Pharmacology Terminology Flashcards
What is Pharmacology?
Science that deals with the study of drugs and their interaction with living systems
Derived from Greek words
“Pharamcon” meaning,,?
“Logos” meaning..?
Biologically active substance
Study
Derived from a French word
“Drogue”
Drug
Examples of Drugs
Natural or Synthetic
Tylenol
Trade Name
Acetaminophen
Generic Drug Name
N-(4- Hydroxyphenyl) Acetamide
Chemical Drug Name
PharmacoKINETICS
Study of what the BODY does to a DRUG Body -> Drug Absorption Distribution Metabolism Excretion
ABSORPTION
DISTRIBUTION
METABOLISM
EXCRETION
PharmacoKINETICS
PharmacoDYNAMICS
Study of EFFECTS of the DRUG on the BODY
Drug -> Body
Effects of Pharmaceuticals
Therapeutic Effect
Adverse Effect
The INTENDED EFFECT of the drug on the body
Therapeutic Effect
Effects of the drug on the body that are nuisance and cause slight discomfort
Side Effect
Ingredient in a drug that is biologically active
Active Ingredient
Inactive compound metabolized in the body to create the drug
Prodrug
Amount of time a product is left to use
Shelf Life
Estimated date based on drug stability test
Expiration
Specific instructions how to use the drug
Labelled Indication
Use of pharmaceutical drugs for an unapproved indication
Off Label Prescribing
Substance
Ligand
Where does a Ligand bind to create a drug - receptor complex?
Receptor
Type of drug that binds to cells to produce an ENHANCE physiological response?
“switched on” effect?
Agonist
Type of drug that BLOCKS access to a receptor and results in a REDUCED cellular activity?
Antagonist
Effect that is undesired and a harmful effect resulting from a medication or other intervention
Unwanted, uncomfortable and dangerous effect
Adverse Effect
Entrance or movement of a drug into the blood stream
Must be dissolve in body fluids except IV
Absorption
Disbursement of unmetabolized drugs as it moves through the body’s blood and tissues
Distribution
Factors that affect drug ABSORPTION
Formulation of Drug pH Gut Motility First Pass Metabolism Lipid Solubility
Organ responsible for drug METABOLISM
LIVER
Organ responsible for drug EXCERETION
KIDNEYS
Factors that may impact the effect of the drug on the patient
Body Weight Age Sex Race Diet Genetic Factors
Movement of drugs across biological membranes
Passive Transfer
Carrier Mediated Transfer
Endocytosis
Simple diffusion (high to low concentration) Filtration through Aqueous pores
Passive Transfer
Facilitated Diffusion
Active Transport
Carrier Mediated Transport
Cells absorb external material by engulfing it with the cell membrane
Endocytosis
What impacts the rate of DISTRIBUTION
Lipid Solubility
Blood flow
Ionization
Biochemical Transformation
First Pass _____
Liver
Metabolism
Elimination of the drug - Renal - Fecal - Pulmonary - Glands Kidney
Excretion
