Primary Biliary Cirrhosis Flashcards
1
Q
what is it
A
chronic inflammation and destruction of intra- and extra- hepatic bile ducts leading to build up of bile in liver, causing cirrhosis
2
Q
who is most commonly affected
A
middle aged women
3
Q
what are symptoms
A
itch without rash fatigue xanthelasma arthralgia oeteoporosis hepatosplenomegaly jaundice
4
Q
how is it diagnosed
A
LFTs show cholestatic pattern
increased IgM
AMA+ve, ANA+ve
liver biopsy
5
Q
how is it treated
A
urseodeocycholic acid azathioprine (immunosuppression) prednisolone (steroid) treat complications (osteoperosis) liver transplant
6
Q
what are the complications
A
most will not develop symptoms
majority of people with PBC symptoms do not develop liver failure BUT still common cause for liver transplantation
