pertussis + parapertusis Flashcards
IP
7-10 DAYS
how long does cough last
100 day cough
epi
young infants
complication
hernia
subconjunctival hemorrhage
pertussis pneumonia
when does the cough typically get worse
night
mb
gram -
coccobacilli
strict aerobe-respiratory
fastidious
moa
respiratory droplets
pathogenetic factors
nb! this diesease is primarily a toxin mediated disease!
both exo and endo toxins
1. pertussis toxin A + B causes the systemic toxicity
2. filamentous hemagglutinin- helps anchor to ciliated cells
3. tracheal endotoxin - damages ciliated cells/paralyses, causing inflammation
4. adenylate cyclase toxin - increases camp so increased secretions harder to breathe
stages
- ip
- catarrhal/common cold phase/corzygal symptoms ( a mild cough that gradually becomes more sever)
- paroxysmal phase/severe coughing
- convalescent
tx
its primary supportive but antibiotics can be used macrolides for 2 weeks
prophylaxis
DPT vaccine contains the toxoids of D,T and the subunit of bortatella
most infective stage
common cold phase
how long does each stage last
ip=7-10 days
catarrhal - 1-6 weeks (but can be longer)
paroxysmal - 2-4 weeks- cough still there but milder
how has the vaccine helped
since the widespread vaccine use cases have went down more than 80% since pre vaccine, this disease used to be a major cause of childhood mortality in the 20th century
paroxysmal phase
this is when you are most likely to diagnose it as the cordial phase is not specif, patient has burst of coughing due to trying to clear the thick mucous . AT THE END OF THE PAROXYSM A LONG INSPIRATORY EFFORT IS MADE WITH A CHARACTERISTIC WHOOP
during such an attack patient may become cyanotic
