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pharmacology II > key antispycotic > Flashcards

key antispycotic Flashcards

1
Q

who should not use antipsycotics

A

elderly and dementia

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2
Q

what do most antipsycotics do

A

aim to decrease the effects of Dopamine and serotonin

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3
Q

compare most antispycotics to most anti anxiety

A

anti anxity is trying to increase some combo of Dopa and serotonin and NE while antipsycotis is trying to decrease dopa and serotonin

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4
Q

3 main class of antispycotixs

A

typical - atypical and lithium salts

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5
Q

Lithiam carbonate

A

dampen NE and diminish glutamate response to treat Bipolar - DI - hypothyroid - decreased response to ADH

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6
Q

zyprexa

A

block D2 and serotonin receptors - wt gain - stroke - DM

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7
Q

respiradone

A

block D2 and serotonin receptors - wt gain - stroke - DM - not for elderly

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8
Q

clozapine

A

block D2 and serotonin receptor - schizo - myocarditis and agranulocytosis

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9
Q

haldol

A

block D2 receptor block - turrets - huntingtons - aggitated - causes extrapyramidal effects like tremor and neuroleptic malignant syndrome

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10
Q

what antipsycotic can act as antiemetic

A

compazine -H1 then D2 receptor blocker

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11
Q

Compazine

A

H1 then D2 receptor blocker - antiemetic less side effects than thorazine - migraines

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12
Q

Thorazine

A

D2 then HI then alpha receptor blocker - Increase prolactin - infertility-

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13
Q

what is the Dopamine antagonist antidote

A

bromocryptine/parlodel a drug also used in parkinsons dz for tremors

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14
Q

what is neuroleptic malignant syndrome

A

possible fatal, catatonia, changing BP , fever, dysarthria - antidote is bromocryptine/parodel

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15
Q

what are antipsycotics in general

A

they are tranquelizers wit lots of signifigant side effects but are not for dementia

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16
Q

blockage of what receptor has the antipsycotic response

A

D2

17
Q

how do the typical differe from the atypical

A

Typical is Dopamin block and atypical block dopamine and serotonin

18
Q

what is the concern with chronic treatment with neuroleptic drugs

A

extrapyramidal signs - dardive dyskinesia - inappropriate prosturing

19
Q

akinesia

A

cant start movement

20
Q

akathisia

A

can remain still

21
Q

dyskinesia

A

involindary movement

22
Q

what antispycotic is best for severe combative behavior

A

halidol - D2 blockaide - careful to reduce risk of tardive and neuroleptic malignant syndrome

23
Q

what do all atypicals have

A

increased weight gain and DM and risk of stroke in elderly

24
Q

what antipsycotic dose must be reduced in liver dysfunction

A

Respiradone

25
Q

what is lithium used for

A

mania - it dampens NE transmission

26
Q

what must be done if on lithium

A

blood monitor levels - narrow theraputic dose

27
Q

what antipsycotic causes renal dysfunction

A

litium - DI from reduced renal response to ACH

pharmacology II (31 decks)

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