Gastric Cancer Flashcards

1
Q

what are the benign tumours

A

polyps - rare

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2
Q

what are the malignant tumours

A

adenocarcinoma
gastrointestinal stromal tumours (GISTS)
Lymphomas (MALTomas)

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3
Q

what are characteristics of gastrointestinal stromal tumours

A

mesenchymal tumours affecting people aged 55-65

linked with defect of pacemaker cells (ICC)

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4
Q

characteristics of lymphomas

A

derived from mucosa-associated lymphoid tissue
associated with H. pylori
involve B cells in lymph nodes primarily

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5
Q

what is adenocarcinoma

A

tends to occur proximally in cardia/GO junction region

prevalence increase with age; slightly more common in males

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6
Q

how does adenocarcinoma have a strong link with H. pylori

A

H. pylori –> chronic gastritis –> metaplasia –> dysplasia –> carcinoma

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7
Q

what is type 1 adenocarcinoma

A

intestinal (polypod mass) - better prognosis

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8
Q

what is type 2 adenocarcinoma

A

diffuse (expansive, infiltrative mass)

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9
Q

what are symptoms

A
dyspepsia and alarm symptoms
epigastric pain 
loss of appetite and weight 
vomiting (hematemesis in later stages)
dysphagia
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10
Q

how is adenocarcinoma diagnosed

A

upper GI endoscopy
chest X ray
Biopsy
CT scan

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11
Q

how is adenocarcinoma treated

A

if proximal - total resection
if distal - partial resection
palliative care
combination chemotherapy appears to increase survival in advanced disease

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