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pharmacology II > Derm/ drug/MOA > Flashcards

Derm/ drug/MOA Flashcards

1
Q

Topica antibiotics

A

Polymyxin B/neosporin
Mupirocin/Bactroban
Bacitracin(often mixed with neosporin)

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2
Q

MOA: polymyxin B

A

disrupt cell membrane/phospholipids

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3
Q

MOA Mupirocin/bactroban

A

disrupt protein synthesis

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4
Q

MOA bacitracian

A

disrupt cell wall : peptidoglycan

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5
Q

Indication Polymyxin B

A

Superficial skin infection

External ear infection

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6
Q

Indication for Mupirocin/bactroban

A

Impetigo,

staph/strep

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7
Q

Topical antifungals

A

Ketoconazole/nizarol

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8
Q

MOA topical antifungal : ketoconazole/nizarol

A

Inhibit sterol synthesis

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9
Q

indication for Ketoconazole/nizarol

A

Tinea
yeast
seborrheic derm

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10
Q

What drug disrupst protein synthsis

A

Mupirocin/bactroban : topical antibiotic

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11
Q

What drug disrupts cell membrand Phospholipids

A

Polymyxin B/neosporen: topical antibiotic

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12
Q

what drug disrupts cell wall peptidoglycan

A

Bacitracin ( often mixed with neosporen)

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13
Q

what drug inhibits sterol synthesis

A

Ketoconazole/nizarol: topical antifungal

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14
Q

Glucocorticoid/corticosteroids

A

Hydrocortizone/Cortef

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15
Q

MOA Hydrocortizone/Cortef

A

anti-inflammatory, alter gener transcription to stimulate or supress protein synthesis

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16
Q

indications for Hydrocortizone/Choteif

A

Psoriasis
eczema
dermatitis
SLE

17
Q

side effects of corticosteroids/hydrocortizone/choteif

A

supression HPA access, hyperglycemia

  • Rosacea
  • perioral derm
  • skin atrophy/striae
  • hypopigmentation/ purpura
18
Q

Vitamin A derivatives

A

Tretinoin/retin A

Isoretinoin/Accutane

19
Q

MOA of Tretinoin/retin A

A

MOA tretinoin

  • reduce hyperkeratoinization
  • increase dermal thickness and collagen
20
Q

what is indicated for Acne and photodamaged skin

A

Tretinoin/Rtin A: Vit A derivative

21
Q

MOA of isoretinin/Accutain

A

Reduce hyperkeratinization
reduce sebaceous gland number and production
reduce propionbacterium acne

22
Q

indication for isoretinin/Accutain

A
  • Acne
  • acne rosacea
    hidradenitis supperativa
23
Q

side effects of Retin A

A
  • redness, peeling, burning photosensitiviy
24
Q

what has side effect of seeratogenicity

A
  • isoretinin/Accutain: first 3 weeks is worst
25
Q

side effects of isoretinin/Accutatin

A
  • Teratogenic
  • psycosis
  • liver ailments

pharmacology II (31 decks)

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