causing alveolar collapse

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What are some examples of causes of compressive atelectasis

A

space occupying thoracic masses (tumors, abscesses) or transferred pressures (pneumo/hydro/chylo/hemo thorax)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What are some causes of obstructive airways

A

lumen narrowed (mucosal edema or inflamation) or lumen blocked (mucus, exudate, lungworms, aspirated material)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

what is emphysema

A

over distension and rupture of alveolar walls forming air bubbles in the lung tissue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

what type (primary or secondary) emphysema occurs in animals

A

secondary

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

what is secondary emphysema

A

distension and rupture of alveolar walls forming air bubbles in lung parenchyma which develops as a consequence of some predisposing condition or disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

what are the two causes of secondary emphysema that are often seen in animals

A
  1. obstruction of outflow of air (as in bronchopneumonia)
  2. agonal at slaughter (from gasping against closed airways)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

why does obstruction of air outflow lead to secondary emphysema

A

Air can squeeze past the obstruction on inspiration, however, on expiration (exhalation),
the lung contracts a bit, narrowing the airway slightly, and blocking escape of the air. Eventually there is overinflation and rupture of the alveoli (think of blowing up a balloon
too much and then… POP!).

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

how to differentiate secondary emphysema from obstruction vs agonal at death

A

agonal at death tends to only occur at the distal edges of the lungs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

what is pulmonary congestion

A

accumulation of blood and fluid in the lungs. It is a PASSIVE process

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

what are heart failure cells

A

alveolar macrophages filled with chewed up red blood cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

what are the two main categories of pulmonary edema

A

cardiogenic and permeability

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

what is cardiogenic pulmonary edema

A

there is either increased hydrostatic pressure (like in CHF) or an increased volume of blood (like in pulmonary congestion), or hypoproteinemia, or lymphatic obstruction.

These are just your Starling forces.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

what is permeability pulmonary edema

A

AKA inflammatory pulmonary edema. Usually develops due to generalized inflammation of the lung or if there is damage to the pneumocytes that line the alveoli (both of these increase vascular permeability)

28
Q

A lesion that you might see on post-mortem examination of an animal that might indicate that
pulmonary edema was the cause of death is

A

Froth in the trachea

29
Q

T/F: even a small amount of froth in the lungs is enough to incriminate pulmonary edema as the cause of death in an animal at necropsy

A

FALSE. you need EXTENSIVE froth to kill an animal, plus mild lung edema often develops at the time of death regardless of the actual cause of death

30
Q

in addition to froth, what are three other lesions that indicate pulmonary edema?

A
  1. lungs fail to collapse when cavity is opened
  2. edematous lungs will have prominent interlobular septa
  3. lungs are often darker than normal, wet, and heavier than normal
31
Q

At necropsy, lung tissue oozes red-tinged fluid and you can see foamy fluid in the bronchi. What does this indicate

A

Pulmonary edema

32
Q

What are the four main types of pneumonia

A
  1. Bronchopneumonia
  2. interstitial pneumonia
  3. granulomatous pneumonia
  4. Embolic pneumonia

ACRONYM: BIG E

33
Q

what is pneumonia

A

Any inflammatory lesion in the lung

34
Q

what is the difference between pneumonia and pneumonitis

A

there isn’t any. They’re the same thing.

35
Q

what is the most common form of pneumonia

A

bronchopneumonia

36
Q

Bronchopneumonia: important details

A
  • centered on airways, often contain exudate
  • cranioventral consolidation
  • caused by inhalation or aspiration of bacteria, stomach contents, or stomach tubing contents.
37
Q

What are the two types of bronchopneumonia

A

Suppurative (lobular)

Fibrinous (lobar)

38
Q

the cranioventral portion of a lung is dark red to purple and feels firm. What is your diagnosis

A

bronchopneumonia

39
Q

if there is dark grey to black areas of lung tissue due to aspiration of stomach acid in the cranioventral portion, what should your diagnosis be

A

necrotizing bronchopneumonia

40
Q

what are the 3 common sequelae of suppurative bronchopneumonia

A
  1. pleural adhesions (fibrous, tough adhesions between the visceral and parietal pleura)
  2. lung abscesses (pockets of purulent material in the lung)
  3. bronchiectasis (rupture of the bronchial wall)
41
Q

Which (fibrous vs fibrinous) adhesions are permanent

A

fibrous

42
Q

What do fibrous adhesions on the lungs indicate

A

only indicate that the animal had a previous pneumonia, not necessarily that is currently had pneumonia at the point of death

43
Q

What indicates chronic bronchopneumonia?

A

fibrous adhesions AND abscesses

44
Q

what is bronchiectasis

A

the rupture and dilation of a bronchial wall due to the effects of enzymes
(produced and secreted by neutrophils and macrophages) during inflammation. The enzymes degrade the bronchiole, therefore this is a IRREVERSIBLE lesion. It is also COLLATERAL DAMAGE to the airway due to the inflammatory process

45
Q

What is the only way to determine the difference between a lung abscess and bronchiectasis

A

histology!!!! a lung abscess is surrounded by a fibrous tissue capsule. Bronchiectasis will still have remnants of airway (bronchial cartilage) surrounding the purulent center

46
Q

difference between fibrinous and fibrous adhesions

A

fibrinous - yellow, easy to pull off

fibrous - white, shiny, hard to pull off (think of tape on cardboard).

Has to do with the chronology of the lesion - fibrin indicates active (acute or subacute) process. Fibrous indicates scarring, and therefore chronic processes.

47
Q

Important details on interstitial pneumonia

A

inflammation is centered on alveolar interstitium.

There are many different etiologies (viruses, toxic gases, Ag-Ab complex deposition, endothelial damage…)

lungs are diffusely rubbery or meaty, frequently have rib imprints, and fail to collapse.

48
Q

Rib impressions on the UP side is important to diagnose

A

interstitial pneumonia

49
Q

what causes the rubbery texture of the lungs in interstitial pneumonia

A

hypercellularity and edema of the interstitium.

50
Q

T/F: interstitial pneumonia is caused by inhaled bacteria and is centered on airways

A

FALSE. This refers to bronchopneumonia. Bacteria doesn’t cause interstitial pneumonia, and inflammation is centered on the connective tissue, not the airways

51
Q

what are three clues that indicate interstitial pneumonia

A
  • all lung lobes are affected (diffuse distribution)
  • faint rib impressions on the caudal lung surface
  • lungs fail to collapse
52
Q

T/f you can diagnose bronchointerstitial pneumonia based on gross examination of lung

A

FALSE. this requires histology

53
Q

Granulomatous pneumonia: important details

A
  • granulomas distributed throughout lung.
  • caused by:
    1. phagocytosis-resistant bacteria
    2.systemic fungal disease
    3. parasites or FBs
    4.systemic infection
  • route of entry is either AEROGENOUS (inhaled), or BLOOD BORNE (hematogenous)
54
Q

Embolic pneumonia: important details

A

inflammation is centered in pulmonary blood arterioles and capillaries

hematogenous.

begins with hyperemic or hemorrhagic foci which progress into abscesses.

Diffuse, random distribution

55
Q

T/F phagocytosis-resistant bacteria like Mycobacteria or Rhodococcus cause embolic pneumonia

A

FALSE. These cause granulomatous pneumonia

56
Q

What is required to differentiate granulomatous pneumonia from embolic pneumonia

A

histology

57
Q

What is hydrothorax

A

accumulation of a transudate (usually clear yellowish to red
fluid)

58
Q

what is hemothorax

A

accumulation of blood in the chest cavity (should see blood
clots!)

59
Q

what is chylothorax

A

ccumulation of lymph or chyle. This is usually an opaque,
“milky”, white fluid

60
Q

what is pyothorax

A

accumulation of purulent exudate or “pus” in the thorax. Pus is
also a white fluid, which sticks to the surface of the thoracic organs

61
Q

what is pneumothorax

A

accumulation of air in the thorax.

62
Q

T/F chyle adheres to the outer surface of the lungs or pericardium

A

false. this occurs with fibrinous purulent exudates in the thorax, but not with chyle.

63
Q

on necropsy, you notice a dull, tan to grey exudate that sticks to the pleural surface and the surface of the pericardium. What is you diagnosis

A

pyothorax. (NOT chylothorax, which may look the same but doesn’t stick)

64
Q

T/F pleuritis may make it hard for an animal to breathe, but it is not painful in itself.

A

FALSE!!!! its super super painful

65
Q
A

Systemic Path (19 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions