Coeliac Disease Flashcards
1
Q
what is it
A
autoimmune inflammation of the small bowel in response to presence of gluten
villi become flattened, reducing capacity for absorption
2
Q
what genes associated
A
HLA DQ2 and DQ8
3
Q
what is prevalence
A
1:100
1st relatives have 10-15% risk
female 2:1 males
4
Q
what are symptoms
A
asymptomatic, non specific diarrhoea steatorrhoea abdominal pain mouth ulcers angular stomatitis weight loss anxiety and depression
5
Q
how is it diagnosed
A
blood tests
small bowel biopsy
histology
DEXA bone scan
6
Q
what looking for in blood test
A
tTGA IgA and EMA (IgA endomysial antibodies)
7
Q
what look like in biopsy
A
villous atrophy, crypt hyperplasia and increased lymphocytes
8
Q
why is DEXA bone scan used
A
assess osteoporosis
9
Q
what is the treatment
A
mineral and vitamin replacement (compensate for malabsorption)
gluten free diet for life - no wheat barely or rye
