reproductive 2

Question 1

what are androgens

Answer 1

steroid hormones that have anabolic and masculinizing effects

Question 2

where is testosterone produced three places

Answer 2

Leydig cells of testies, ovaries, and zona reticula cells of adrenals

Question 3

Moa of testosterone

Answer 3

alter gene transcriptom

Question 4

what is the more bioactive form of testosterone

Answer 4

dihydrotestosterone

Question 5

how is dihydrotestosterone made

Answer 5

5 alpha reductase enzyme,

Question 6

what hormones metabolize testosterone

Answer 6

5 alpha reductase to dihydrotestosterone and aromatase to estrogen

Question 7

to effects of testosterone

Answer 7

androgenic and anabolic

Question 8

adrogenic effects

Answer 8

secondary male characteristic, sperm, fertility etc

Question 9

anabolic effects

Answer 9

building strong bones and muscles and RBCs

Question 10

inaequate testosteron production

Answer 10

hypogonadism

Question 11

two reasons to supplement testosterone,

Answer 11

hypogonadism and dwarfism from pit

Question 12

signs of hypogonadism

Answer 12

loss of 2nd sex characteristic, sexual dysfunction, osteoporosis,

Question 13

indications for testosterone administration

Answer 13

anemia, severe osteoporosis, hormone therapy trans, anti aging

Question 14

ratio of androgenic to anabolic activity in exogenous testosterone

Answer 14

1:01

Question 15

are oral preparations of testosterone effective?

Answer 15

Oral is less effective because of first pass metabolism, sublingual iare thought to be effective

Question 16

what did old oral testosteron do

Answer 16

increase risk of liver disease and hepatitis and hepatic cancer

Question 17

adverse effects of excess androgens

Answer 17

Prostatic cancer, gynecomatia, baldness, acne - Women: virilization, acne, excess body hair, clit enlargemtn, menstral irregularities - Children: short stature closure of growth plates

Question 18

high dose, unauthorized

Answer 18

roid rage, breast cysts, cystic acne, liver abnormalities

Question 19

Labs adverse effects

Answer 19

abnormal lipid levels, fluid retentin, increase RBC mass to increase viscositis, to increase ischemia

Question 20

what are anabolic steroids

Answer 20

synthetic derivative of testosterone which have anabolic effect > androgenic effect