hemorrgaic fevers overview

Question 1

dic

Answer 1

found in any severely ill patient but is thought to occur more regularly in crimean Congo hemorrhagic fever and HFRS

Question 2

specific organs

Answer 2

In some viral HF, specific organs may be particularly impaired, such as: the kidney in haemorrhagic fever with renal syndrome (HFRS, the lung in hantavirus pulmonary syndrome, and the liver in yellow fever BUT IN ALL HF’S the generalilised circulatory disturbance is cortically important

Question 3

general features

Answer 3

starts as a flu like illness that rapidly progresses to a systemic illness and fatality rates can be 90%

pharangyeal hyperaemia
conjunctival suffusion
cutaneous flushing
chest pain + abdo pain

Question 4

classes of virus

Answer 4

arena
filo
flavi
bunya

Question 5

bunya category

Answer 5

hanta virus +Rift Valley

Question 6

arena virus category

Answer 6

lassa fever

Question 7

fill category

Answer 7

ebola + marking

Question 8

main pathogenetic factors

Answer 8

damage to the vascular system
pro inflammatory cytokines
damage to target organ

Question 9

general labs

Answer 9

increase liver enzymes
plT down
pt elevated
hemoconcetration from leakage (most marked in hanta virus + dengue shock syndrome

Question 10

diagnosis

Answer 10

1. rt- pcr first
2. elisa

Question 11

dx

Answer 11

malaria, thyphoid

Overwhelming parasitaemia/ septicaemia may produce a similar clinical picture and require to be excluded, eg. meningococcus, snake bite, tryponosomiasis

Question 12

HFRS labs

Answer 12

1. proteinurie
2. LEUKOCYTOSIS
3. hyposthenuria
4. thrombocytopenia

Question 13

treatment for HFRS

Answer 13

ribarin (remember same for CCHF)

Question 14

SEVERE FORE OF HFRS

Answer 14

a lot of eye issue, hurt to move the eyes
photophobia and can develop blurry vision

Petechiae develop on the 3rd to 5th day, initially on the palate, then at pressure areas such as the axillary folds.

costovertebral tenderness= retripetiotoneal edema

Question 15

name of severe form of HFRS

Answer 15

korean H fever or that seen in the balkans

Question 16

hanta virus pulmonary syndrome example

Answer 16

sin nombre virus which infects the deer mouse

Question 17

what’s unique of pulmonary syndrome

Answer 17

he conjunctival and cutaneous signs of vascular involvement seen in other types of HF are absent!!
izziness is common and vertigo occasional

Question 18

symptoms of pulmonary

Answer 18

non cariogenic pulmonary edema
hypotension - which is why in treatment you don’t want to give too much aggressive fluids as you have bradicardia

Question 19

West Nile virus is part of

Answer 19

same family as dengue + yellow spread by mosquitoes from birds

Question 20

which is called break bone fever

Answer 20

because of the painful backache, muscle and joint pain, and severe headache. Painful fever!

Question 21

IP YELLOW FEVER

Answer 21

3-6 days

Question 22

who critreria for dengue

Answer 22

FEVeR
HEMORRHAGIC MANIFESTATIONS
HEPATOMEGALY
THROMBOCYTOPENIA
HCT - increased by 20 %

Question 23

KEY buzzord for dengue

Answer 23

1. retrorbotal pain

Question 24

IP dengue

Answer 24

4-10 days

Question 25

sevre dengue

Answer 25

severe abdo pain
perisstant vomitting - at least 3 x in 24 h
bleeding - gums, nose , stool, urine