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Systemic Ocular Pathology and Pharmacology > Ophthalmic Pharmaceuticals : Corticosteroids and NSAIDs > Flashcards

Ophthalmic Pharmaceuticals : Corticosteroids and NSAIDs Flashcards

1
Q

Where is the Arachidonic Acid released from? and what does it cause?

A

Phospholipid Membrane Layer

Inflammation

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2
Q

Are corticosteroids man made durgs?

A

Yes

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3
Q

What effect does Corticosteroid mimick?

A

Cortisol

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4
Q

Are Corticosteroid Anti-Inflammatory at low doses or at high?

A

Low doses

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5
Q

Are Corticosteroids Immune Suppressive at low does or at high?

A

High doses

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6
Q

What is the Mechanism of Action of Corticosteroids?

A

Inhibit Phospholipase A2

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7
Q

What is the enzyme that Corticosteroids inhibit?

A

Phospholipase A2

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8
Q

What does Corticosteroid prevent the release of?

A

Arachidonic Acid

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9
Q

Are Corticosteroids anti inflammatory?

A

Yes

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10
Q

What are the Ophthalmic Use for Corticosteroids?

A

Conjunctivitis
Iritis
Inflammatory Dry Eye disease
Ocular Allergies

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11
Q

What are examples of STRONG Corticosteroids?

A
  • PredForte (Prednisolone Acetate Suspension 1%)
  • Durezol (Difluprednate Emulsion (0.05%)
  • Lotemax (Loteprednole Etabonate 0.5%)
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12
Q

What are examples of MILD Corticosteroids?

A
  • Alrex (Lotepredno Etabonate Susp 0.2%)

- FML (Fluoromethalone Acetate gel or ung 0.1%)

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13
Q

What are Adverse Effects for Corticosteroids?

A

Elevated IOP
Cataracts
Delayed wound healing
Increased risk of infection

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14
Q

What does NSAIDs stands for?

A

Non Steroidal Anti Inflammatory Drug

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15
Q

Where does NSAIDs act on?

A

Arachidonic Acid Pathway

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16
Q

What does NSAID inhibit?

A

COX Pathways

17
Q

What is the Mechanism of Action of NSAIDs?

A

Inhibit Cyclooxygenase Enzymes
- COX 1 and COX 2
Prevents the production of Prostaglandins

18
Q

Is NSAID anti inflmmatory?

A

Yes and Analgesic

19
Q

What does COX 1 release?

A

Prostaglandins and Thromboxane

20
Q

What does COX 2 relase?

A

Prostaglandins ONLY

21
Q

What is the Ophthalmic Use for NSAIDs?

A

Treat pain and inflammation after cataract surgery
Treat cystoid macular edema
Off label for pain management

22
Q

What are examples of NSAIDs?

generic ends in ac

A

Acular LS (Ketorolac Tromethamine sol 0.4%)
Voltaren (Diclofenac sodium fel 1%)
Ilevro (Neprafenac susp 0.3%)
Prolensa (Bromfenac sol 0.07%)

23
Q

What are adverse effects for NSAIDs?

A

Burning, Stinging, Hyperemia
Corneal Melts
Corneal Ulceration

Systemic Ocular Pathology and Pharmacology (34 decks)

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