Derm/ drug/MOA Flashcards
Topica antibiotics
Polymyxin B/neosporin
Mupirocin/Bactroban
Bacitracin(often mixed with neosporin)
MOA: polymyxin B
disrupt cell membrane/phospholipids
MOA Mupirocin/bactroban
disrupt protein synthesis
MOA bacitracian
disrupt cell wall : peptidoglycan
Indication Polymyxin B
Superficial skin infection
External ear infection
Indication for Mupirocin/bactroban
Impetigo,
staph/strep
Topical antifungals
Ketoconazole/nizarol
MOA topical antifungal : ketoconazole/nizarol
Inhibit sterol synthesis
indication for Ketoconazole/nizarol
Tinea
yeast
seborrheic derm
What drug disrupst protein synthsis
Mupirocin/bactroban : topical antibiotic
What drug disrupts cell membrand Phospholipids
Polymyxin B/neosporen: topical antibiotic
what drug disrupts cell wall peptidoglycan
Bacitracin ( often mixed with neosporen)
what drug inhibits sterol synthesis
Ketoconazole/nizarol: topical antifungal
Glucocorticoid/corticosteroids
Hydrocortizone/Cortef
MOA Hydrocortizone/Cortef
anti-inflammatory, alter gener transcription to stimulate or supress protein synthesis
indications for Hydrocortizone/Choteif
Psoriasis
eczema
dermatitis
SLE
side effects of corticosteroids/hydrocortizone/choteif
supression HPA access, hyperglycemia
- Rosacea
- perioral derm
- skin atrophy/striae
- hypopigmentation/ purpura
Vitamin A derivatives
Tretinoin/retin A
Isoretinoin/Accutane
MOA of Tretinoin/retin A
MOA tretinoin
- reduce hyperkeratoinization
- increase dermal thickness and collagen
what is indicated for Acne and photodamaged skin
Tretinoin/Rtin A: Vit A derivative
MOA of isoretinin/Accutain
Reduce hyperkeratinization
reduce sebaceous gland number and production
reduce propionbacterium acne
indication for isoretinin/Accutain
- Acne
- acne rosacea
hidradenitis supperativa
side effects of Retin A
- redness, peeling, burning photosensitiviy
what has side effect of seeratogenicity
- isoretinin/Accutain: first 3 weeks is worst
side effects of isoretinin/Accutatin
- Teratogenic
- psycosis
- liver ailments
