Drug Delivery Routes Flashcards
Systemic
Enteral and Parenteral
Local
Topical
Drug to Body
Refers to the GI Tract
(oral, duodenal, gastric, rectal)
Enteral
Oblong Shape
Enteral
Capsule
Round shape
Enteral
Tablet
Cross shaped
Enteral
Caplet
Prevents dissolving quickly
Enteral
Enteric Coated
Advantages of Enteral
Safe Convenient Self Administered Economical Non Invasive
Disadvantage of Enteral
Slow Action
GI Irritation
Cannot be given to unconscious patients
May undergo First Pass Metabolism
Going to the tissues
Outside the GI Tract
Parenteral
Injecting through SKIN
Parenteral
Intradermal
Injecting UNDER the SKIN
ex. insulin
Parenteral
Subcutaneous
Injecting directly ON THE MUSCLE
(IM)
Large skeletal
Parenteral
Intramuscular
IM
Injecting into a VEIN
Parenteral
Intravenous
(IV)
Gaseous substance is introduced to the body via Pulmonary Epithelium - Respiratory System
Parenteral
Inhalation
Used to release a drug slowly by absorption on the skin
Ex Patches
Parenteral
Transdermal
Giving a drug across mucous membranes in the mouth
Parenteral
Transmucosal
Behind the Eye
Paralyze it
Retrobulbar
Injecting into the Episclera
Subconjunctival
Injecting into the Anterior Chamber
Intracameral
Injecting into the Vitreous
Intravitreal
Advantages of Parenteral
Rapid More predictable Avoids first pass metabolism Avoids GI irritation Easy for unconscious patients
Disadvantages of Parenteral
May be painful Could damage the nerves More expensive Less safe Keep everything sterile
Application of drug to the skin or mucous membranes
Local
Topical
Topical Medical Administration
Ointment Cream Gel Powder Paste Mucous Membrane
Advantages of Local
Low risk of systemic adverse effects Low risk of drug interactions Small amount of drug is used Ease of administration to uncooperative / unconscious patients Low cost Avoids first pass metabolism
Disadvantages of Local
Potential allergic contact dermatitis
Reduced penetration to target area
Thickness of skin impacts absorption speed
Time consuming to apply
Innovative Drug Delivery Advantages
Improves compliance Drug stays in the tissue even after lens removal Continuous drug delivery Avoids need for drops or surgery Not very invasive
Suppositories
Absorbed through the butt
? Feeding tubes in the intestine
Gastrostomy Tube
Sublingual
Under Your Tongue