Pathophys acid base water Flashcards

1
Q

Where is the majority of body fluid stored?

A

Intracellular (2/3)

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2
Q

The majority of extracellular fluid is stored where?

A

Interstitial fluid (2/3)

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3
Q

What electrolytes are stored primarily intracellular?

A

K+, Mg2+, PO4 3-

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4
Q

What electrolytes are stored primarily extracellular?

A

Na+, Ca2+, Cl-, HCO3-

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5
Q

What hormones stimulate decreased urine output? (3)

A

Angiotensin II
ADH
Aldosterone

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6
Q

What hormones stimulate increased urine output?

A

Atrial natriuretic peptide

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7
Q

Long term inhibition of thirst is mostly associated with?
A) Cooling of the mouth
B) Distention of the stomach by ingested water
C) A drop in blood osmolarity
D) Moistening of the mouth
E) Increased salivation

A

C

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8
Q

In hypovolemia you see _____ osmolarity, whereas in dehydration you see _____ osmolarity

A

Constant

Increased

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9
Q

In hypervolemia, the extracellular fluid is _____ (iso/hyper/hypo tonic)

A

Isotonic

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10
Q

In hypotonic hydration, the extracellular fluid is ______.(iso/hyper/hypo tonic)

A

hypotonic

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11
Q

In what compartment does fluid accumulate in edema?

A

Interstitial fluid (tissue fluid)

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12
Q
Which of the following holds the largest concentration of Ca2+ ions?
A) interstitial fluid
B) intracellular
C) Sarcoplasmic reticulum
D) The stomach
A

C

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13
Q

Affect of aldosterone on Na+? Water?

A

Retains Na+ and water.

Maintains Na+ blood plasma concentration

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14
Q

Affect of ADH on Na+? Water?

A

Retains water, decreasing blood plasma Na+ concentration

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15
Q

Affect of ANP on Na+? Water?

A

Increases excretion of Na+ and water.

Decreases blood plasma concentration.

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16
Q

What hormones regulate K+ blood plasma levels?

A

Aldosterone

17
Q

Affect of aldosterone on K+?

A

Excretion of K+ by kidneys

Decreases K+ blood plasma concentration

18
Q

What is the counter ion of Na+?

A

Cl-

19
Q

Functions of Cl-?

A

Stomach denaturation, Fe solubility, Cl- shift, influences pH regulation

20
Q

Functions of Calcium?

A

Skeletal strength, muscle contraction, NT release, blood clotting, poly sperm blockage

21
Q

What hormones regulate calcium?

A

PTH, calcitriol, calcitonin

22
Q

Functions of phosphates?

A

Buffer, activates metabolic pathways, building blocks of nucleotides

23
Q

What is the 2nd most abundant cation in ICF?

A

Magnesium

24
Q

What is the greatest determinant of intracellular volume?

A

Extracellular Na+

25
Q

Normal blood pH?

A

7.35-7.45

26
Q

Acid is added to the blood from where?

A

The GI tract and cell metabolic waste

27
Q

What type of acids are produced by cells as metabolic waste products?

A

Lactic acid, phosphoric acid, ketoacids

28
Q

What type of cells in the kidney turn on in acidic states?

A

Type A intercalated cells

29
Q

How does the body maintain normal pH when acid is added to the blood?

A

H+ is secreted in the urine. HCO3- is reabsorbed into the blood.

30
Q

Where do alkaline products in the blood come from?

A

Absorbed from GI tract

31
Q

How does the body maintain normal pH when bases are added to the blood?

A

Excrete HCO3- into urine

Reabsorbed into the blood

32
Q

What type of kidney cells function in basic environments?

A

Type B intercalated cells

33
Q

How does the body compensate for acidosis?

A

Increase respiratory rate to breath off CO2

34
Q

How does the body compensate for alkalosis?

A

Decrease respiratory rate

35
Q

The most efficient buffer system in the body is the _____.

The fastest buffer system is _____.

A

Kidneys

Lungs

36
Q

What are the 3 major chemical buffers?

Do they work intracellular or extracellular?

A

Carbonic acid and bicarbonate - ECF
Phosphate - ICF
Protein - ICF